K-Cl cotransporter KCC2--a moonlighting protein in excitatory and inhibitory synapse development and function (Q38218526)

31 August 2017

title

K-Cl cotransporter KCC2--a moonlighting protein in excitatory and inhibitory synapse development and function (English)

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31 August 2017

Peter Blaesse

1

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31 August 2017

Tobias Schmidt

series ordinal

2

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31 August 2017

publication date

10 June 2014

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31 August 2017

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31 August 2017

volume

467

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31 August 2017

issue

4

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31 August 2017

page(s)

615-624

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Ammonium action on post-synaptic inhibition in crayfish neurones: implications for the mechanism of chloride extrusion.

31 August 2017

cites work

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Tonic activation of group I mGluRs modulates inhibitory synaptic strength by regulating KCC2 activity.

21 January 2018

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Targeting calpain in synaptic plasticity

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Genetic Control of Biochemical Reactions in Neurospora

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Two types of chloride transporters are required for GABA(A) receptor-mediated inhibition in C. elegans

21 January 2018

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Excitatory actions of gaba during development: the nature of the nurture

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The GABA excitatory/inhibitory shift in brain maturation and neurological disorders

21 January 2018

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Cation-chloride cotransporters and neuronal function

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Oligomerization of KCC2 correlates with development of inhibitory neurotransmission.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Activation of 5-HT2A receptors upregulates the function of the neuronal K-Cl cotransporter KCC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Upregulation of KCC2 activity by zinc-mediated neurotransmission via the mZnR/GPR39 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Early expression of KCC2 in rat hippocampal cultures augments expression of functional GABA synapses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Moonlighting is mainstream: paradigm adjustment required

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Altered chloride homeostasis in neurological disorders: a new target

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Disrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited states

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Human and murine phenotypes associated with defects in cation-chloride cotransport

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

The "Miracle" fetus: an excellent model for apoptotic cell-induced immune tolerance?

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Glycinergic tonic inhibition of hippocampal neurons with depolarizing GABAergic transmission elicits histopathological signs of temporal lobe epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

An ion transport-independent role for the cation-chloride cotransporter KCC2 in dendritic spinogenesis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Role of activity-dependent regulation of neuronal chloride homeostasis in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Physiology of SLC12 transporters: lessons from inherited human genetic mutations and genetically engineered mouse knockouts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Chloride extrusion enhancers as novel therapeutics for neurological diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Genomics of alternative splicing: evolution, development and pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

The KCl cotransporter, KCC2, is highly expressed in the vicinity of excitatory synapses in the rat hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Evolution of the cation chloride cotransporter family: ancient origins, gene losses, and subfunctionalization through duplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Mutations in the K+/Cl- cotransporter gene kazachoc (kcc) increase seizure susceptibility in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Intracellular zinc inhibits KCC2 transporter activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Premature expression of KCC2 in embryonic mice perturbs neural development by an ion transport-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

21 January 2018

Moonlighting proteins.

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Moonlighting proteins: old proteins learning new tricks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Moonlighting proteins--an update.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Non-conducting functions of voltage-gated ion channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Modulation of neuronal activity by phosphorylation of the K-Cl cotransporter KCC2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Roles of the cation-chloride cotransporters in neurological disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

GABA actions and ionic plasticity in epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor-mediated currents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

KCC2 interacts with the dendritic cytoskeleton to promote spine development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Distribution of neuronal KCC2a and KCC2b isoforms in mouse CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

The role of chloride transport in postsynaptic inhibition of hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Disrupted dentate granule cell chloride regulation enhances synaptic excitability during development of temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Molecular characterization of a putative K-Cl cotransporter in rat brain. A neuronal-specific isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Knocking down of the KCC2 in rat hippocampal neurons increases intracellular chloride concentration and compromises neuronal survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Chloride regulation in the pain pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Short-term ionic plasticity at GABAergic synapses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Protein adaptation: mitotic functions for membrane trafficking proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

SNARE-dependent upregulation of potassium chloride co-transporter 2 activity after metabotropic zinc receptor activation in rat cortical neurons in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Raising cytosolic Cl- in cerebellar granule cells affects their excitability and vestibulo-ocular learning

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Single-gene disorders: what role could moonlighting enzymes play?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

The potassium chloride cotransporter KCC-2 coordinates development of inhibitory neurotransmission and synapse structure in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Regulation of GABAergic synapse formation and plasticity by GSK3beta-dependent phosphorylation of gephyrin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Coexpression and heteromerization of two neuronal K-Cl cotransporter isoforms in neonatal brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Clustering of neuronal K+-Cl- cotransporters in lipid rafts by tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

The potassium-chloride cotransporter 2 promotes cervical cancer cell migration and invasion by an ion transport-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Hyperexcitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Coincident pre- and postsynaptic activity modifies GABAergic synapses by postsynaptic changes in Cl- transporter activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Electrical compartmentalization in dendritic spines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

RVG-mediated calpain2 gene silencing in the brain impairs learning and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Brain-derived neurotrophic factor and epidermal growth factor activate neuronal m-calpain via mitogen-activated protein kinase-dependent phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

17-Beta-estradiol increases neuronal excitability through MAP kinase-induced calpain activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

N-methyl-D-aspartate receptor- and calpain-mediated proteolytic cleavage of K+-Cl- cotransporter-2 impairs spinal chloride homeostasis in neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Cortical neurons lacking KCC2 expression show impaired regulation of intracellular chloride

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1547-6

Expression and function of chloride transporters during development of inhibitory neurotransmission in the auditory brainstem.

21 January 2018

1 reference

12 December 2020

The one gene-one enzyme hypothesis

1 reference

12 December 2020

Outward chloride/cation co-transport in mammalian cortical neurons

1 reference

12 December 2020

A variant of KCC2 from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation

1 reference

12 December 2020

Spike-timing dependent plasticity in inhibitory circuits

1 reference

12 December 2020

Calpain and the glutamatergic synapse

1 reference

12 December 2020

Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever!

1 reference

12 December 2020

Current view on the functional regulation of the neuronal K(+)-Cl(-) cotransporter KCC2

1 reference

12 December 2020

10.1007/S00424-014-1547-6

Identifiers

DOI

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Dimensions Publication ID

31 August 2017

1019285869

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