Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet (Q38282979)

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English	Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet	scientific article

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scholarly article

1 reference

Europe PubMed Central

1 September 2017

Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet (English)

1 reference

Europe PubMed Central

1 September 2017

Cytomegalovirus

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Sheng-Xiang Lin

object named as

Sheng-Xiang Lin

4

0 references

5

object named as

Guy Boivin

1 reference

Europe PubMed Central

1 September 2017

author name string

Christian Gilbert

1

1 reference

Europe PubMed Central

1 September 2017

Arezki Azzi

2

1 reference

Europe PubMed Central

1 September 2017

Nathalie Goyette

3

1 reference

Europe PubMed Central

1 September 2017

language of work or name

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publication date

27 June 2011

1 reference

Europe PubMed Central

1 September 2017

Antimicrobial Agents and Chemotherapy

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Europe PubMed Central

1 September 2017

55

1 reference

Europe PubMed Central

1 September 2017

4019-4027

1 reference

Europe PubMed Central

1 September 2017

9

1 reference

Europe PubMed Central

1 September 2017

Antiviral drug resistance of human cytomegalovirus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165324

6 September 2017

Recombinant phenotyping of cytomegalovirus UL97 kinase sequence variants for ganciclovir resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165324

6 September 2017

A new tool linking human cytomegalovirus drug resistance mutations to resistance phenotypes

1 reference

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Accelerated evolution of maribavir resistance in a cytomegalovirus exonuclease domain II mutant

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6 September 2017

Multidrug resistance conferred by novel DNA polymerase mutations in human cytomegalovirus isolates

1 reference

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6 September 2017

CUPSAT: prediction of protein stability upon point mutations.

1 reference

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6 September 2017

Optimal description of a protein structure in terms of multiple groups undergoing TLS motion

1 reference

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6 September 2017

Human cytomegalovirus resistance to antiviral drugs

1 reference

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How evolution of mutations conferring drug resistance affects viral dynamics and clinical outcomes of cytomegalovirus-infected hematopoietic cell transplant recipients

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6 September 2017

The influence of protease inhibitor resistance profiles on selection of HIV therapy in treatment-naive patients.

1 reference

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Drug resistance in HIV-1 protease: Flexibility-assisted mechanism of compensatory mutations

1 reference

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One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products

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A standardized plaque reduction assay for determination of drug susceptibilities of cytomegalovirus clinical isolates

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6 September 2017

Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity.

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Human cytomegalovirus tegument protein pp71 (ppUL82) enhances the infectivity of viral DNA and accelerates the infectious cycle

1 reference

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Gene disruption in Escherichia coli: TcR and KmR cassettes with the option of Flp-catalyzed excision of the antibiotic-resistance determinant

1 reference

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6 September 2017

Metabolic activation of the nucleoside analog 9-[( 2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine in human diploid fibroblasts infected with human cytomegalovirus

1 reference

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6 September 2017

A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165324

6 September 2017

Interstrain variation in the human cytomegalovirus DNA polymerase sequence and its effect on genotypic diagnosis of antiviral drug resistance. Adult AIDS Clinical Trials Group CMV Laboratories

1 reference

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Differentiation between polymorphisms and resistance-associated mutations in human cytomegalovirus DNA polymerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165324

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Human cytomegalovirus with IE-2 (UL122) deleted fails to express early lytic genes

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Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165324

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Fluorescence-based assay for phenotypic characterization of human cytomegalovirus polymerase mutations regarding drug susceptibility and viral replicative fitness

1 reference

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New reporter cell line to evaluate the sequential emergence of multiple human cytomegalovirus mutations during in vitro drug exposure

1 reference

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14 September 2017

Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recov

1 reference

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Identification of enzymes catalyzing two-step phosphorylation of cidofovir and the effect of cytomegalovirus infection on their activities in host cells

1 reference

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Herpes simplex virus type 1 DNA polymerase. Mutational analysis of the 3'-5'-exonuclease domain

1 reference

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Recombinant phenotyping of cytomegalovirus sequence variants detected after 200 or 100 days of valganciclovir prophylaxis

1 reference

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Growth and drug resistance phenotypes resulting from cytomegalovirus DNA polymerase region III mutations observed in clinical specimens

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High-level resistance of cytomegalovirus to ganciclovir is associated with alterations in both the UL97 and DNA polymerase genes

1 reference

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Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165324

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Contrasting effects on ganciclovir susceptibility and replicative capacity of two mutations at codon 466 of the human cytomegalovirus UL97 gene

1 reference

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Incidence and characterization of cytomegalovirus resistance mutations among pediatric solid organ transplant patients who received valganciclovir prophylaxis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165324

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Cytomegalovirus resistance in solid organ transplant recipients treated with intravenous ganciclovir or oral valganciclovir

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165324

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Crystal structure of the herpes simplex virus 1 DNA polymerase

1 reference

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Clinical impact of ganciclovir-resistant cytomegalovirus infections in solid organ transplant patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165324

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Absence of cytomegalovirus-resistance mutations after valganciclovir prophylaxis, in a prospective multicenter study of solid-organ transplant recipients

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165324

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Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165324

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Mutations conferring foscarnet resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165324

31 August 2018

High incidence of ganciclovir-resistant cytomegalovirus infection among lung transplant recipients receiving preemptive therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165324

31 August 2018

Rate of emergence of cytomegalovirus (CMV) mutations in leukocytes of patients with acquired immunodeficiency syndrome who are receiving valganciclovir as induction and maintenance therapy for CMV retinitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165324

31 August 2018

Longitudinal observations on mutations conferring ganciclovir resistance in patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis: The Cytomegalovirus and Viral Resistance Study Group Report Number 8.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165324

31 August 2018

Variations in the cytomegalovirus DNA polymerase and phosphotransferase genes in relation to foscarnet and ganciclovir sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165324

31 August 2018

Emergence of ganciclovir-resistant cytomegalovirus disease among recipients of solid-organ transplants.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165324

31 August 2018

Resistance to HIV protease inhibitors

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31 August 2018

A point mutation in the human cytomegalovirus DNA polymerase gene selected in vitro by cidofovir confers a slow replication phenotype in cell culture

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165324

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Evolution of mutations conferring multidrug resistance during prophylaxis and therapy for cytomegalovirus disease

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A case of ganciclovir-resistant cytomegalovirus (CMV) retinitis in a patient with AIDS: longitudinal molecular analysis of the CMV viral load and viral mutations in blood compartments

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https://pubmed.ncbi.nlm.nih.gov/21709106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three-dimensional modeling of cytomegalovirus DNA polymerase and preliminary analysis of drug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/21709106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel mutation in the UL54 gene of human cytomegalovirus isolates that confers resistance to foscarnet

1 reference

https://pubmed.ncbi.nlm.nih.gov/21709106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of human cytomegalovirus (HCMV) UL97 mutations found in a valganciclovir/oral ganciclovir prophylactic trial by use of a bacterial artificial chromosome containing the HCMV genome

1 reference

https://pubmed.ncbi.nlm.nih.gov/21709106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiviral treatment of cytomegalovirus infection and resistant strains

1 reference

https://pubmed.ncbi.nlm.nih.gov/21709106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiviral susceptibilities and analysis of UL97 and DNA polymerase sequences of clinical cytomegalovirus isolates from immunocompromised patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/21709106

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1128/AAC.00334-11

1 reference

Europe PubMed Central

1 September 2017

1 reference

Europe PubMed Central

1 September 2017

1 reference

Europe PubMed Central

1 September 2017

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