Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition. (Q38333574)

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5 January 2020

title

Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition (English)

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8

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author name string

X Yu

1

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S McCorkle

2

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M Wang

3

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Y Lee

4

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J Li

5

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A K Saha

6

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R H Unger

7

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publication date

1 November 2004

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volume

47

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issue

11

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page(s)

2012-2021

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https://scigraph.springernature.com/pub.10.1007/s00125-004-1570-9

5 January 2020

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cites work

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Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

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Ectopic fat accumulation: an important cause of insulin resistance in humans

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Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity

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The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

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Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats.

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Isoform-specific regulation of 5' AMP-activated protein kinase in skeletal muscle from obese Zucker (fa/fa) rats in response to contraction

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The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes

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Caloric restriction in obese pre-diabetic rats prevents beta-cell depletion, loss of beta-cell GLUT 2 and glucose incompetence

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Zucker and Wistar diabetic fatty rats show different response to adrenalectomy

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Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats

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Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulin

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Chronic treatment with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside increases insulin-stimulated glucose uptake and GLUT4 translocation in rat skeletal muscles in a fiber type-specific manner

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Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle

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AMP-activated protein kinase and hepatic genes involved in glucose metabolism

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AMPK activation increases uncoupling protein-3 expression and mitochondrial enzyme activities in rat muscle without fibre type transitions

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Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats

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Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

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Malonyl-CoA regulation in skeletal muscle: its link to cell citrate and the glucose-fatty acid cycle

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Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women

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Leptin receptor missense mutation in the fatty Zucker rat.

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5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase

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Direct antidiabetic effect of leptin through triglyceride depletion of tissues.

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Role of AMP-activated protein kinase in mechanism of metformin action

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AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target.

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Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes

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5-aminoimidazole-4-carboxy-amide-1-beta-D-ribofuranoside treatment ameliorates hyperglycaemia and hyperinsulinaemia but not dyslipidaemia in KKAy-CETP mice

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Evidence that down-regulation of beta-cell glucose transporters in non-insulin-dependent diabetes may be the cause of diabetic hyperglycemia

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Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats

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Insulin and contraction directly stimulate UCP2 and UCP3 mRNA expression in rat skeletal muscle in vitro

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Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships

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12 December 2020

AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats

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12 December 2020

Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise

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Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats

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Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression

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Substitution at codon 269 (glutamine --> proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat.

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Lipid abnormalities in tissues of the KKAy mouse: effects of pioglitazone on malonyl-CoA and diacylglycerol

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Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes

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In support of the roles of malonyl-CoA and carnitine acyltransferase I in the regulation of hepatic fatty acid oxidation and ketogenesis

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Lipotoxic heart disease in obese rats: implications for human obesity

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AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle

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12 December 2020

Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo

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12 December 2020

10.1007/S00125-004-1570-9

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15578153%20AND%20SRC:MED&resulttype=core&format=json

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5 January 2020

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