Therapeutic applications of ghrelin agonists in the treatment of gastroparesis (Q38363587)

2 September 2017

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title

Therapeutic applications of ghrelin agonists in the treatment of gastroparesis (English)

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2 September 2017

1

Andrea Shin

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2 September 2017

John M Wo

2

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2 September 2017

1 February 2015

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Current gastroenterology reports

2 September 2017

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2 September 2017

17

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2 September 2017

430

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2 September 2017

2

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https://scigraph.springernature.com/pub.10.1007/s11894-015-0430-8

2 September 2017

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cites work

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Demography, clinical characteristics, psychological and abuse profiles, treatment, and long-term follow-up of patients with gastroparesis.

21 January 2018

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Loss of interstitial cells of cajal and inhibitory innervation in insulin-dependent diabetes

21 January 2018

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Insulin restores neuronal nitric oxide synthase expression and function that is lost in diabetic gastropathy.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Metoclopramide: pharmacology and clinical application

21 January 2018

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Review article: metoclopramide and tardive dyskinesia

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Recent advances in the pathophysiology and treatment of gastroparesis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Actions and therapeutic pathways of ghrelin for gastrointestinal disorders

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Ghrelin signaling in the gut, its physiological properties, and therapeutic potential

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Genomic structure and characterization of the 5'-flanking region of the human ghrelin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

21 January 2018

Ghrelin gets its GOAT.

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Comparison of vasodilators in human internal mammary artery: ghrelin is a potent physiological antagonist of endothelin-1.

21 January 2018

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Ghrelin stimulates proliferation and differentiation and inhibits apoptosis in osteoblastic MC3T3-E1 cells

21 January 2018

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Ghrelin action in the brain controls adipocyte metabolism

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

A role for ghrelin in the central regulation of feeding

21 January 2018

1 reference

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Ghrelin modulates brain activity in areas that control appetitive behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Antagonism of ghrelin receptor reduces food intake and body weight gain in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Targeting the ghrelin receptor to regulate food intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Effects by daily long term provision of ghrelin to unselected weight-losing cancer patients: a randomized double-blind study.

21 January 2018

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Endogenous production of ghrelin and beneficial effects of its exogenous administration in monocrotaline-induced pulmonary hypertension.

21 January 2018

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Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Growth hormone secretagogue receptors in rat and human gastrointestinal tract and the effects of ghrelin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Evidence for the presence of motilin, ghrelin, and the motilin and ghrelin receptor in neurons of the myenteric plexus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

The prokinetic-like activity of ghrelin in rat isolated stomach is mediated via cholinergic and tachykininergic motor neurones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Gastric motor effects of peptide and non-peptide ghrelin agonists in mice in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Gastric motor effects of ghrelin and growth hormone releasing peptide 6 in diabetic mice with gastroparesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Administration of exogenous acylated ghrelin or rikkunshito, an endogenous ghrelin enhancer, improves the decrease in postprandial gastric motility in an acute restraint stress mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

The role of the vagus nerve in the migrating motor complex and ghrelin- and motilin-induced gastric contraction in suncus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

New method of manometric measurement of gastroduodenal motility in conscious mice: effects of ghrelin and Y2 depletion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Ghrelin regulates gastric phase III-like contractions in freely moving conscious mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Potentiation of ghrelin signaling attenuates cancer anorexia-cachexia and prolongs survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Molecular identification of ghrelin receptor (GHS-R1a) and its functional role in the gastrointestinal tract of the guinea-pig

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Prokineticin-2, motilin, ghrelin and metoclopramide: prokinetic utility in mouse stomach and colon

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Ghrelin does not stimulate gastrointestinal motility and gastric emptying: an experimental study of conscious dogs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Contrasting effects of ghrelin and des-acyl ghrelin on the lumbo-sacral defecation center and regulation of colorectal motility in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Ghrelin-induced stimulation of colonic propulsion is dependent on hypothalamic neuropeptide Y1- and corticotrophin-releasing factor 1 receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Central neuropeptide Y receptors are involved in 3rd ventricular ghrelin induced alteration of colonic transit time in conscious fed rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Influence of ghrelin on interdigestive gastrointestinal motility in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Influence of ghrelin on the gastric accommodation reflex and on meal-induced satiety in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Obesity does not increase effects of synthetic ghrelin on human gastric motor functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Ghrelin stimulates gastric emptying and hunger in normal-weight humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Abnormal ghrelin and pancreatic polypeptide responses in gastroparesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled, crossover study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Influence of ghrelin on gastric emptying and meal-related symptoms in idiopathic gastroparesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Ghrelin gastrokinetic action in patients with neurogenic gastroparesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Constant intravenous ghrelin infusion in healthy young men: clinical pharmacokinetics and metabolic effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Pharmacological demarcation of the growth hormone, gut motility and feeding effects of ghrelin using a novel ghrelin receptor agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Ghrelin receptor agonist (TZP-101) accelerates gastric emptying in adults with diabetes and symptomatic gastroparesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Randomised clinical trial: ghrelin agonist TZP-101 relieves gastroparesis associated with severe nausea and vomiting--randomised clinical study subset data.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Randomized controlled phase Ib study of ghrelin agonist, RM-131, in type 2 diabetic women with delayed gastric emptying: pharmacokinetics and pharmacodynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

A ghrelin agonist fails to show benefit in patients with diabetic gastroparesis: let's not throw the baby out with the bath water.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

The ghrelin agonist RM-131 accelerates gastric emptying of solids and reduces symptoms in patients with type 1 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Ghrelin and motilin receptor agonists: time to introduce bias into drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Development and content validity of a gastroparesis cardinal symptom index daily diary.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Can symptoms discriminate among those with delayed or normal gastric emptying in dysmotility-like dyspepsia?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Anti-emetic activity of ghrelin in ferrets exposed to the cytotoxic anti-cancer agent cisplatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Elevated serum ghrelin levels in adult patients with cyclic vomiting syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Ghrelin and motilin levels in hyperemesis gravidarum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Effects of ghrelin administration during chemotherapy with advanced esophageal cancer patients: a prospective, randomized, placebo-controlled phase 2 study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Effects of acute administration of acylated and unacylated ghrelin on glucose and insulin concentrations in morbidly obese subjects without overt diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11894-015-0430-8

Clinical response and side effects of metoclopramide: associations with clinical, demographic, and pharmacogenetic parameters

21 January 2018

1 reference

12 December 2020

Cellular changes in diabetic and idiopathic gastroparesis

1 reference

12 December 2020

Hemodynamic and hormonal effects of human ghrelin in healthy volunteers

1 reference

12 December 2020

Heme oxygenase-1 protects interstitial cells of Cajal from oxidative stress and reverses diabetic gastroparesis.

1 reference

12 December 2020

Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat

1 reference

12 December 2020

Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans

1 reference

12 December 2020

Endogenous and exogenous ghrelin enhance the colonic and gastric manifestations of dextran sodium sulphate-induced colitis in mice

1 reference

12 December 2020

Hormones regulating lipid metabolism and plasma lipids in childhood obesity

1 reference

12 December 2020

Identification of genes for the ghrelin and motilin receptors and a novel related gene in fish, and stimulation of intestinal motility in zebrafish (Danio rerio) by ghrelin and motilin

1 reference

12 December 2020

Hyperglycaemia slows gastric emptying in type 1 (insulin-dependent) diabetes mellitus

1 reference

12 December 2020

Safety and efficacy of ghrelin agonist TZP-101 in relieving symptoms in patients with diabetic gastroparesis: a randomized, placebo-controlled study

1 reference

12 December 2020

Endogenous acyl ghrelin is involved in mediating spontaneous phase III-like contractions of the rat stomach

1 reference

12 December 2020

CD206-positive M2 macrophages that express heme oxygenase-1 protect against diabetic gastroparesis in mice

1 reference

12 December 2020

Myenteric plexus of obese diabetic mice (an animal model of human type 2 diabetes).

1 reference

12 December 2020

Contractile effects of ghrelin-related peptides on the chicken gastrointestinal tract in vitro

1 reference

12 December 2020

Ileocolonic transfer of solid chyme in small intestinal neuropathies and myopathies

1 reference

12 December 2020

Preclinical gastrointestinal prokinetic efficacy and endocrine effects of the ghrelin mimetic RM-131

1 reference

12 December 2020

10.1007/S11894-015-0430-8

Identifiers

DOI

1 reference

PubMed ID

25702264

Dimensions Publication ID

2 September 2017

0 references

1 reference

PubMed ID

25702264