Apoptosis promotes a caspase-induced amino-terminal truncation of IkappaBalpha that functions as a stable inhibitor of NF-kappaB. (Q38322916)

2 September 2017

Apoptosis promotes a caspase-induced amino-terminal truncation of IkappaBalpha that functions as a stable inhibitor of NF-kappaB. (English)

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2 September 2017

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J Y Reuther

1

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PubMed ID

10400699

2 September 2017

A S Baldwin

series ordinal

2

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PubMed ID

10400699

2 September 2017

language of work or name

English

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publication date

1 July 1999

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Journal of Biological Chemistry

2 September 2017

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2 September 2017

274

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2 September 2017

29

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2 September 2017

20664-20670

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Programmed cell death in animal development

2 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.274.29.20664

Human ICE/CED-3 protease nomenclature

21 January 2018

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Cell death: the significance of apoptosis

21 January 2018

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Caspases: intracellular signaling by proteolysis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.29.20664

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

21 January 2018

1 reference

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The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.29.20664

ICE family proteases: mediators of all apoptotic cell death?

21 January 2018

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Requirement of the caspase-3/CPP32 protease cascade for apoptotic death following cytokine deprivation in hematopoietic cells.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.29.20664

Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases.

21 January 2018

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DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.29.20664

MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.29.20664

DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.29.20664

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

21 January 2018

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The NF-kappa B and I kappa B proteins: new discoveries and insights

21 January 2018

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An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

21 January 2018

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Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

21 January 2018

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Suppression of TNF-alpha-induced apoptosis by NF-kappaB

21 January 2018

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TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

21 January 2018

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Identification and characterization of an IkappaB kinase

21 January 2018

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A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

21 January 2018

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IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

21 January 2018

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IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.29.20664

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

21 January 2018

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N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.29.20664

Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.29.20664

Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20664

Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.29.20664

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.29.20664

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.29.20664

Dependence and reversal of nitric oxide production on NF-kappa B in silica and lipopolysaccharide-induced macrophages

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.29.20664

Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.29.20664

The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20664

NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses

21 January 2018

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Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B

21 January 2018

1 reference

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Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis.

21 January 2018

1 reference

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NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20664

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control

21 January 2018

1 reference

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Phosphorylation of IkappaB-alpha inhibits its cleavage by caspase CPP32 in vitro

21 January 2018

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IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival

21 January 2018

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A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation

21 January 2018

1 reference

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Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.29.20664

Caspases: killer proteases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.29.20664

Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

21 January 2018

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Function and activation of NF-kappa B in the immune system

21 January 2018

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Interaction of the v-Rel oncoprotein with NF-kappaB and IkappaB proteins: heterodimers of a transformation-defective v-Rel mutant and NF-2 are functional in vitro and in vivo

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.274.29.20664

1 reference

2 September 2017

1 reference

PubMed ID

10400699