The single-stranded DNA end binding site of p53 coincides with the C-terminal regulatory region. (Q38353041)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8836183%20AND%20SRC:MED&resulttype=core&format=json

19 October 2019

title

The single-stranded DNA end binding site of p53 coincides with the C-terminal regulatory region (English)

1 reference

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19 October 2019

1

1 reference

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19 October 2019

Georgy Bakalkin

5

1 reference

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19 October 2019

Klas Wiman

7

1 reference

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19 October 2019

author name string

V Iotsova

2

1 reference

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19 October 2019

E Kiseleva

3

1 reference

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19 October 2019

M Ström

4

1 reference

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19 October 2019

R C Grafström

6

1 reference

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19 October 2019

language of work or name

English

0 references

publication date

1 September 1996

1 reference

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19 October 2019

number of pages

8

1 reference

based on heuristic

inferred from page(s)

published in

Nucleic Acids Research

1 reference

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19 October 2019

volume

24

1 reference

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19 October 2019

issue

18

1 reference

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19 October 2019

page(s)

3560-3567

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8836183%20AND%20SRC:MED&resulttype=core&format=json

Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus

19 October 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

mdm2 expression is induced by wild type p53 activity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

The p53-mdm-2 autoregulatory feedback loop

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

WAF1, a potential mediator of p53 tumor suppression

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Human p53 directs DNA strand reassociation and is photolabelled by 8-azido ATP

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Cyclin G is a transcriptional target of the p53 tumor suppressor protein

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Allosteric activation of latent p53 tetramers

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

p53 oligomerization and DNA looping are linked with transcriptional activation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

[Leu5]enkephalin-encoding sequences are targets for a specific DNA-binding factor

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Mutations in p53 as potential molecular markers for human breast cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Participation of p53 protein in the cellular response to DNA damage

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

A DNA binding domain is contained in the C-terminus of wild type p53 protein

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Oncogenic forms of p53 inhibit p53-regulated gene expression

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

p53 function and dysfunction

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Regulation of the specific DNA binding function of p53

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Wild-type p53 is a cell cycle checkpoint determinant following irradiation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Definition of a consensus binding site for p53

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

p53: a cell cycle regulator activated by DNA damage

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

p53: at the crossroads of molecular carcinogenesis and risk assessment

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Presence of a potent transcription activating sequence in the p53 protein

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

A C-terminal alpha-helix plus basic region motif is the major structural determinant of p53 tetramerization

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Thymocyte apoptosis induced by p53-dependent and independent pathways.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

p53 domains: identification and characterization of two autonomous DNA-binding regions.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Small peptides activate the latent sequence-specific DNA binding function of p53.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

Different forms of p53 detected by monoclonal antibodies in non-dividing and dividing lymphocytes

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146129

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

31 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/8836183

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

High levels of p53 protein in UV-irradiated normal human skin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/8836183

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/24.18.3560

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8836183%20AND%20SRC:MED&resulttype=core&format=json

19 October 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8836183%20AND%20SRC:MED&resulttype=core&format=json

19 October 2019

PubMed publication ID

8836183

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8836183%20AND%20SRC:MED&resulttype=core&format=json