Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates. (Q38368814)

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26 March 2020

title

Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates (English)

1 reference

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RNA recognition motif domain

26 March 2020

main subject

1 reference

5

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26 March 2020

author name string

Cyrille Garnier

1

1 reference

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26 March 2020

François Devred

2

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26 March 2020

Deborah Byrne

3

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26 March 2020

Rémy Puppo

4

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26 March 2020

Soazig Malesinski

6

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26 March 2020

Andrey V Golovin

7

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26 March 2020

Régine Lebrun

8

1 reference

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26 March 2020

Natalia N Ninkina

9

1 reference

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26 March 2020

Philipp O Tsvetkov

10

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26 March 2020

language of work or name

English

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publication date

28 July 2017

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26 March 2020

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26 March 2020

volume

7

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issue

1

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26 March 2020

page(s)

6812

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Creative Commons Attribution 4.0 International

26 March 2020

copyright license

start time

28 July 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/s41598-017-07215-7

0 references

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Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation and inclusion formation

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Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients.

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Folding of the RNA recognition motif (RRM) domains of the amyotrophic lateral sclerosis (ALS)-linked protein TDP-43 reveals an intermediate state

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"Structural characterization of the minimal segment of TDP-43 competent for aggregation".

6 September 2017

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The role of TDP-43 in the pathogenesis of ALS and FTLD.

6 September 2017

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Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43

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The truncated C-terminal RNA recognition motif of TDP-43 protein plays a key role in forming proteinaceous aggregates

6 September 2017

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TDP-43 skeins show properties of amyloid in a subset of ALS cases

6 September 2017

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TDP-43 aggregation in neurodegeneration: are stress granules the key?

6 September 2017

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6 September 2017

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TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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A comparative study of the relationship between protein structure and beta-aggregation in globular and intrinsically disordered proteins.

6 September 2017

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Cation binding mode of fully oxidised calmodulin explained by the unfolding of the apostate.

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Zinc induces depletion and aggregation of endogenous TDP-43.

6 September 2017

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Inclusions in frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP) and amyotrophic lateral sclerosis (ALS), but not FTLD with FUS proteinopathy (FTLD-FUS), have properties of amyloid.

14 September 2017

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An Amyloid-Like Pathological Conformation of TDP-43 Is Stabilized by Hypercooperative Hydrogen Bonds

27 September 2017

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TDP-43 pathology in Alzheimer's disease, dementia with Lewy bodies and ageing.

23 June 2018

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TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domain

23 June 2018

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Minimal Zn(2+) binding site of amyloid-β.

23 June 2018

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The English (H6R) familial Alzheimer's disease mutation facilitates zinc-induced dimerization of the amyloid-β metal-binding domain.

23 June 2018

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31 August 2018

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31 August 2018

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Zinc-induced dimerization of the amyloid-β metal-binding domain 1-16 is mediated by residues 11-14.

31 August 2018

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Isomerization of the Asp7 residue results in zinc-induced oligomerization of Alzheimer's disease amyloid beta(1-16) peptide

31 August 2018

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A simple algorithm locates beta-strands in the amyloid fibril core of alpha-synuclein, Abeta, and tau using the amino acid sequence alone

31 August 2018

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Recoverin is a zinc-binding protein.

31 August 2018

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Zinc-induced decrease of the thermal stability and regeneration of rhodopsin.

31 August 2018

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The Role of TDP-43 in Alzheimer's Disease

31 August 2018

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Crossref

https://api.crossref.org/works/10.1038%2FS41598-017-07215-7

Peripherally Applied Synthetic Tetrapeptides HAEE and RADD Slow Down the Development of Cerebral β-Amyloidosis in AβPP/PS1 Transgenic Mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FS41598-017-07215-7

New insights into tau-microtubules interaction revealed by isothermal titration calorimetry

21 January 2018

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inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1038/S41598-017-07215-7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28754988%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

26 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28754988%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

PubMed publication ID

28754988

1 reference