SHP-2 Regulates SOCS-1-mediated Janus Kinase-2 Ubiquitination/Degradation Downstream of the Prolactin Receptor (Q38349714)

2 September 2017

SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/degradation downstream of the prolactin receptor (English)

1 reference

2 September 2017

SHP-2 Regulates SOCS-1-mediated Janus Kinase-2 Ubiquitination/Degradation Downstream of the Prolactin Receptor (English)

1 reference

https://api.crossref.org/works/10.1074/JBC.M306758200

intracellular signaling peptides and proteins

17 March 2024

main subject

protein ubiquitination

1 reference

based on heuristic

inferred from title

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14522994

17 March 2024

proto-oncogene protein

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14522994

17 March 2024

repressor proteins

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14522994

regulation of gene expression

17 March 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14522994

17 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M306758200

17 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M306758200

17 March 2024

author name string

Samir Ali

1

1 reference

2 September 2017

Zaynab Nouhi

2

1 reference

2 September 2017

Naila Chughtai

3

1 reference

2 September 2017

Suhad Ali

4

1 reference

2 September 2017

language of work or name

English

0 references

publication date

1 October 2003

1 reference

2 September 2017

26 December 2003

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14522994

full work available at URL

17 March 2024

http://www.jbc.org/article/S0021925820752026/pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14522994

https://api.elsevier.com/content/article/PII:S0021925820752026?httpAccept=text/xml

17 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M306758200

https://api.elsevier.com/content/article/PII:S0021925820752026?httpAccept=text/plain

17 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M306758200

https://syndication.highwire.org/content/doi/10.1074/jbc.M306758200

17 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M306758200

Journal of Biological Chemistry

17 March 2024

published in

1 reference

2 September 2017

278

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2 September 2017

52

1 reference

2 September 2017

52021-52031

1 reference

Prolactin: the new biology of an old hormone

2 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

A single phosphotyrosine residue of the prolactin receptor is responsible for activation of gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

Linear and cooperative signaling: roles for Stat proteins in the regulation of cell survival and apoptosis in the mammary epithelium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

SHP-2, SH2-containing protein tyrosine phosphatase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

Recruitment of the protein-tyrosine phosphatase SHP-2 to the C-terminal tyrosine of the prolactin receptor and to the adaptor protein Gab2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

A cytosolic protein-tyrosine phosphatase PTP1B specifically dephosphorylates and deactivates prolactin-activated STAT5a and STAT5b

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

PTP1B regulates leptin signal transduction in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

A family of cytokine-inducible inhibitors of signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

A new protein containing an SH2 domain that inhibits JAK kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

Cytokine signaling in 2002: new surprises in the Jak/Stat pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

SOCS-1, -2, -3: selective targets and functions downstream of the prolactin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the beta-casein gene promoter in mammary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

Mathematical models of protein kinase signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306758200

Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response.

21 January 2018

5

1 reference

https://api.crossref.org/works/10.1074/JBC.M306758200

PTP1D is a positive regulator of the prolactin signal leading to beta-casein promoter activation.

17 March 2024

8

1 reference

https://api.crossref.org/works/10.1074/JBC.M306758200

Dominant negative variants of the SHP-2 tyrosine phosphatase inhibit prolactin activation of Jak2 (janus kinase 2) and induction of Stat5 (signal transducer and activator of transcription 5)-dependent transcription

17 March 2024

10

1 reference

https://api.crossref.org/works/10.1074/JBC.M306758200

Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction.

17 March 2024

21

1 reference

https://api.crossref.org/works/10.1074/JBC.M306758200

17 March 2024

Identifiers

1 reference

2 September 2017

1 reference