mRNA-based therapeutics--developing a new class of drugs (Q38252360)

1 September 2017

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title

mRNA-based therapeutics--developing a new class of drugs (English)

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1 September 2017

Ugur Sahin

1

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Özlem Türeci

series ordinal

3

object named as

Özlem Türeci

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1 September 2017

2

Katalin Karikó

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1 September 2017

19 September 2014

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Nature Reviews Drug Discovery

1 September 2017

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1 September 2017

13

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1 September 2017

759-780

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1 September 2017

10

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https://scigraph.springernature.com/pub.10.1038/nrd4278

1 September 2017

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Systemic delivery of modified mRNA encoding herpes simplex virus 1 thymidine kinase for targeted cancer gene therapy

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Successful use of mRNA-nucleofection for overexpression of interleukin-10 in murine monocytes/macrophages for anti-inflammatory therapy in a murine model of autoimmune myocarditis

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Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Synthetic messenger RNA as a tool for gene therapy

31 March 2020

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Phosphorothioate cap analogs stabilize mRNA and increase translational efficiency in mammalian cells

31 March 2020

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Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS

31 March 2020

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Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Lsm proteins bind and stabilize RNAs containing 5' poly(A) tracts

31 March 2020

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mRNA as a versatile tool for exogenous protein expression

31 March 2020

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AU-rich elements: characterization and importance in mRNA degradation

31 March 2020

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Codon bias and heterologous protein expression

31 March 2020

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A role for codon order in translation dynamics.

31 March 2020

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The influence of codon context on genetic code translation

31 March 2020

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Engineering genes for predictable protein expression

31 March 2020

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Efficient stimulation of HIV-1-specific T cells using dendritic cells electroporated with mRNA encoding autologous HIV-1 Gag and Env proteins.

31 March 2020

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A "silent" polymorphism in the MDR1 gene changes substrate specificity

31 March 2020

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Presentation of out-of-frame peptide/MHC class I complexes by a novel translation initiation mechanism

31 March 2020

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+1 Frameshifting as a novel mechanism to generate a cryptic cytotoxic T lymphocyte epitope derived from human interleukin 10.

31 March 2020

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Constitutive display of cryptic translation products by MHC class I molecules

31 March 2020

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Detection of prokaryotic mRNA signifies microbial viability and promotes immunity

31 March 2020

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HIV gag mRNA transfection of dendritic cells (DC) delivers encoded antigen to MHC class I and II molecules, causes DC maturation, and induces a potent human in vitro primary immune response.

31 March 2020

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Messenger RNA-based vaccines with dual activity induce balanced TLR-7 dependent adaptive immune responses and provide antitumor activity.

31 March 2020

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Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA.

31 March 2020

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Particle size and activation threshold: a new dimension of danger signaling.

31 March 2020

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Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

31 March 2020

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Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

31 March 2020

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Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

31 March 2020

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Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides

31 March 2020

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The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

31 March 2020

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Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity

31 March 2020

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Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus

31 March 2020

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Activation of MDA5 requires higher-order RNA structures generated during virus infection

31 March 2020

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Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.

31 March 2020

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Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection

31 March 2020

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Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA

31 March 2020

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5'-Triphosphate RNA is the ligand for RIG-I

31 March 2020

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Nucleoside modifications modulate activation of the protein kinase PKR in an RNA structure-specific manner

31 March 2020

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Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation

31 March 2020

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Protein expression from exogenous mRNA: uptake by receptor-mediated endocytosis and trafficking via the lysosomal pathway.

31 March 2020

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Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

31 March 2020

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Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation

31 March 2020

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Gene transfer into mouse lyoma cells by electroporation in high electric fields

31 March 2020

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31 March 2020

12 December 2020

Nonviral transfection of distinct types of human dendritic cells: high-efficiency gene transfer by electroporation into hematopoietic progenitor- but not monocyte-derived dendritic cells

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Phase I/II trial of melanoma therapy with dendritic cells transfected with autologous tumor-mRNA.

31 March 2020

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Clinical-grade manufacturing of autologous mature mRNA-electroporated dendritic cells and safety testing in acute myeloid leukemia patients in a phase I dose-escalation clinical trial

31 March 2020

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Induction of complete and molecular remissions in acute myeloid leukemia by Wilms' tumor 1 antigen-targeted dendritic cell vaccination

31 March 2020

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Therapeutic vaccination with an autologous mRNA electroporated dendritic cell vaccine in patients with advanced melanoma.

31 March 2020

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Intravenous and intradermal TriMix-dendritic cell therapy results in a broad T-cell response and durable tumor response in a chemorefractory stage IV-M1c melanoma patient

31 March 2020

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Dendritic cells loaded with mRNA encoding full-length tumor antigens prime CD4+ and CD8+ T cells in melanoma patients

31 March 2020

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Transfection of cells using flow-through electroporation based on constant voltage.

31 March 2020

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Results of the first phase I/II clinical vaccination trial with direct injection of mRNA.

31 March 2020

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Design of multifunctional non-viral gene vectors to overcome physiological barriers: dilemmas and strategies

31 March 2020

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Rational design of cationic lipids for siRNA delivery

31 March 2020

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Safety and efficacy of RNAi therapy for transthyretin amyloidosis

31 March 2020

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Induction of anti-tumor immunity with epidermal cells pulsed with tumor-derived RNA or intradermal administration of RNA

31 March 2020

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Intranodal vaccination with naked antigen-encoding RNA elicits potent prophylactic and therapeutic antitumoral immunity.

31 March 2020

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FLT3 ligand enhances the cancer therapeutic potency of naked RNA vaccines.

31 March 2020

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Preclinical Evaluation of TriMix and Antigen mRNA-Based Antitumor Therapy

31 March 2020

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Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection

31 March 2020

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Nonviral delivery of self-amplifying RNA vaccines

31 March 2020

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In vivo messenger RNA introduction into the central nervous system using polyplex nanomicelle

31 March 2020

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Targeted delivery of nanoparticles for the treatment of lung diseases.

31 March 2020

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Tumor delivery of macromolecular drugs based on the EPR effect

31 March 2020

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A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

31 March 2020

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Human neoplasms elicit multiple specific immune responses in the autologous host

31 March 2020

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Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells.

31 March 2020

1 reference

Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA.

31 March 2020

1 reference

mRNA: From a chemical blueprint for protein production to an off-the-shelf therapeutic.

31 March 2020

1 reference

Tumor vaccination using messenger RNA: prospects of a future therapy

31 March 2020

1 reference

Induction of human dendritic cell maturation using transfection with RNA encoding a dominant positive toll-like receptor 4.

31 March 2020

1 reference

Enhancing the T-cell Stimulatory Capacity of Human Dendritic Cells by Co-electroporation With CD40L, CD70 and Constitutively Active TLR4 Encoding mRNA

31 March 2020

1 reference

Cytokine maturation followed by CD40L mRNA electroporation results in a clinically relevant dendritic cell product capable of inducing a potent proinflammatory CTL response.

31 March 2020

1 reference

Immunologic activity and safety of autologous HIV RNA-electroporated dendritic cells in HIV-1 infected patients receiving antiretroviral therapy

31 March 2020

1 reference

Dendritic cells transfected with interleukin-12 and tumor-associated antigen messenger RNA induce high avidity cytotoxic T cells.

31 March 2020

1 reference

Vaccination with mRNA-Electroporated Dendritic Cells Induces Robust Tumor Antigen-Specific CD4+ and CD8+ T Cells Responses in Stage III and IV Melanoma Patients

31 March 2020

1 reference

Vaccination with messenger RNA (mRNA).

31 March 2020

1 reference

Polarization of immunity induced by direct injection of naked sequence-stabilized mRNA vaccines

31 March 2020

1 reference

Toll-like receptor-dependent activation of several human blood cell types by protamine-condensed mRNA.

31 March 2020

1 reference

Highly potent mRNA based cancer vaccines represent an attractive platform for combination therapies supporting an improved therapeutic effect

31 March 2020

1 reference

Simultaneous ex vivo quantification of antigen-specific CD4+ and CD8+ T cell responses using in vitro transcribed RNA

31 March 2020

1 reference

Increased Antigen Presentation Efficiency by Coupling Antigens to MHC Class I Trafficking Signals

31 March 2020

1 reference

Antitumor vaccination with synthetic mRNA: strategies for in vitro and in vivo preclinical studies.

31 March 2020

1 reference

mTOR inhibition improves antitumor effects of vaccination with antigen-encoding RNA.

31 March 2020

1 reference

Exploiting the mutanome for tumor vaccination.

31 March 2020

1 reference

Targeting the tumor mutanome for personalized vaccination therapy

31 March 2020

1 reference

The regulatory landscape for actively personalized cancer immunotherapies

31 March 2020

1 reference

Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor

31 March 2020

1 reference

Transiently redirected T cells for adoptive transfer.

31 March 2020

1 reference

Treatment of advanced leukemia in mice with mRNA engineered T cells

31 March 2020

1 reference

Regimen-specific effects of RNA-modified chimeric antigen receptor T cells in mice with advanced leukemia

31 March 2020

1 reference

Rapidly produced SAM(®) vaccine against H7N9 influenza is immunogenic in mice.

31 March 2020

1 reference

A phase I/IIa immunotherapy trial of HIV-1-infected patients with Tat, Rev and Nef expressing dendritic cells followed by treatment interruption

31 March 2020

1 reference

mRNA-based dendritic cell vaccination induces potent antiviral T-cell responses in HIV-1-infected patients.

31 March 2020

1 reference

A new generation of animal cell expression vectors based on the Semliki Forest virus replicon

31 March 2020

1 reference

Self-replicating Semliki Forest virus RNA as recombinant vaccine

31 March 2020

1 reference

31 March 2020

1 reference

RNA: the new revolution in nucleic acid vaccines

31 March 2020

1 reference

Self-replicative RNA vaccines elicit protection against influenza A virus, respiratory syncytial virus, and a tickborne encephalitis virus

31 March 2020

1 reference

Kunjin virus replicon vaccine vectors induce protective CD8+ T-cell immunity

31 March 2020

1 reference

A chimeric alphavirus RNA replicon gene-based vaccine for human parainfluenza virus type 3 induces protective immunity against intranasal virus challenge

31 March 2020

1 reference

From allergen genes to allergy vaccines

31 March 2020

1 reference

Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization

31 March 2020

1 reference

DNA vaccines for the prevention and treatment of allergy

31 March 2020

1 reference

The latex allergen Hev b 5 transcript is widely distributed after subcutaneous injection in BALB/c mice of its DNA vaccine

31 March 2020

1 reference

Immunize and disappear-safety-optimized mRNA vaccination with a panel of 29 allergens.

31 March 2020

1 reference

Prophylactic mRNA vaccination against allergy

31 March 2020

1 reference

Comprehensive glyco-proteomic analysis of human alpha1-antitrypsin and its charge isoforms

31 March 2020

1 reference

Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides

31 March 2020

1 reference

Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins

31 March 2020

1 reference

Precursor convertases: an evolutionary ancient, cell-specific, combinatorial mechanism yielding diverse bioactive peptides and proteins.

31 March 2020

1 reference

Human secretory signal peptide description by hidden Markov model and generation of a strong artificial signal peptide for secreted protein expression

31 March 2020

1 reference

Gene electro-transfer of an improved erythropoietin plasmid in mice and non-human primates

31 March 2020

1 reference

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

31 March 2020

1 reference

Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.

31 March 2020

1 reference

Feeder-free derivation of human induced pluripotent stem cells with messenger RNA

31 March 2020

1 reference

RNA-based tools for nuclear reprogramming and lineage-conversion: towards clinical applications.

31 March 2020

1 reference

Human iPSC-based modeling of late-onset disease via progerin-induced aging

31 March 2020

1 reference

Human induced pluripotent stem cells and their use in drug discovery for toxicity testing

31 March 2020

1 reference

Steps toward safe cell therapy using induced pluripotent stem cells

31 March 2020

1 reference

An improved zinc-finger nuclease architecture for highly specific genome editing

31 March 2020

1 reference

Genetic engineering of human pluripotent cells using TALE nucleases

31 March 2020

1 reference

RNA-guided human genome engineering via Cas9

31 March 2020

1 reference

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

31 March 2020

1 reference

Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

31 March 2020

1 reference

Knockout rats generated by embryo microinjection of TALENs.

31 March 2020

1 reference

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

31 March 2020

1 reference

Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA.

31 March 2020

1 reference

Knockout rats via embryo microinjection of zinc-finger nucleases

31 March 2020

1 reference

Generation of gene-modified mice via Cas9/RNA-mediated gene targeting

31 March 2020

1 reference

Effective gene targeting in rabbits using RNA-guided Cas9 nucleases.

31 March 2020

1 reference

Generating rats with conditional alleles using CRISPR/Cas9.

31 March 2020

1 reference

Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos.

31 March 2020

1 reference

Mammalian germ-line transgenesis by transposition.

31 March 2020

1 reference

RNA as a source of transposase for Sleeping Beauty-mediated gene insertion and expression in somatic cells and tissues

31 March 2020

1 reference

A simple and highly efficient transgenesis method in mice with the Tol2 transposon system and cytoplasmic microinjection

31 March 2020

1 reference

Transposon-mediated BAC transgenesis in zebrafish and mice

31 March 2020

1 reference

Insertional mutagenesis by a hybrid piggyBac and sleeping beauty transposon in the rat.

31 March 2020

1 reference

Exogenous mRNA delivery and bioavailability in gene transfer mediated by piggyBac transposition

31 March 2020

1 reference

Foreign nucleic acids as the stimulus to make interferon

31 March 2020

1 reference

Inducers of interferon and host resistance. 3. Double-stranded RNA from reovirus type 3 virions (reo 3-RNA).

31 March 2020

1 reference

Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L

31 March 2020

1 reference

Type I IFN counteracts the induction of antigen-specific immune responses by lipid-based delivery of mRNA vaccines.

31 March 2020

1 reference

B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice

31 March 2020

1 reference

Autoimmune epitopes in messenger RNA.

31 March 2020

1 reference

Recommendations on risk-based strategies for detection and characterization of antibodies against biotechnology products

31 March 2020

1 reference

Pure red-cell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin

31 March 2020

1 reference

Erythropoietin gene therapy leads to autoimmune anemia in macaques

31 March 2020

1 reference

Antibodies against erythropoietin and other protein-based therapeutics: an overview

31 March 2020

1 reference

RNAi-based therapeutic strategies for metabolic disease

31 March 2020

1 reference

The liver as an immunological organ

31 March 2020

1 reference

Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B.

31 March 2020

1 reference

Defective mitochondrial DNA replication and NRTIs: pathophysiological implications in AIDS cardiomyopathy

31 March 2020

1 reference

Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs

31 March 2020

1 reference

Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts

31 March 2020

1 reference

Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs.

31 March 2020

1 reference

Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): implications for interspecies differences in mitochondrial toxicity of fialuridine

31 March 2020

1 reference

Efficient generation of human iPSCs by a synthetic self-replicative RNA.

31 March 2020

1 reference

Synthetic generation of influenza vaccine viruses for rapid response to pandemics

31 March 2020

1 reference

Friedrich Miescher and the discovery of DNA.

31 March 2020

1 reference

An unstable intermediate carrying information from genes to ribosomes for protein synthesis.

31 March 2020

2 references

31 March 2020

12 December 2020

Cloned Poliovirus Complementary DNA Is Infectious in Mammalian Cells

1 reference

Comparison of replication complexes synthesizing poliovirus RNA

31 March 2020

1 reference

Synthesis of infectious poliovirus RNA by purified T7 RNA polymerase

31 March 2020

1 reference

An alphavirus replicon particle chimera derived from venezuelan equine encephalitis and sindbis viruses is a potent gene-based vaccine delivery vector

31 March 2020

1 reference

Novel infectious particles generated by expression of the vesicular stomatitis virus glycoprotein from a self-replicating RNA.

31 March 2020

1 reference

Sindbis virus: an efficient, broad host range vector for gene expression in animal cells

31 March 2020

1 reference

Cancer therapy using a self-replicating RNA vaccine

31 March 2020

1 reference

Alphaviruses in gene therapy

31 March 2020

1 reference

RNA viruses: emerging vectors for vaccination and gene therapy

31 March 2020

1 reference

Is silence still golden? Mapping the RNAi patent landscape

31 March 2020

1 reference

Eukaryotic translation initiation is controlled by cooperativity effects within ternary complexes of 4E-BP1, eIF4E, and the mRNA 5' cap

31 March 2020

1 reference

A reevaluation of the cap-binding protein, eIF4E, as a rate-limiting factor for initiation of translation in reticulocyte lysate

31 March 2020

1 reference

Circularization of mRNA by eukaryotic translation initiation factors

31 March 2020

1 reference

The many pathways of RNA degradation

31 March 2020

1 reference

Ways and means of eukaryotic mRNA decay

31 March 2020

1 reference

Messenger RNA regulation: to translate or to degrade

31 March 2020

1 reference

Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism

31 March 2020

1 reference

Endoribonucleases--enzymes gaining spotlight in mRNA metabolism.

31 March 2020

1 reference

RNA stability: is it the endo' the world as we know it?

31 March 2020

1 reference

The highways and byways of mRNA decay

31 March 2020

1 reference

31 March 2020

1 reference

Nanoparticle-derived non-viral genetic transfection at the blood-brain barrier to enable neuronal growth factor delivery by secretion from brain endothelium.

31 March 2020

1 reference

Autocrine-paracrine effects of overexpression of hepatocyte growth factor gene on growth of endothelial cells

31 March 2020

1 reference

Generation of cytotoxic responses in mice and human individuals against hematological malignancies using survivin-RNA-transfected dendritic cells.

31 March 2020

1 reference

Induction of cytotoxic T-cell responses against the oncofetal antigen-immature laminin receptor for the treatment of hematologic malignancies.

31 March 2020

1 reference

Adoptive immunotherapy using human peripheral blood lymphocytes transferred with RNA encoding Her-2/neu-specific chimeric immune receptor in ovarian cancer xenograft model

31 March 2020

1 reference

Chimeric receptor mRNA transfection as a tool to generate antineoplastic lymphocytes

31 March 2020

1 reference

Single-step antigen loading and activation of dendritic cells by mRNA electroporation for the purpose of therapeutic vaccination in melanoma patients.

31 March 2020

1 reference

T cells expressing chimeric antigen receptors can cause anaphylaxis in humans.

31 March 2020

1 reference

Characterization of CD8+ T-cell responses in the peripheral blood and skin injection sites of melanoma patients treated with mRNA electroporated autologous dendritic cells (TriMixDC-MEL)

31 March 2020

1 reference

Intranasal vaccination with messenger RNA as a new approach in gene therapy: use against tuberculosis

31 March 2020

1 reference

Targeted genome editing across species using ZFNs and TALENs

31 March 2020

1 reference

Site specific mutation of the Zic2 locus by microinjection of TALEN mRNA in mouse CD1, C3H and C57BL/6J oocytes

31 March 2020

1 reference

Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability

31 March 2020

1 reference

Innate immune suppression enables frequent transfection with RNA encoding reprogramming proteins

31 March 2020

1 reference

Reprogramming of human fibroblasts to pluripotent stem cells using mRNA of four transcription factors.

31 March 2020

1 reference

Cochleate lipid cylinders: formation by fusion of unilamellar lipid vesicles

31 March 2020

1 reference

Translation of rabbit globin mRNA introduced by liposomes into mouse lymphocytes

31 March 2020

1 reference

5′-Terminal 7-methylguanosine in eukaryotic mRNA is required for translation

31 March 2020

1 reference

A blocked structure at the 5′ terminus of mRNA from cytoplasmic polyhedrosis virus

31 March 2020

1 reference

The synthesis of mouse hemoglobin chains in a rabbit reticulocyte cell-free system programmed with mouse reticulocyte 9S RNA

31 March 2020

1 reference

Use of frog eggs and oocytes for the study of messenger RNA and its translation in living cells

31 March 2020

1 reference

Functional messenger RNAs are produced by SP6in vitrotranscription of cloned cDNAs

31 March 2020

1 reference

Efficient genome editing in zebrafish using a CRISPR-Cas system

31 March 2020

1 reference

Half-lives of beta and gamma globin messenger RNAs and of protein synthetic capacity in cultured human reticulocytes.

31 March 2020

1 reference

12 December 2020

Engineering Factor Viii for Hemophilia Gene Therapy

1 reference

12 December 2020

Purification of mRNA guanylyltransferase and mRNA (guanine-7-) methyltransferase from vaccinia virions

1 reference

12 December 2020

Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response.

1 reference

12 December 2020

Characterization of a messenger RNA polynucleotide vaccine vector.

1 reference

12 December 2020

Production of infectious RNA transcripts from Sindbis virus cDNA clones: mapping of lethal mutations, rescue of a temperature-sensitive marker, and in vitro mutagenesis to generate defined mutants

1 reference

12 December 2020

Reprogramming human fibroblasts to pluripotency using modified mRNA.

1 reference

12 December 2020

Non-viral gene delivery methods

1 reference

12 December 2020

The RNase a superfamily: generation of diversity and innate host defense

1 reference

12 December 2020

Gene gun delivery of mRNA in situ results in efficient transgene expression and genetic immunization.

1 reference

12 December 2020

Subgenomic replicons of the flavivirus Kunjin: construction and applications

1 reference

12 December 2020

Tailing and 3'-end labeling of RNA with yeast poly(A) polymerase and various nucleotides

1 reference

12 December 2020

In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies

1 reference

12 December 2020

Optimization of the sequence of antigen loading and CD40-ligand-induced maturation of dendritic cells.

1 reference

12 December 2020

Synthesis and properties of mRNAs containing the novel "anti-reverse" cap analogs 7-methyl(3'-O-methyl)GpppG and 7-methyl (3'-deoxy)GpppG

1 reference

12 December 2020

In vitro synthesis of an infectious RNA from cDNA clones of human rhinovirus type 14.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD4278

1 reference

1 September 2017

1 reference

PubMed ID

25233993