Degradation of mutated bovine pancreatic trypsin inhibitor in the yeast vacuole suggests post-endoplasmic reticulum protein quality control (Q38345491)

2 September 2017

Degradation of mutated bovine pancreatic trypsin inhibitor in the yeast vacuole suggests post-endoplasmic reticulum protein quality control (English)

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2 September 2017

endoplasmic reticulum

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Christina M Coughlan

1

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2 September 2017

Jennifer L Walker

2

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2 September 2017

Jared C Cochran

3

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2 September 2017

K Dane Wittrup

4

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2 September 2017

Jeffrey L Brodsky

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2 September 2017

language of work or name

English

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publication date

26 January 2004

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Journal of Biological Chemistry

2 September 2017

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2 September 2017

279

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2 September 2017

15289-15297

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2 September 2017

15

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Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol

2 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.M309673200

Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Evolving questions and paradigm shifts in endoplasmic-reticulum-associated degradation (ERAD).

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M309673200

Yeast as a model system to investigate protein conformational diseases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M309673200

ER-associated degradation in protein quality control and cellular regulation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M309673200

The action of molecular chaperones in the early secretory pathway

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M309673200

Retro-translocation of proteins from the endoplasmic reticulum into the cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

ER quality control: towards an understanding at the molecular level

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

The variable domain of nonassembled Ig light chains determines both their half-life and binding to the chaperone BiP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Inhibition of immunoglobulin folding and secretion by dominant negative BiP ATPase mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Assembly of ER-associated protein degradation in vitro: dependence on cytosol, calnexin, and ATP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Intracellular functions of N-linked glycans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Dependence of endoplasmic reticulum-associated degradation on the peptide binding domain and concentration of BiP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Cell biology. Protein degradation unlocked

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M309673200

Building bridges: disulphide bond formation in the cell

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M309673200

Protein disulphide isomerase (PDI) is required for the secretion of a native disulphide-bonded protein from Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Export of a cysteine-free misfolded secretory protein from the endoplasmic reticulum for degradation requires interaction with protein disulfide isomerase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M309673200

Quality control in the secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Secretion efficiency in Saccharomyces cerevisiae of bovine pancreatic trypsin inhibitor mutants lacking disulfide bonds is correlated with thermodynamic stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Protein folding stability can determine the efficiency of escape from endoplasmic reticulum quality control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Accelerated secretion of human lysozyme with a disulfide bond mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Structure of form III crystals of bovine pancreatic trypsin inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

(14-38, 30-51) double-disulphide intermediate in folding of bovine pancreatic trypsin inhibitor: a two-dimensional 1H nuclear magnetic resonance study

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Toward development of a screen to identify randomly encoded, foldable sequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Engineering-enhanced protein secretory expression in yeast with application to insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Multifunctional yeast high-copy-number shuttle vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

KAR2, a karyogamy gene, is the yeast homolog of the mammalian BiP/GRP78 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Saccharomyces cerevisiae CNE1 encodes an endoplasmic reticulum (ER) membrane protein with sequence similarity to calnexin and calreticulin and functions as a constituent of the ER quality control apparatus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Hsp70 molecular chaperone facilitates endoplasmic reticulum-associated protein degradation of cystic fibrosis transmembrane conductance regulator in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

A pathway for targeting soluble misfolded proteins to the yeast vacuole

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Different degradation pathways for heterologous glycoproteins in yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Stress tolerance of misfolded carboxypeptidase Y requires maintenance of protein trafficking and degradative pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Physiological regulation of membrane protein sorting late in the secretory pathway of Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Nascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

A membrane glycoprotein, Sec12p, required for protein transport from the endoplasmic reticulum to the Golgi apparatus in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Distinct retrieval and retention mechanisms are required for the quality control of endoplasmic reticulum protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

ER-golgi traffic is a prerequisite for efficient ER degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

O-mannosylation protects mutant alpha-factor precursor from endoplasmic reticulum-associated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Secretory pathway quality control operating in Golgi, plasmalemmal, and endosomal systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Yeast carboxypeptidase Y vacuolar targeting signal is defined by four propeptide amino acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Behavior in the eukaryotic secretory pathway of insulin-containing fusion proteins and single-chain insulins bearing various B-chain mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Role for the ubiquitin-proteasome system in the vacuolar degradation of Ste6p, the a-factor transporter in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Yeast mutants affecting possible quality control of plasma membrane proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

A mutant plasma membrane ATPase, Pma1-10, is defective in stability at the yeast cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Targeting and assembly of an oligomeric bacterial enterotoxoid in the endoplasmic reticulum of Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

The genetic interaction of kar2 and wbp1 mutations. Distinct functions of binding protein BiP and N-linked glycosylation in the processing pathway of secreted proteins in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

BiP/Kar2p serves as a molecular chaperone during carboxypeptidase Y folding in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Quality Control in the Yeast Secretory Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

The requirement for molecular chaperones during endoplasmic reticulum-associated protein degradation demonstrates that protein export and import are mechanistically distinct

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Role of disulfide bonds in folding and secretion of human lysozyme in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

A kinetic explanation for the rearrangement pathway of BPTI folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Kinetic role of a meta-stable native-like two-disulphide species in the folding transition of bovine pancreatic trypsin inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Reinvestigation of the aromatic side-chains in the basic pancreatic trypsin inhibitor by heteronuclear two-dimensional nuclear magnetic resonance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Amino acid replacement that eliminates kinetic traps in the folding pathway of pancreatic trypsin inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Multicopy overexpression of bovine pancreatic trypsin inhibitor saturates the protein folding and secretory capacity of Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Ligand recognition and domain structure of Vps10p, a vacuolar protein sorting receptor in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Localization of the BiP molecular chaperone with respect to endoplasmic reticulum foci containing the cystic fibrosis transmembrane conductance regulator in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Intracellular retention of newly synthesized insulin in yeast is caused by endoproteolytic processing in the Golgi complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

Degradation of endoplasmic reticulum (ER) quality control substrates requires transport between the ER and Golgi

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309673200

21 January 2018

Identifiers

DOI

10.1074/JBC.M309673200

1 reference

2 September 2017

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