Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia. (Q38306307)

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2 November 2019

title

Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia (English)

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2 November 2019

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6

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2 November 2019

author name string

Gueven N

1

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2 November 2019

Keating KE

2

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2 November 2019

Chen P

3

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2 November 2019

Fukao T

4

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2 November 2019

Khanna KK

5

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2 November 2019

Rodemann PH

7

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Lavin MF

8

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2 November 2019

language of work or name

English

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publication date

15 November 2000

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Journal of Biological Chemistry

2 November 2019

published in

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2 November 2019

volume

276

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2 November 2019

issue

12

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2 November 2019

page(s)

8884-8891

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describes a project that uses

2 November 2019

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A single ataxia telangiectasia gene with a product similar to PI-3 kinase

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https://api.crossref.org/works/10.1074%2FJBC.M006190200

The genetic defect in ataxia-telangiectasia

21 January 2018

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Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks

21 January 2018

1 reference

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Comparison of kinetics of X-ray-induced cell killing in normal, ataxia telangiectasia and hereditary retinoblastoma fibroblasts

21 January 2018

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DNA damage induces phosphorylation of the amino terminus of p53

21 January 2018

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ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

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ATM associates with and phosphorylates p53: mapping the region of interaction

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms

21 January 2018

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The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage

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Upregulation of ATM in sclerosing adenosis of the breast

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Mutations revealed by sequencing the 5' half of the gene for ataxia telangiectasia.

21 January 2018

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Identification and characterization of a new gene physically linked to the ATM gene

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The structure and organization of the human NPAT gene

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ATM binds to beta-adaptin in cytoplasmic vesicles

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The effect of ionizing radiation on signal transduction: antibodies to EGF receptor sensitize A431 cells to radiation

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Growth-inhibitory and growth-stimulatory effects of epidermal growth factor on human breast cancer cell line, MDA.MB.436: dependence on culture conditions

21 January 2018

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Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype

21 January 2018

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Molecular basis of selective IgG2 deficiency. The mutated membrane-bound form of gamma2 heavy chain caused complete IGG2 deficiency in two Japanese siblings

21 January 2018

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Mouse cdc21 only 0.5 kb upstream from dna-pkcs in a head-to-head organization: an implication of co-evolution of ATM family members and cell cycle regulating genes

21 January 2018

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ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia

21 January 2018

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ATM: from gene to function

21 January 2018

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Lack of correlation between ATM protein expression and tumour cell radiosensitivity

21 January 2018

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DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

21 January 2018

1 reference

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Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription

21 January 2018

1 reference

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

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Molecular cloning of cDNA encoding mouse Cdc21 and CDC46 homologs and characterization of the products: physical interaction between P1 (MCM3) and CDC46 proteins

21 January 2018

1 reference

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MCM4 and PRKDC, human genes encoding proteins MCM4 and DNA-PKcs, are close neighbours located on chromosome 8q12→q13

21 January 2018

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Nitric oxide upregulates expression of DNA-PKcs to protect cells from DNA-damaging anti-tumour agents

21 January 2018

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Epidermal growth factor and okadaic acid stimulate Sp1 proteolysis

21 January 2018

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Growth/cell cycle regulation of Sp1 phosphorylation

21 January 2018

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Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M006190200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11080496%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

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