Hyaluronan-CD44 interaction promotes oncogenic signaling, microRNA functions, chemoresistance, and radiation resistance in cancer stem cells leading to tumor progression. (Q38235802)

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scientific article published on January 2014

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English	Hyaluronan-CD44 interaction promotes oncogenic signaling, microRNA functions, chemoresistance, and radiation resistance in cancer stem cells leading to tumor progression.	scientific article published on January 2014

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scholarly article

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11 March 2020

Hyaluronan-CD44 interaction promotes oncogenic signaling, microRNA functions, chemoresistance, and radiation resistance in cancer stem cells leading to tumor progression (English)

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11 March 2020

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neoplastic stem cells

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tumor progression

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author name string

Lilly Y W Bourguignon

1

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Marisa Shiina

2

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Jian-Jian Li

3

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publication date

1 January 2014

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11 March 2020

Advances in Cancer Research

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123

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255-275

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11 March 2020

A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian hyaluronan synthases: investigation of functional relationships in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

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Rho GTPases are over-expressed in human tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

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Rho-kinase (ROK) promotes CD44v(3,8-10)-ankyrin interaction and tumor cell migration in metastatic breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

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CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

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Prognostic value of c-erbB2 and other markers in patients treated with chemotherapy for recurrent head and neck cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

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Hyaluronan: a multifunctional, megaDalton, stealth molecule

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

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CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

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Cisplatin and radiation sensitivity in human head and neck squamous carcinomas are independently modulated by glutathione and transcription factor NF-kappaB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel CD44 v3 isoform is involved in head and neck squamous cell carcinoma progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyaluronan in morphogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD44-mediated oncogenic signaling and cytoskeleton activation during mammary tumor progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling properties of hyaluronan receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyaluronan promotes signaling interaction between CD44 and the transforming growth factor beta receptor I in metastatic breast tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyaluronan and tumor growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prospective identification of tumorigenic breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RhoGTPases and Their Role in Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Multidrug Resistance in Cancer Cells by Hyaluronan

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ABC Transporters: From Microorganisms to Man

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD44: The hyaluronan receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule-targeted anticancer agents and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of ErbB2 enhances radiation-induced NF-kappaB activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sox genes and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MDR1, chemotherapy and chromatin remodeling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Core transcriptional regulatory circuitry in human embryonic stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of CD 44 s, CD 44 v 3 and CD 44 v 6 in benign and malignant breast lesions: correlation and colocalization with hyaluronan

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyaluronan and the interaction between CD44 and epidermal growth factor receptor in oncogenic signaling and chemotherapy resistance in head and neck cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cDNA sequence for human erythrocyte ankyrin

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyaluronan-CD44 interaction with neural Wiskott-Aldrich syndrome protein (N-WASP) promotes actin polymerization and ErbB2 activation leading to beta-catenin nuclear translocation, transcriptional up-regulation, and cell migration in ovarian tumor ce

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of CD44 V3-containing isoforms with tumor cell growth, migration, matrix metalloproteinase expression, and lymph node metastasis in head and neck cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of hyaluronan-CD44 interaction on topoisomerase II activity and etoposide cytotoxicity in head and neck cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of hyaluronic acid in hemopoietic stem cell biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inhibitors of apoptosis (IAPs) as cancer targets

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD44s and CD44v6 expression in head and neck epithelia

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF-kappaB-mediated HER2 overexpression in radiation-adaptive resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD44 variant isoforms in head and neck squamous cell carcinoma progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemothera

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oct4 regulates the miR-302 cluster in P19 mouse embryonic carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyaluronan and mesenchymal stem cells: from germ layer to cartilage and bone

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of hyaluronan-mediated CD44 signaling in head and neck squamous cell carcinoma progression and chemoresistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyaluronan-CD44v3 interaction with Oct4-Sox2-Nanog promotes miR-302 expression leading to self-renewal, clonal formation, and cisplatin resistance in cancer stem cells from head and neck squamous cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HER2-associated radioresistance of breast cancer stem cells isolated from HER2-negative breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug resistance in clinical practice: patterns of treatment failure in advanced breast and ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ankyrin-binding domain of CD44(GP85) is required for the expression of hyaluronic acid-mediated adhesion function

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New CD44 splice variants associated with human breast cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression cloning and molecular characterization of HAS protein, a eukaryotic hyaluronan synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MT-MMP expression and localisation in human lung and breast cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteases associated with invadopodia, and their role in degradation of extracellular matrix.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coexpression of CD44 variant (v10/ex14) and CD44S in human mammary epithelial cells promotes tumorigenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyaluronan synthases

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho GTPases and the actin cytoskeleton

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The gene structure and promoter sequence of mouse hyaluronan synthase 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ankyrin-binding domain of CD44s is involved in regulating hyaluronic acid-mediated functions and prostate tumor cell transformation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD44v(3,8-10) is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD44 isoform-cytoskeleton interaction in oncogenic signaling and tumor progression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25081533

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/B978-0-12-800092-2.00010-1

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11 March 2020

1 reference

Europe PubMed Central

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11 March 2020

1 reference

Europe PubMed Central

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11 March 2020

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