Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells. (Q38340158)

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15 February 2020

title

Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells (English)

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15 February 2020

2

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Pietro Luigi Poliani

3

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author name string

F Orzan

1

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F Pisati

4

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V Caldera

5

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F Menghi

6

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D Kapetis

7

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C Marras

8

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D Schiffer

9

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G Finocchiaro

10

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publication date

1 June 2011

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Neuropathology and Applied Neurobiology

15 February 2020

published in

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volume

37

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issue

4

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page(s)

381-394

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Stem cells and cancer; the polycomb connection

15 February 2020

cites work

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Roles of the EZH2 histone methyltransferase in cancer epigenetics

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The Polycomb group protein EZH2 directly controls DNA methylation

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A bivalent chromatin structure marks key developmental genes in embryonic stem cells

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Role of histone H3 lysine 27 methylation in Polycomb-group silencing

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Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma

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Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines

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Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells

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Epigenetic mechanisms in glioblastoma multiforme

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

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Analysis of probe level patterns in Affymetrix microarray data

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Neurospheres enriched in cancer stem-like cells are highly effective in eliciting a dendritic cell-mediated immune response against malignant gliomas.

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Histone deacetylase inhibitors deplete enhancer of zeste 2 and associated polycomb repressive complex 2 proteins in human acute leukemia cells

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Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation

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Suberoylanilide hydroxamic acid (SAHA) has potent anti-glioma properties in vitro, ex vivo and in vivo

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Suberoylanilide hydroxamic acid limits migration and invasion of glioma cells in two and three dimensional culture

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The role of the polycomb complex in silencing alpha-globin gene expression in nonerythroid cells

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Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood

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Continuous intracranial administration of suberoylanilide hydroxamic acid (SAHA) inhibits tumor growth in an orthotopic glioma model

21 January 2018

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21 January 2018

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EZH2 is essential for glioblastoma cancer stem cell maintenance

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EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast

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21 January 2018

Identifiers

DOI

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15 February 2020

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