Molecular analysis of yeast and human type II topoisomerases. Enzyme-DNA and drug interactions. (Q38320285)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10497180%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

title

Molecular analysis of yeast and human type II topoisomerases. Enzyme-DNA and drug interactions (English)

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31 October 2019

2

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31 October 2019

author name string

D Strumberg

1

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31 October 2019

J Dong

3

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31 October 2019

K W Kohn

4

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31 October 2019

Y Pommier

5

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31 October 2019

language of work or name

English

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publication date

1 October 1999

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Journal of Biological Chemistry

31 October 2019

published in

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31 October 2019

volume

274

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31 October 2019

issue

40

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31 October 2019

page(s)

28246-28255

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31 October 2019

1 reference

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Investigating the biological functions of DNA topoisomerases in eukaryotic cells

21 January 2018

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When good enzymes go bad: conversion of topoisomerase II to a cellular toxin by antineoplastic drugs

21 January 2018

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DNA topoisomerases: essential enzymes and lethal targets

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Drug resistance associated with altered DNA topoisomerase II.

21 January 2018

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Topoisomerase poisons: harnessing the dark side of enzyme mechanism.

21 January 2018

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Cellular determinants of sensitivity and resistance to DNA topoisomerase inhibitors

21 January 2018

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Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group

21 January 2018

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The molecular basis of quinolone action

21 January 2018

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Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex

21 January 2018

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DNA sequence selectivity of topoisomerases and topoisomerase poisons.

21 January 2018

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Apurinic sites are position-specific topoisomerase II poisons.

21 January 2018

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Using yeast to understand drugs that target topoisomerases.

21 January 2018

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Yeast as a model organism for studying the actions of DNA topoisomerase-targeted drugs

21 January 2018

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Type II DNA topoisomerases

21 January 2018

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Mutation of a conserved serine residue in a quinolone-resistant type II topoisomerase alters the enzyme-DNA and drug interactions.

21 January 2018

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Proteolysis patterns of epitopically labeled yeast DNA topoisomerase II suggest an allosteric transition in the enzyme induced by ATP binding

21 January 2018

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A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine.

21 January 2018

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Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide.

21 January 2018

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Induction of cleavage in topoisomerase I c-DNA by topoisomerase I enzymes from calf thymus and wheat germ in the presence and absence of camptothecin

21 January 2018

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Calcium-promoted DNA cleavage by eukaryotic topoisomerase II: trapping the covalent enzyme-DNA complex in an active form.

21 January 2018

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Conformational changes in DNA gyrase revealed by limited proteolysis.

21 January 2018

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Mapping drug interactions at the covalent topoisomerase II-DNA complex by bisantrene/amsacrine congeners.

21 January 2018

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DNA sequence specificity of mitoxantrone

21 January 2018

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Site-specific interaction of DNA gyrase with DNA

21 January 2018

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A mutation in yeast TOP2 homologous to a quinolone-resistant mutation in bacteria. Mutation of the amino acid homologous to Ser83 of Escherichia coli gyrA alters sensitivity to eukaryotic topoisomerase inhibitors

21 January 2018

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Structure and mechanism of DNA topoisomerase II

21 January 2018

1 reference

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Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands

21 January 2018

1 reference

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Identification of active site residues in the "GyrA" half of yeast DNA topoisomerase II.

21 January 2018

1 reference

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DNA cleavage is not required for the binding of quinolone drugs to the DNA gyrase-DNA complex

21 January 2018

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A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex

21 January 2018

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Using yeast to study resistance to topoisomerase II-targeting drugs.

21 January 2018

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The bis(naphthalimide) DMP-840 causes cytotoxicity by its action against eukaryotic topoisomerase II.

21 January 2018

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Topoisomerase II.etoposide interactions direct the formation of drug-induced enzyme-DNA cleavage complexes.

21 January 2018

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