Growth hormone (GH)-independent dimerization of GH receptor by a leucine zipper results in constitutive activation (Q38311941)

2 September 2017

title

Growth hormone (GH)-independent dimerization of GH receptor by a leucine zipper results in constitutive activation (English)

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2 September 2017

Behncken SN

1

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2 September 2017

Billestrup N

2

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2 September 2017

Brown R

3

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2 September 2017

Amstrup J

4

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2 September 2017

Conway-Campbell B

5

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2 September 2017

Waters MJ

6

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2 September 2017

language of work or name

English

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publication date

1 June 2000

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Journal of Biological Chemistry

2 September 2017

published in

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2 September 2017

volume

275

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2 September 2017

issue

22

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2 September 2017

page(s)

17000-17007

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Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule

2 September 2017

cites work

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Activation of chimeric and full-length growth hormone receptors by growth hormone receptor monoclonal antibodies. A specific conformational change may be required for full-length receptor signaling.

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Conformational changes required in the human growth hormone receptor for growth hormone signaling.

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Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation

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Activation of the erythropoietin (EPO) receptor by bivalent anti-EPO receptor antibodies

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Preferential heterodimer formation by isolated leucine zippers from fos and jun

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A growth hormone agonist produced by targeted mutagenesis at binding site 1. Evidence that site 1 regulates bioactivity

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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Early responses of trans-activating factors to growth hormone in preadipocytes: differential regulation of CCAAT enhancer-binding protein-beta (C/EBP beta) and C/EBP delta

21 January 2018

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Aspartate 171 is the major primate-specific determinant of human growth hormone. Engineering porcine growth hormone to activate the human receptor.

21 January 2018

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Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA

21 January 2018

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Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

21 January 2018

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Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution

21 January 2018

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Efficiency of signalling through cytokine receptors depends critically on receptor orientation

21 January 2018

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An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation

21 January 2018

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Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

21 January 2018

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Regions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptor

21 January 2018

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Dimerization of the extracellular domain of the erythropoietin (EPO) receptor by EPO: one high-affinity and one low-affinity interaction

21 January 2018

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Functional replacement of cytokine receptor extracellular domains by leucine zippers

21 January 2018

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Receptor dimerization determines the effects of growth hormone in primary rat adipocytes and cultured human IM-9 lymphocytes

21 January 2018

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Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling

21 January 2018

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Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.275.22.17000

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2 September 2017

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