Swedish mutant APP suppresses osteoblast differentiation and causes osteoporotic deficit, which are ameliorated by N-acetyl-L-cysteine. (Q38315769)

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29 February 2020

title

Swedish mutant APP suppresses osteoblast differentiation and causes osteoporotic deficit, which are ameliorated by N-acetyl-L-cysteine (English)

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29 February 2020

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2

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29 February 2020

author name string

Wen-Fang Xia

1

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29 February 2020

Cui Shun

3

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29 February 2020

Shan Xiong

4

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29 February 2020

Lei Xiong

5

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29 February 2020

Xing-Ming Shi

6

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29 February 2020

Lin Mei

7

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29 February 2020

Wen-Cheng Xiong

8

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29 February 2020

publication date

1 October 2013

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Journal of Bone and Mineral Research

29 February 2020

published in

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29 February 2020

volume

28

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29 February 2020

issue

10

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29 February 2020

page(s)

2122-2135

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A4 amyloid protein deposition and the diagnosis of Alzheimer's disease: prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathologic techniques.

29 February 2020

cites work

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High prevalence of vitamin D deficiency and reduced bone mass in elderly women with Alzheimer's disease.

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Pathogenic accumulation of APP in fast twitch muscle of IBM patients and a transgenic model

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Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy.

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Cerebral amyloid angiopathy in the aetiology and immunotherapy of Alzheimer disease

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APPswe/Aβ regulation of osteoclast activation and RAGE expression in an age-dependent manner.

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Regulation of osteoclast function and bone mass by RAGE.

21 January 2018

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HMGB1 regulates RANKL-induced osteoclastogenesis in a manner dependent on RAGE.

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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Expression pattern of a mini human PrP gene promoter in transgenic mice.

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Regulation of mesenchymal stem cell osteogenic differentiation by glucocorticoid-induced leucine zipper (GILZ).

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VPS35 haploinsufficiency increases Alzheimer's disease neuropathology.

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Learning and memory in transgenic mice modeling Alzheimer's disease

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Mouse models of Alzheimer's disease: insight into treatment

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Gamma-secretase-dependent cleavage of amyloid precursor protein regulates osteoblast behavior.

21 January 2018

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Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis.

21 January 2018

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Striatal neuroprotection from neonatal hypoxia-ischemia in piglets by antioxidant treatment with EUK-134 or edaravone

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Elevation of glutathione as a therapeutic strategy in Alzheimer disease

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γ-secretase inhibitors and modulators for the treatment of Alzheimer's disease: disappointments and hopes

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Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids

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What old means to bone

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FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts

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FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice

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Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton

21 January 2018

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Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription.

21 January 2018

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N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis

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Apolipoprotein E and Alzheimer's disease. A role in amyloid catabolism

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12 December 2020

Molecular neuropathology of Alzheimer's disease.

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12 December 2020

Elevated levels of amyloid precursor protein in muscle of patients with amyotrophic lateral sclerosis and a mouse model of the disease

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12 December 2020

Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis

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12 December 2020

Alzheimer's disease and osteoporosis: common risk factors or one condition predisposing to the other?

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12 December 2020

Genomic approaches to bone and joint diseases. New insights into molecular mechanisms underlying protective effects of vitamin K on bone health

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12 December 2020

Oxidative modification of brain proteins in Alzheimer's disease: perspective on future studies based on results of redox proteomics studies

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12 December 2020

Alzheimer's disease: the amyloid cascade hypothesis: an update and reappraisal.

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12 December 2020

Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees

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12 December 2020

Amyloid precursor protein (APP) and beta A4 amyloid in Alzheimer's disease and Down syndrome

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12 December 2020

Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies.

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12 December 2020

Potential in vivo amelioration by N-acetyl-L-cysteine of oxidative stress in brain in human double mutant APP/PS-1 knock-in mice: toward therapeutic modulation of mild cognitive impairment

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12 December 2020

Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferation

1 reference

12 December 2020

Identifiers

DOI

10.1002/JBMR.1954

1 reference

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release_76d447ya4ffutdr7ktpdoq7qra

29 February 2020

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/76d447ya4ffutdr7ktpdoq7qra

24 November 2022

mapped directly with Wikidata item

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