Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies (Q38315557)

2 September 2017

Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies (English)

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2 September 2017

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Müller-Newen G

1

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2 September 2017

Küster A

2

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2 September 2017

Wijdenes J

3

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2 September 2017

Schaper F

4

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2 September 2017

Heinrich PC

5

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2 September 2017

language of work or name

English

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publication date

1 February 2000

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Journal of Biological Chemistry

2 September 2017

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2 September 2017

275

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2 September 2017

4579-4586

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2 September 2017

7

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Regulation of signal transduction and signal diversity by receptor oligomerization

2 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Dimerization of cell surface receptors in signal transduction

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

The receptor for ciliary neurotrophic factor

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Molecular cloning and expression of an IL-6 signal transducer, gp130

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Crystal structure of a cytokine-binding region of gp130.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

The membrane distal half of gp130 is responsible for the formation of a ternary complex with IL-6 and the IL-6 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Hematopoietic receptor complexes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

gp130 transducing receptor cross-linking is sufficient to induce interleukin-6 type responses

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Production of hybridoma growth factor by human monocytes.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Human recombinant dimeric IL-6 binds to its receptor as detected by anti-IL-6 monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Interleukin-6: structure-function relationships.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

The family of the IL-6-type cytokines: specificity and promiscuity of the receptor complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Efficiency of signalling through cytokine receptors depends critically on receptor orientation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Structural design and molecular evolution of a cytokine receptor superfamily

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 (IL-6).IL-6 receptor.gp130 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Activation of the gp130 signaling pathway by monoclonal antibodies directed against the gp130 molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

Erythropoietin receptor activation by a ligand-induced conformation change

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.7.4579

21 January 2018

Identifiers

DOI

10.1074/JBC.275.7.4579

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2 September 2017

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