Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase (Q38323889)

2 September 2017

Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase (English)

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2 September 2017

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W C Liao

1

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2 September 2017

A Haimovitz-Friedman

2

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2 September 2017

R S Persaud

3

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2 September 2017

M McLoughlin

4

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2 September 2017

D Ehleiter

5

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2 September 2017

N Zhang

6

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2 September 2017

M Gatei

7

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2 September 2017

M Lavin

8

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2 September 2017

R Kolesnick

9

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2 September 2017

Z Fuks

10

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2 September 2017

language of work or name

English

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publication date

1 June 1999

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Journal of Biological Chemistry

2 September 2017

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2 September 2017

274

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2 September 2017

25

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2 September 2017

17908-17917

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The complexity of DNA damage: relevance to biological consequences

2 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Chromosomal aberrations and mortality of x-irradiated mammalian cells: emphasis on repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Proliferation Kinetics of X-irradiated Mouse L Cells Studied with Time-lapse Photography. II

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

DNA-dependent protein kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Cell-cycle signaling: Atm displays its many talents

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

The genetic defect in ataxia-telangiectasia

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Range of radiochemical damage to DNA with decay of iodine-125.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Identification of ataxia telangiectasia heterozygotes, a cancer prone population

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

p53 is required for radiation-induced apoptosis in mouse thymocytes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Induction of apoptosis by tumor suppressor genes and oncogenes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Partial rescue of the prophase I defects of Atm-deficient mice by p53 and p21 null alleles.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Signal transduction through lipid second messengers

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Fumonisin inhibition of de novo sphingolipid biosynthesis and cytotoxicity are correlated in LLC-PK1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Defective signaling through the B cell antigen receptor in Epstein-Barr virus-transformed ataxia-telangiectasia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Predominance of null mutations in ataxia-telangiectasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Gene dosage and complementation analysis of ataxia telangiectasia lymphoblastoid cell lines assayed by induced chromosome aberrations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

A Cytofluorometric Assay of Nuclear Apoptosis Induced in a Cell-Free System: Application to Ceramide-Induced Apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Evidence for a general relationship between the induced level of DNA double-strand breakage and cell-killing after X-irradiation of mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

The range of high LET effects from 125I decays

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Role of mitochondrial DNA in cell death induced by 125I decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Rdiotoxicity of intracellular 67Ga, 125I and 3H. Nuclear versus cytoplasmic radiation effects in murine L1210 leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Lethality of Auger electrons from the decay of bromine-77 in the DNA of mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Induction of sister-chromatid exchanges in fish exposed to Rhine water

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Defect in multiple cell cycle checkpoints in ataxia-telangiectasia postirradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Intact G2-phase checkpoint in cells of a human cell line lacking DNA-dependent protein kinase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Fatty acyl-Co A: sphingosine acyltransferase in bovine brain mitochondria: its solubilization and reconstitution onto the membrane lipid liposomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Sequential operation of ceramide synthesis and ICE cascade in CPT-11-initiated apoptotic death signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Thioredoxin peroxidase is a novel inhibitor of apoptosis with a mechanism distinct from that of Bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.25.17908

21 January 2018

Identifiers

DOI

10.1074/JBC.274.25.17908

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2 September 2017

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