CYP17 Mutation E305G Causes Isolated 17,20-Lyase Deficiency by Selectively Altering Substrate Binding (Q38350188)

2 September 2017

title

CYP17 mutation E305G causes isolated 17,20-lyase deficiency by selectively altering substrate binding (English)

1 reference

2 September 2017

CYP17 Mutation E305G Causes Isolated 17,20-Lyase Deficiency by Selectively Altering Substrate Binding (English)

1 reference

https://api.crossref.org/works/10.1074/JBC.M307586200

13 March 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14504283

13 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M307586200

13 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M307586200

13 March 2024

author name string

Dov Tiosano

2

1 reference

2 September 2017

Zeev Hochberg

4

1 reference

2 September 2017

Daniel P. Sherbet

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14504283

13 March 2024

Kerri M. Kwist

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14504283

13 March 2024

Richard J. Auchus

5

1 reference

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13 March 2024

language of work or name

English

0 references

publication date

22 September 2003

1 reference

full work available at URL

2 September 2017

http://www.jbc.org/content/278/49/48563.full.pdf

file format

Portable Document Format

online access status

open access

1 reference

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https://api.elsevier.com/content/article/PII:S0021925820756176?httpAccept=text/xml

13 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M307586200

https://api.elsevier.com/content/article/PII:S0021925820756176?httpAccept=text/plain

13 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M307586200

https://syndication.highwire.org/content/doi/10.1074/jbc.M307586200

13 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M307586200

Journal of Biological Chemistry

13 March 2024

published in

1 reference

2 September 2017

volume

278

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2 September 2017

issue

49

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2 September 2017

page(s)

48563-48569

1 reference

Microsomal cytochrome P-450 from neonatal pig testis: two enzymatic activities (17 alpha-hydroxylase and c17,20-lyase) associated with one protein

2 September 2017

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Cytochrome b5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer

21 January 2018

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Modulation of the activity of human 17 alpha-hydroxylase-17,20-lyase (CYP17) by cytochrome b5: endocrinological and mechanistic implications

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The 17, 20-lyase activity of cytochrome p450c17 from human fetal testis favors the delta5 steroidogenic pathway

21 January 2018

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Steroid 17 alpha-hydroxylase and 17,20-lyase activities of P450c17: contributions of serine106 and P450 reductase

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Rat P450(17 alpha) from testis: characterization of a full-length cDNA encoding a unique steroid hydroxylase capable of catalyzing both delta 4- and delta 5-steroid-17,20-lyase reactions

21 January 2018

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Xenopus laevis ovarian CYP17 is a highly potent enzyme expressed exclusively in oocytes. Evidence that oocytes play a critical role in Xenopus ovarian androgen production

21 January 2018

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Molecular cloning and expression of guinea pig cytochrome P450c17 cDNA (steroid 17 alpha-hydroxylase/17,20 lyase): tissue distribution, regulation, and substrate specificity of the expressed enzyme

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17 alpha-hydroxylase/17,20-lyase deficiency: from clinical investigation to molecular definition

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The genetic and functional basis of isolated 17,20-lyase deficiency

21 January 2018

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Differential inhibition of 17alpha-hydroxylase and 17,20-lyase activities by three novel missense CYP17 mutations identified in patients with P450c17 deficiency

21 January 2018

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P450c17 mutations R347H and R358Q selectively disrupt 17,20-lyase activity by disrupting interactions with P450 oxidoreductase and cytochrome b5.

21 January 2018

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Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations.

21 January 2018

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Molecular basis of apparent isolated 17,20-lyase deficiency: compound heterozygous mutations in the C-terminal region (Arg(496)----Cys, Gln(461)----Stop) actually cause combined 17 alpha-hydroxylase/17,20-lyase deficiency

21 January 2018

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Pitfalls in characterizing P450c17 mutations associated with isolated 17,20-lyase deficiency

21 January 2018

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Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues

21 January 2018

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The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21.

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A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains

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Molecular evolution of adrenarche: structural and functional analysis of p450c17 from four primate species

21 January 2018

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Total biosynthesis of hydrocortisone from a simple carbon source in yeast

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21 January 2018

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An analysis of the role of active site protic residues of cytochrome P-450s: mechanistic and mutational studies on 17alpha-hydroxylase-17,20-lyase (P-45017alpha also CYP17).

21 January 2018

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Uncoupling of the cytochrome P-450cam monooxygenase reaction by a single mutation, threonine-252 to alanine or valine: possible role of the hydroxy amino acid in oxygen activation

21 January 2018

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21 January 2018

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Molecular cloning of an allene oxide synthase: a cytochrome P450 specialized for the metabolism of fatty acid hydroperoxides

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Evidence that androgens are the primary steroids produced by Xenopus laevis ovaries and may signal through the classical androgen receptor to promote oocyte maturation

21 January 2018

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Cytochrome b5 stimulates purified testicular microsomal cytochrome P-450 (C21 side-chain cleavage)

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21 January 2018

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21 January 2018

17

81

3797

Miura

1996

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The Journal of Clinical Endocrinology and Metabolism

13 March 2024

25

author name string

Costa-Santos

publication date

2003

1 reference

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Yeast expression of animal and plant P450s in optimized redox environments

13 March 2024

26

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Sequence alignments, variabilities, and vagaries.

13 March 2024

33

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13 March 2024

Identifiers

1 reference

release_jvaz6sw6ejahxfdt4663a577j4

2 September 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/jvaz6sw6ejahxfdt4663a577j4

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference