Drug delivery of antisense molecules to the brain for treatment of Alzheimer's disease and cerebral AIDS. (Q38331415)

2 September 2017

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title

Drug delivery of antisense molecules to the brain for treatment of Alzheimer's disease and cerebral AIDS. (English)

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2 September 2017

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3

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2 September 2017

Boado RJ

1

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PubMed ID

9811482

2 September 2017

Tsukamoto H

series ordinal

2

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PubMed ID

9811482

2 September 2017

language of work or name

English

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publication date

1 November 1998

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Journal of Pharmaceutical Sciences

2 September 2017

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2 September 2017

87

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2 September 2017

11

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2 September 2017

1308-1315

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Antisense technology and prospects for therapy of viral infections and cancer

2 September 2017

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Oligonucleotides as modulators of cancer gene expression

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ANTISENSE oligonucleotides: a new tool in neuroscience

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Application of antisense DNA method for the study of molecular bases of brain function and behavior

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Antisense strategies in neurobiology

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Critical issues in the antisense inhibition of brain gene expression in vivo: experiences targetting the 5-HT1A receptor.

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Down-regulation of mGluR5 by antisense deoxynucleotides alters pharmacological responses to applications of ACPD in the rat hippocampus.

1 reference

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Stability, clearance, and disposition of intraventricularly administered oligodeoxynucleotides: implications for therapeutic application within the central nervous system

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Complete Inactivation of Target mRNA by Biotinylated Antisense Oligodeoxynucleotide-Avidin Conjugates

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Desialation of transferrin by rat liver endothelium

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Comparison of cellular binding and uptake of antisense phosphodiester, phosphorothioate, and mixed phosphorothioate and methylphosphonate oligonucleotides.

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Use of partially phosphorothioated "antisense" oligodeoxynucleotides for sequence-dependent modulation of hematopoiesis in culture

1 reference

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Mixed-backbone oligonucleotides as second generation antisense oligonucleotides: in vitro and in vivo studies

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Complete protection of antisense oligonucleotides against serum nuclease degradation by an avidin-biotin system

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In vivo treatment of human leukemia in a scid mouse model with c-myb antisense oligodeoxynucleotides

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7 January 2021

Review of in vivo pharmacokinetics and toxicology of phosphorothioate oligonucleotides.

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Stability of peptide nucleic acids in human serum and cellular extracts

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7 January 2021

Human blood-brain barrier transferrin receptor

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7 January 2021

Transferrin receptor on endothelium of brain capillaries

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7 January 2021

Vector-mediated delivery of a polyamide ("peptide") nucleic acid analogue through the blood-brain barrier in vivo

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7 January 2021

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7 January 2021

The molecular pathology of Alzheimer's disease

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7 January 2021

Morphology of blood-brain interfaces

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7 January 2021

Localization of amyloid beta protein messenger RNA in brains from patients with Alzheimer's disease.

1 reference

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Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

1 reference

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1 reference

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Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides

1 reference

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Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.

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Differential regulation of amyloid-beta-protein mRNA expression within hippocampal neuronal subpopulations in Alzheimer disease

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Distribution of precursor amyloid-beta-protein messenger RNA in human cerebral cortex: relationship to neurofibrillary tangles and neuritic plaques.

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Expression of the Alzheimer amyloid precursor gene transcripts in the human brain.

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7 January 2021

Studies of Amyloidβ-Protein Precursor Expression in Alzheimer's Disease

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Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease.

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Quantitative measurement of alternatively spliced amyloid precursor protein mRNA expression in Alzheimer's disease and normal brain by S1 nuclease protection analysis

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Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity

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Interleukin-1 stimulates the beta-amyloid precursor protein promoter

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Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells

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Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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Down-regulation of the amyloid protein precursor of Alzheimer's disease by antisense oligonucleotides reduces neuronal adhesion to specific substrata.

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7 January 2021

The AIDS dementia complex: I. Clinical features

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7 January 2021

The AIDS dementia complex: II. Neuropathology.

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Early penetration of the blood-brain-barrier by HIV.

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Human immunodeficiency virus type 1 infection of the brain

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Modulation of CD4 antigen on macrophages and microglia in rat brain

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Structural mechanisms of HIV drug resistance

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Saquinavir. A review of its pharmacology and clinical potential in the management of HIV infection

1 reference

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Protease inhibitors: a therapeutic breakthrough for the treatment of patients with human immunodeficiency virus

1 reference

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Antisense oligodeoxynucleotide phosphorothioate complementary to Gag mRNA blocks replication of human immunodeficiency virus type 1 in human peripheral blood cells

1 reference

7 January 2021

Restricted transport of 3'-azido-3'-deoxythymidine and dideoxynucleosides through the blood-brain barrier

1 reference

7 January 2021

Identifiers

DOI

10.1021/JS9800836

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2 September 2017

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PubMed ID

9811482