Protein transport into the human ER and related diseases, Sec61-channelopathies (Q38220635)

31 August 2017

title

Protein transport into the human ER and related diseases, Sec61-channelopathies (English)

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31 August 2017

Sarah Haßdenteufel

1

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31 August 2017

Marie-Christine Klein

series ordinal

2

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31 August 2017

Armin Melnyk

series ordinal

3

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31 August 2017

Richard Zimmermann

series ordinal

4

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31 August 2017

language of work or name

1 reference

27 May 2014

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Biochemistry and Cell Biology

31 August 2017

published in

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31 August 2017

volume

92

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31 August 2017

issue

6

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31 August 2017

page(s)

499-509

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The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum

31 August 2017

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Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complex

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BiP modulates the affinity of its co-chaperone ERj1 for ribosomes

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The endoplasmic reticulum: a multifunctional signaling organelle

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ERj1p uses a universal ribosomal adaptor site to coordinate the 80S ribosome at the membrane.

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Disulfide bond formation in the mammalian endoplasmic reticulum

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70K heat shock related proteins stimulate protein translocation into microsomes

21 January 2018

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21 January 2018

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Mutations in SEC63 cause autosomal dominant polycystic liver disease

21 January 2018

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A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

21 January 2018

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Polycystic liver disease is a disorder of cotranslational protein processing.

21 January 2018

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A novel type of co-chaperone mediates transmembrane recruitment of DnaK-like chaperones to ribosomes

21 January 2018

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Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes

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Endoplasmic reticulum structure and interconnections with other organelles

21 January 2018

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Interaction of calmodulin with Sec61α limits Ca2+ leakage from the endoplasmic reticulum

21 January 2018

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Molecular staging for survival prediction of colorectal cancer patients

21 January 2018

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Purification of microsomal signal peptidase as a complex

21 January 2018

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A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation

21 January 2018

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https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Passive calcium leak via translocon is a first step for iPLA2-pathway regulated store operated channels activation

21 January 2018

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https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Substrate-specific function of the translocon-associated protein complex during translocation across the ER membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Endoplasmic reticulum stress sensing in the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion

21 January 2018

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https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane

21 January 2018

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https://api.crossref.org/works/10.1139%2FBCB-2014-0043

A protein of the endoplasmic reticulum involved early in polypeptide translocation

21 January 2018

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https://api.crossref.org/works/10.1139%2FBCB-2014-0043

A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation

21 January 2018

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https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Regulation of the Protein-Conducting Channel by a Bound Ribosome

21 January 2018

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https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Immunoglobulin heavy chain binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

A new role for BiP: closing the aqueous translocon pore during protein integration into the ER membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Structure of the signal recognition particle interacting with the elongation-arrested ribosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Following the signal sequence from ribosomal tunnel exit to signal recognition particle

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Evolutionary conservation of components of the protein translocation complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Ca2+-calmodulin inhibits tail-anchored protein insertion into the mammalian endoplasmic reticulum membrane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

MAM: more than just a housekeeper

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

TRAM regulates the exposure of nascent secretory proteins to the cytosol during translocation into the endoplasmic reticulum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Structure of the SecY complex unlocked by a preprotein mimic.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

TRC40 can deliver short secretory proteins to the Sec61 translocon

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

The signal sequence influences post-translational ER translocation at distinct stages

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Genomic and expression analysis of the 3q25-q26 amplification unit reveals TLOC1/SEC62 as a probable target gene in prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

An ER-mitochondria tethering complex revealed by a synthetic biology screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Live cell calcium imaging combined with siRNA mediated gene silencing identifies Ca²⁺ leak channels in the ER membrane and their regulatory mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Sec62 bridges the gap from 3q amplification to molecular cell biology in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

X-ray structure of a bacterial oligosaccharyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

A point mutation in Sec61alpha1 leads to diabetes and hepatosteatosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Basal and physiological Ca(2+) leak from the endoplasmic reticulum of pancreatic acinar cells. Second messenger-activated channels and translocons

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

A new congenital disorder of glycosylation caused by a mutation in SSR4, the signal sequence receptor 4 protein of the TRAP complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Glioblastoma proto-oncogene SEC61gamma is required for tumor cell survival and response to endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

The unfolding tale of the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Intricate links between ER stress and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

The protein-conducting channel in the membrane of the endoplasmic reticulum is open laterally toward the lipid bilayer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Mammalian Sec61 is associated with Sec62 and Sec63

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Different transmembrane domains associate with distinct endoplasmic reticulum components during membrane integration of a polytopic protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Single Copies of Sec61 and TRAP Associate with a Nontranslating Mammalian Ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

A membrane component essential for vectorial translocation of nascent proteins across the endoplasmic reticulum: requirements for its extraction and reassociation with the membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Identification and characterization of a membrane component essential for the translocation of nascent proteins across the membrane of the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Oligosaccharyltransferase: the central enzyme of N-linked protein glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Evolutionary gain of function for the ER membrane protein Sec62 from yeast to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Lumenal proteins of the mammalian endoplasmic reticulum are required to complete protein translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

The mystery of nonclassical protein secretion. A current view on cargo proteins and potential export routes

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Mechanisms of regulated unconventional protein secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

The mammalian endoplasmic reticulum-associated degradation system

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Intracellular Ca(2+) release via the ER translocon activates store-operated calcium entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Crystal structure of a bacterial signal peptidase in complex with a beta-lactam inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Intracellular Aspects of the Process of Protein Synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Preserving the membrane barrier for small molecules during bacterial protein translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Structure of the SecY channel during initiation of protein translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

The retention signal for soluble proteins of the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Alpha-1-antitrypsin deficiency: importance of proteasomal and autophagic degradative pathways in disposal of liver disease-associated protein aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Structure and 3D arrangement of endoplasmic reticulum membrane-associated ribosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Structure of the mammalian oligosaccharyl-transferase complex in the native ER protein translocon

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Endoplasmic reticulum-bound ribosomes reside in stable association with the translocon following termination of protein synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Ribosome exchange revisited: a mechanism for translation-coupled ribosome detachment from the ER membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Biogenesis of tail-anchored proteins: the beginning for the end?

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Protein-folding homeostasis in the endoplasmic reticulum and nutritional regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Myopathy in Marinesco-Sjögren syndrome links endoplasmic reticulum chaperone dysfunction to nuclear envelope pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

The role of p58IPK in protecting the stressed endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

The involvement of calcium in transport of secretory proteins from the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Sec61p is part of the endoplasmic reticulum-associated degradation machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Merging cultures in the study of membrane traffic

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Peroxisomes: another branch of the secretory pathway?

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Control of glycosylation of MHC class II-associated invariant chain by translocon-associated RAMP4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

The mammalian unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Mutations in SIL1 cause Marinesco-Sjögren syndrome, a cerebellar ataxia with cataract and myopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

A calmodulin-dependent translocation pathway for small secretory proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

A protein-conducting channel in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Large aqueous channels in membrane vesicles derived from the rough endoplasmic reticulum of canine pancreas or the plasma membrane of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Road to ruin: targeting proteins for degradation in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

The endoplasmic reticulum-associated degradation pathways of budding yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Homologs of the yeast Sec complex subunits Sec62p and Sec63p are abundant proteins in dog pancreas microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Polypeptide‐binding proteins mediate completion of co‐translational protein translocation into the mammalian endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Ribosome-translocon complex mediates calcium leakage from endoplasmic reticulum stores

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

X-ray structure of a protein-conducting channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Signal sequence-dependent function of the TRAM protein during early phases of protein transport across the endoplasmic reticulum membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Patterns of amino acids near signal-sequence cleavage sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Translocation of proteins across the endoplasmic reticulum. II. Signal recognition protein (SRP) mediates the selective binding to microsomal membranes of in-vitro-assembled polysomes synthesizing secretory protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

A protein complex required for signal-sequence-specific sorting and translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

The Sec61p complex is a dynamic precursor activated channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Analysis of the membrane proteome of canine pancreatic rough microsomes identifies a novel Hsp40, termed ERj7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Protein accumulation and neurodegeneration in the woozy mutant mouse is caused by disruption of SIL1, a cochaperone of BiP

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Alteration of the unfolded protein response modifies neurodegeneration in a mouse model of Marinesco-Sjögren syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

TRAP assists membrane protein topogenesis at the mammalian ER membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Oligomeric Rings of the Sec61p Complex Induced by Ligands Required for Protein Translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Lanthanum ions inhibit the mammalian Sec61 complex in its channel dynamics and protein transport activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

Structural determinants of lateral gate opening in the protein translocon

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

A Network of Cytosolic Factors Targets SRP-Independent Proteins to the Endoplasmic Reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FBCB-2014-0043

21 January 2018

Identifiers

DOI

10.1139/BCB-2014-0043

1 reference

31 August 2017

1 reference