Scorpion venom components as potential candidates for drug development (Q38272333)

1 September 2017

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title

Scorpion venom components as potential candidates for drug development (English)

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1 September 2017

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Elisabeth F. Schwartz

series ordinal

3

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1 September 2017

Ernesto Ortiz

1

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Lourival Possani Postay

series ordinal

4

object named as

Lourival D Possani

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1 September 2017

Georgina B Gurrola

2

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1 September 2017

26 November 2014

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1 September 2017

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1 September 2017

93

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1 September 2017

125-135

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Gene cloning and functional characterization of four novel antimicrobial-like peptides from scorpions of the family Vaejovidae

1 September 2017

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12 December 2020

Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog

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12 December 2020

Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis

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12 December 2020

Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa.

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12 December 2020

A new natural α-helical peptide from the venom of the scorpion Heterometrus petersii kills HCV.

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12 December 2020

Scorpion venom peptides with no disulfide bridges: a review

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12 December 2020

Invasion of human glioma cells is regulated by multiple chloride channels including ClC-3.

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12 December 2020

IsCT, a novel cytotoxic linear peptide from scorpion Opisthacanthus madagascariensis.

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12 December 2020

Expression of an antitumor-analgesic peptide from the venom of Chinese scorpion Buthus martensii karsch in Escherichia coli

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12 December 2020

Three new antimicrobial peptides from the scorpion Pandinus imperator

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12 December 2020

Therapeutic potential of chlorotoxin-like neurotoxin from the Chinese scorpion for human gliomas

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12 December 2020

Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates

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12 December 2020

Arthropod venoms and cancer

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12 December 2020

KCNMA1 gene amplification promotes tumor cell proliferation in human prostate cancer

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12 December 2020

Bengalin initiates autophagic cell death through ERK-MAPK pathway following suppression of apoptosis in human leukemic U937 cells

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12 December 2020

Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities

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12 December 2020

Invasive aspergillosis

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12 December 2020

Emerging options for the management of scorpion stings

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12 December 2020

Cloning and characterization of the cDNA sequences of two venom peptides from Chinese scorpion Buthus martensii Karsch (BmK).

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12 December 2020

Selective blockade of voltage-gated potassium channels reduces inflammatory bone resorption in experimental periodontal disease

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12 December 2020

Overview of scorpion toxins specific for Na+ channels and related peptides: biodiversity, structure-function relationships and evolution

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12 December 2020

Expression of voltage-activated chloride currents in acute slices of human gliomas

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12 December 2020

Antibacterial activity and mechanism of a scorpion venom peptide derivative in vitro and in vivo

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12 December 2020

Epidemiology of scorpionism: a global appraisal

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12 December 2020

Indian black scorpion (Heterometrus bengalensis Koch) venom induced antiproliferative and apoptogenic activity against human leukemic cell lines U937 and K562

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12 December 2020

Outside the box--novel therapeutic strategies for glioblastoma

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12 December 2020

Scorpion envenomation

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12 December 2020

Anti-proliferative effect of Kv1.3 blockers in A549 human lung adenocarcinoma in vitro and in vivo

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12 December 2020

K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom.

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12 December 2020

Scorpion venom components that affect ion-channels function

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12 December 2020

Phase I single-dose study of intracavitary-administered iodine-131-TM-601 in adults with recurrent high-grade glioma

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12 December 2020

Potent pleiotropic anti-angiogenic effects of TM601, a synthetic chlorotoxin peptide.

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12 December 2020

Epidemiology of invasive candidiasis: a persistent public health problem

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12 December 2020

Scorpion venom-induced neutrophilia is inhibited by a PAF receptor antagonist in the rat

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12 December 2020

Imaging glioma extent with 131I-TM-601.

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12 December 2020

A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library

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12 December 2020

Preparation and in vitro evaluation of 131I-BmK CT as a glioma-targeted agent

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12 December 2020

Chlorotoxin-Fc fusion inhibits release of MMP-2 from pancreatic cancer cells.

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12 December 2020

Chloride channel-mediated brain glioma targeting of chlorotoxin-modified doxorubicine-loaded liposomes

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12 December 2020

Quantum dot mediated imaging of atherosclerosis

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12 December 2020

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12 December 2020

Biophysical and pharmacological characterization of chloride currents in human astrocytoma cells

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12 December 2020

Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation

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12 December 2020

Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus

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12 December 2020

Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis?

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12 December 2020

Virucidal activity of a scorpion venom peptide variant mucroporin-M1 against measles, SARS-CoV and influenza H5N1 viruses.

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12 December 2020

The many futures for cell-penetrating peptides: how soon is now?

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12 December 2020

APD2: the updated antimicrobial peptide database and its application in peptide design

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12 December 2020

Vejovine, a new antibiotic from the scorpion venom of Vaejovis mexicanus.

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12 December 2020

Solution structure of BmKTX, a K+ blocker toxin from the Chinese scorpion Buthus Martensi

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12 December 2020

Purification, characterization, and bioactivity of a new analgesic-antitumor peptide from Chinese scorpion Buthus martensii Karsch.

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12 December 2020

Inhibition of metastatic tumor growth and metastasis via targeting metastatic breast cancer by chlorotoxin-modified liposomes

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12 December 2020

Parabutoporin, a cationic amphipathic peptide from scorpion venom: much more than an antibiotic

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12 December 2020

Apoptogenic peptides from Tityus discrepans scorpion venom acting against the SKBR3 breast cancer cell line

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12 December 2020

Characterization of two linear cationic antimalarial peptides in the scorpion Mesobuthus eupeus

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12 December 2020

Activation of the complement system and leukocyte recruitment by Tityus serrulatus scorpion venom

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12 December 2020

In vitro anticancer effect of venom from Cuban scorpion Rhopalurus junceus against a panel of human cancer cell lines

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12 December 2020

Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channels

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12 December 2020

Structure, function, and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes

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12 December 2020

A high molecular weight protein Bengalin from the Indian black scorpion (Heterometrus bengalensis C.L. Koch) venom having antiosteoporosis activity in female albino rats.

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12 December 2020

Serum levels of cytokines in patients envenomed by Tityus serrulatus scorpion sting

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12 December 2020

Peptide T, a novel bradykinin potentiator isolated from Tityus serrulatus scorpion venom

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12 December 2020

Chemical synthesis and characterization of maurocalcine, a scorpion toxin that activates Ca(2+) release channel/ryanodine receptors

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12 December 2020

Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion

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12 December 2020

Human astrocytoma cells express a unique chloride current.

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12 December 2020

NMR sequential assignments and solution structure of chlorotoxin, a small scorpion toxin that blocks chloride channels

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12 December 2020

Anti-HIV-1 activity of a new scorpion venom peptide derivative Kn2-7

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12 December 2020

Alpha-helical cationic antimicrobial peptides: relationships of structure and function

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12 December 2020

The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies

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12 December 2020

An overview of toxins and genes from the venom of the Asian scorpion Buthus martensi Karsch

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12 December 2020

Chlorotoxin, a scorpion-derived peptide, specifically binds to gliomas and tumors of neuroectodermal origin

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12 December 2020

Toxin gamma from Tityus serrulatus scorpion venom plays an essential role in immunomodulation of macrophages

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12 December 2020

Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2

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12 December 2020

Mucroporin, the first cationic host defense peptide from the venom of Lychas mucronatus

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12 December 2020

A novel amphipathic linear peptide with both insect toxicity and antimicrobial activity from the venom of the scorpion Isometrus maculatus

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12 December 2020

Development of transgenic fungi that kill human malaria parasites in mosquitoes

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12 December 2020

Structural basis of a potent peptide inhibitor designed for Kv1.3 channel, a therapeutic target of autoimmune disease

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12 December 2020

Immune cells recruitment and activation by Tityus serrulatus scorpion venom

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12 December 2020

TLR2, TLR4 and CD14 recognize venom-associated molecular patterns from Tityus serrulatus to induce macrophage-derived inflammatory mediators

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12 December 2020

Identification of BmKAPi, a novel type of scorpion venom peptide with peculiar disulfide bridge pattern from Buthus martensii Karsch

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12 December 2020

Targeted delivery of antitumoral therapy to glioma and other malignancies with synthetic chlorotoxin (TM-601).

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12 December 2020

Bradykinin-potentiating peptides: beyond captopril.

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12 December 2020

BmKCT toxin inhibits glioma proliferation and tumor metastasis.

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12 December 2020

BK channel blockers inhibit potassium-induced proliferation of human astrocytoma cells

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12 December 2020

Hadrurin, a new antimicrobial peptide from the venom of the scorpion Hadrurus aztecus.

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12 December 2020

Mining on scorpion venom biodiversity

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12 December 2020

The antimicrobial peptide parabutoporin competes with p47(phox) as a PKC-substrate and inhibits NADPH oxidase in human neutrophils

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12 December 2020

Enhanced antimicrobial activity of novel synthetic peptides derived from vejovine and hadrurin

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12 December 2020

Quantitative evaluation of the cell penetrating properties of an iodinated Tyr-L-maurocalcine analog.

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12 December 2020

Scorpine, an anti-malaria and anti-bacterial agent purified from scorpion venom

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12 December 2020

Antiviral strategies: the present and beyond.

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12 December 2020

K(+) channel-dependent migration of fibroblasts and human melanoma cells

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12 December 2020

Cationic peptides from scorpion venom can stimulate and inhibit polymorphonuclear granulocytes

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12 December 2020

Scorpion venom peptides without disulfide bridges.

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12 December 2020

Inhibition of spontaneous neutrophil apoptosis by parabutoporin acts independently of NADPH oxidase inhibition but by lipid raft-dependent stimulation of Akt.

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12 December 2020

In vivo bio-imaging using chlorotoxin-based conjugates

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12 December 2020

K+ channel blockers: novel tools to inhibit T cell activation leading to specific immunosuppression

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12 December 2020

Tityus serrulatus venom and toxins Ts1, Ts2 and Ts6 induce macrophage activation and production of immune mediators

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12 December 2020

Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo

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12 December 2020

Apoptosis induction in human leukemic cells by a novel protein Bengalin, isolated from Indian black scorpion venom: through mitochondrial pathway and inhibition of heat shock proteins

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12 December 2020

Designing antimicrobial peptides: form follows function.

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12 December 2020

Scorpion venom and the inflammatory response

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12 December 2020

Vm24, a natural immunosuppressive peptide, potently and selectively blocks Kv1.3 potassium channels of human T cells

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12 December 2020

Tumor-targeted Chlorotoxin-coupled Nanoparticles for Nucleic Acid Delivery to Glioblastoma Cells: A Promising System for Glioblastoma Treatment.

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12 December 2020

Antimicrobial peptides from arachnid venoms and their microbicidal activity in the presence of commercial antibiotics.

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12 December 2020

Global malaria mortality between 1980 and 2010: a systematic analysis

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12 December 2020

Cationic host defence peptides: innate immune regulatory peptides as a novel approach for treating infections.

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12 December 2020

Adenovirus-mediated expression of BmK CT suppresses growth and invasion of rat C6 glioma cells

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12 December 2020

Regulation of multidrug resistance in pathogenic fungi

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12 December 2020

From antimicrobial to anticancer peptides. A review

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12 December 2020

Cell penetration properties of a highly efficient mini maurocalcine Peptide

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12 December 2020

Characterization of BmKbpp, a multifunctional peptide from the Chinese scorpion Mesobuthus martensii Karsch: gaining insight into a new mechanism for the functional diversification of scorpion venom peptides

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12 December 2020

New antibiotic agents in the pipeline and how they can help overcome microbial resistance

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12 December 2020

Antimicrobial and cytolytic peptides of venomous arthropods

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12 December 2020

Scorpion and spider venom peptides: gene cloning and peptide expression.

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12 December 2020

Voltage-gated sodium channel modulation by scorpion alpha-toxins

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12 December 2020

Tityus serrulatus Hypotensins: a new family of peptides from scorpion venom.

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12 December 2020

Natural roles of antimicrobial peptides in microbes, plants and animals.

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12 December 2020

Identification and functional characterization of novel scorpion venom peptides with no disulfide bridge from Buthus martensii Karsch

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12 December 2020

Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies

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12 December 2020

Molecular mechanisms of antibacterial multidrug resistance

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12 December 2020

Isolation and characterization of a hyaluronidase from the venom of Chinese red scorpion Buthus martensi

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12 December 2020

High levels of stromal hyaluronan predict poor disease outcome in epithelial ovarian cancer

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12 December 2020

The emerging fungal threat

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12 December 2020

Charybdotoxin is a new member of the K+ channel toxin family that includes dendrotoxin I and mast cell degranulating peptide

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12 December 2020

K+ channels as targets for specific immunomodulation

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12 December 2020

Role for calcium-activated potassium channels (BK) in growth control of human malignant glioma cells

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12 December 2020

Balance between pro- and anti-inflammatory cytokines in mice treated with Centruroides noxius scorpion venom.

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12 December 2020

Antimicrobial peptides from scorpion venoms

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12 December 2020

Maurocalcine as a non toxic drug carrier overcomes doxorubicin resistance in the cancer cell line MDA-MB 231

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12 December 2020

Chlorotoxin-conjugated nanoparticles as potential glioma-targeted drugs

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12 December 2020

Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus.

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12 December 2020

Scorpion toxins targeted against the sarcoplasmic reticulum Ca(2+)-release channel of skeletal and cardiac muscle

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12 December 2020

The gene cloning and sequencing of Bm-12, a chlorotoxin-like peptide from the scorpion Buthus martensi Karsch.

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12 December 2020

Ctriporin, a new anti-methicillin-resistant Staphylococcus aureus peptide from the venom of the scorpion Chaerilus tricostatus

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12 December 2020

[Potential of cell penetrating peptides for cell drug delivery]

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12 December 2020

Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases

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12 December 2020

Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides

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12 December 2020

Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator.

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12 December 2020

A bradykinin-potentiating peptide (peptide K12) isolated from the venom of Egyptian scorpion Buthus occitanus

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12 December 2020

Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels

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12 December 2020

Analgesic-antitumor peptide inhibits proliferation and migration of SHG-44 human malignant glioma cells

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12 December 2020

Antimicrobial peptides from scorpion venom induce Ca2+ signaling in HL-60 cells

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12 December 2020

Candida tropicalis in human disease

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12 December 2020

10.1016/J.TOXICON.2014.11.233

Identifiers

DOI

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1 September 2017

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PubMed ID

25432067