Probing the limits of electrostatic catalysis by uracil DNA glycosylase using transition state mimicry and mutagenesis. (Q38291765)

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7 December 2019

title

Probing the limits of electrostatic catalysis by uracil DNA glycosylase using transition state mimicry and mutagenesis (English)

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7 December 2019

2

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7 December 2019

author name string

Yu Lin Jiang

series ordinal

1

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7 December 2019

Yoshitaka Ichikawa

series ordinal

3

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7 December 2019

James T Stivers

series ordinal

4

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7 December 2019

language of work or name

English

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publication date

21 February 2002

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Journal of Biological Chemistry

7 December 2019

published in

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7 December 2019

volume

277

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7 December 2019

issue

18

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7 December 2019

page(s)

15385-15392

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The depth of chemical time and the power of enzymes as catalysts.

7 December 2019

cites work

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Electrostatic origin of the catalytic power of enzymes and the role of preorganized active sites

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Heteronuclear NMR and crystallographic studies of wild-type and H187Q Escherichia coli uracil DNA glycosylase: electrophilic catalysis of uracil expulsion by a neutral histidine 187

21 January 2018

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Escherichia coli uracil DNA glycosylase: NMR characterization of the short hydrogen bond from His187 to uracil O2.

21 January 2018

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Kinetic mechanism of damage site recognition and uracil flipping by Escherichia coli uracil DNA glycosylase

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Naphthalene, Phenanthrene, and Pyrene as DNA Base Analogues: Synthesis, Structure, and Fluorescence in DNA

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Stressing-out DNA? The contribution of serine-phosphodiester interactions in catalysis by uracil DNA glycosylase

21 January 2018

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Turning On uracil-DNA glycosylase using a pyrene nucleotide switch

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Reconstructing the substrate for uracil DNA glycosylase: tracking the transmission of binding energy in catalysis

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Uracil-DNA glycosylase acts by substrate autocatalysis

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Suppression of intestinal polyposis in Apc(delta 716) knockout mice by an additional mutation in the cytosolic phospholipase A(2) gene

21 January 2018

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Kinetic isotope effect studies of the reaction catalyzed by uracil DNA glycosylase: evidence for an oxocarbenium ion-uracil anion intermediate

21 January 2018

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Raman spectroscopy of uracil DNA glycosylase-DNA complexes: insights into DNA damage recognition and catalysis

21 January 2018

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1-Azaribofuranoside analogues as designed inhibitors of purine nucleoside phosphorylase. Synthesis and biological evaluation

21 January 2018

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4-Oxalocrotonate tautomerase: pH dependence of catalysis and pKa values of active site residues

21 January 2018

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Selective inhibition of herpes simplex virus type-1 uracil-DNA glycosylase by designed substrate analogs

21 January 2018

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