Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy (Q38318433)

2 September 2017

Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy (English)

1 reference

2 September 2017

alpha,alpha-trehalose

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author name string

Janet E Davies

series ordinal

1

1 reference

PubMed ID

16311254

2 September 2017

Sovan Sarkar

series ordinal

2

1 reference

PubMed ID

16311254

2 September 2017

David C Rubinsztein

series ordinal

3

1 reference

2 September 2017

25 November 2005

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2 September 2017

Human Molecular Genetics

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2 September 2017

15

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2 September 2017

23-31

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2 September 2017

1

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Alanine tracts: the expanding story of human illness and trinucleotide repeats

2 September 2017

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

Short GCG expansions in the PABP2 gene cause oculopharyngeal muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

Nuclear inclusions in oculopharyngeal muscular dystrophy consist of poly(A) binding protein 2 aggregates which sequester poly(A) RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

A molecular pathogenesis for transcription factor associated poly-alanine tract expansions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

Mammalian, yeast, bacterial, and chemical chaperones reduce aggregate formation and death in a cell model of oculopharyngeal muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

Involvement of the ubiquitin-proteasome pathway and molecular chaperones in oculopharyngeal muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

Congo red, doxycycline, and HSP70 overexpression reduce aggregate formation and cell death in cell models of oculopharyngeal muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

Role of trehalose phosphate synthase and trehalose during hypoxia: from flies to mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

Multiple effects of trehalose on protein folding in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

Inhibition of insulin amyloid formation by small stress molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

Influence of molecular and chemical chaperones on protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

A small stress protein acts synergistically with trehalose to confer desiccation tolerance on mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

A small heat-shock protein, p26, from the crustacean Artemia protects mammalian cells (Cos-1) against oxidative damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

Human platelets loaded with trehalose survive freeze-drying

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

Deciphering the cellular pathway for transport of poly(A)-binding protein II

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

Formation of an extremely stable polyalanine beta-sheet macromolecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

Polyalanine-based peptides as models for self-associated beta-pleated-sheet complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

Poly-(L-alanine) expansions form core beta-sheets that nucleate amyloid assembly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

Trehalose: a review of properties, history of use and human tolerance, and results of multiple safety studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

A molecular investigation of true dominance in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

Loading Human Mesenchymal Stem Cells with Trehalose by Fluid-Phase Endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI422

21 January 2018

Identifiers

DOI

10.1093/HMG/DDI422

1 reference

2 September 2017

1 reference

PubMed ID

16311254