Biosynthetically engineered lipopolysaccharide as vaccine adjuvant (Q38386726)

2 September 2017

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title

Biosynthetically engineered lipopolysaccharide as vaccine adjuvant (English)

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2 September 2017

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2

Peter van der Ley

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author name string

Afshin Zariri

series ordinal

1

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2 September 2017

Peter van der Ley

series ordinal

2

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2 September 2017

publication date

22 March 2015

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Expert Review of Vaccines

2 September 2017

published in

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2 September 2017

volume

14

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2 September 2017

issue

6

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2 September 2017

page(s)

861-876

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Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants

2 September 2017

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Lipopolysaccharide engineering in Neisseria meningitidis: structural analysis of different pentaacyl lipid A mutants and comparison of their modified agonist properties

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Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

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Recognition of lipid A variants by the TLR4-MD-2 receptor complex

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21 January 2018

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Salmonella enterica serovar Typhimurium lipopolysaccharide deacylation enhances its intracellular growth within macrophages

21 January 2018

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Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response

21 January 2018

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The Pseudomonas aeruginosa lipid A deacylase: selection for expression and loss within the cystic fibrosis airway.

21 January 2018

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Unique lipid a modifications in Pseudomonas aeruginosa isolated from the airways of patients with cystic fibrosis.

21 January 2018

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Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa

21 January 2018

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Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses.

21 January 2018

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Attenuated virulence of a Francisella mutant lacking the lipid A 4'-phosphatase

21 January 2018

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Naturally occurring lipid A mutants in neisseria meningitidis from patients with invasive meningococcal disease are associated with reduced coagulopathy

21 January 2018

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The structure of Neisseria meningitidis lipid A determines outcome in experimental meningococcal disease

21 January 2018

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Hexa-acylated lipid A is required for host inflammatory response to Neisseria gonorrhoeae in experimental gonorrhea

21 January 2018

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The transcriptional repressor FarR is not involved in meningococcal fatty acid resistance mediated by the FarAB efflux pump and dependent on lipopolysaccharide structure

21 January 2018

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Absence of PmrAB-mediated phosphoethanolamine modifications of Citrobacter rodentium lipopolysaccharide affects outer membrane integrity

21 January 2018

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21 January 2018

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21 January 2018

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Phosphoethanolamine residues on the lipid A moiety of Neisseria gonorrhoeae lipooligosaccharide modulate binding of complement inhibitors and resistance to complement killing

21 January 2018

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Lipid A's structure mediates Neisseria gonorrhoeae fitness during experimental infection of mice and men.

21 January 2018

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Enzymatic modification of lipid A by ArnT protects Bordetella bronchiseptica against cationic peptides and is required for transmission.

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21 January 2018

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A live attenuated strain of Yersinia pestis KIM as a vaccine against plague

21 January 2018

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D27-pLpxL, an avirulent strain of Yersinia pestis, primes T cells that protect against pneumonic plague

21 January 2018

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A Yersinia pestis lpxM-mutant live vaccine induces enhanced immunity against bubonic plague in mice and guinea pigs.

21 January 2018

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Pleiotropic effects of the lpxM mutation in Yersinia pestis resulting in modification of the biosynthesis of major immunoreactive antigens.

21 January 2018

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Live, attenuated strains of Listeria and Salmonella as vaccine vectors in cancer treatment

21 January 2018

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New technologies in developing recombinant attenuated Salmonella vaccine vectors

21 January 2018

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Effect of deletion of genes involved in lipopolysaccharide core and O-antigen synthesis on virulence and immunogenicity of Salmonella enterica serovar typhimurium

21 January 2018

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Regulated delayed expression of rfaH in an attenuated Salmonella enterica serovar typhimurium vaccine enhances immunogenicity of outer membrane proteins and a heterologous antigen

21 January 2018

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Lipid A mutant Salmonella with suppressed virulence and TNFalpha induction retain tumor-targeting in vivo

21 January 2018

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Palmitoylation state impacts induction of innate and acquired immunity by the Salmonella enterica serovar typhimurium msbB mutant

21 January 2018

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Expression of the lipopolysaccharide-modifying enzymes PagP and PagL modulates the endotoxic activity of Bordetella pertussis

21 January 2018

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Identification of a novel lipopolysaccharide core biosynthesis gene cluster in Bordetella pertussis, and influence of core structure and lipid A glucosamine substitution on endotoxic activity

21 January 2018

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Substitution of the Bordetella pertussis lipid A phosphate groups with glucosamine is required for robust NF-kappaB activation and release of proinflammatory cytokines in cells expressing human but not murine Toll-like receptor 4-MD-2-CD14

21 January 2018

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Outer membrane vesicles reflect environmental cues in Gallibacterium anatis.

21 January 2018

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Biological functions and biogenesis of secreted bacterial outer membrane vesicles

21 January 2018

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Quantitative proteomics reveals distinct differences in the protein content of outer membrane vesicle vaccines.

21 January 2018

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Improved production process for native outer membrane vesicle vaccine against Neisseria meningitidis

21 January 2018

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Meningococcal outer membrane vesicle vaccines derived from mutant strains engineered to express factor H binding proteins from antigenic variant groups 1 and 2

21 January 2018

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Bactericidal antibody responses elicited by a meningococcal outer membrane vesicle vaccine with overexpressed factor H-binding protein and genetically attenuated endotoxin

21 January 2018

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A phase 1 study of a meningococcal native outer membrane vesicle vaccine made from a group B strain with deleted lpxL1 and synX, over-expressed factor H binding protein, two PorAs and stabilized OpcA expression.

21 January 2018

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Lipopolysaccharide modifications of a cholera vaccine candidate based on outer membrane vesicles reduce endotoxicity and reveal the major protective antigen.

21 January 2018

1 reference

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Modulation of endotoxicity of Shigella generalized modules for membrane antigens (GMMA) by genetic lipid A modifications: relative activation of TLR4 and TLR2 pathways in different mutants

21 January 2018

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LOS oligosaccharide modification enhances dendritic cell responses to meningococcal native outer membrane vesicles expressing a non-toxic lipid A

21 January 2018

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Neisseria meningitidis native outer membrane vesicles containing different lipopolysaccharide glycoforms as adjuvants for meningococcal and nonmeningococcal antigens

21 January 2018

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Adjuvant effect of bacterial outer membrane vesicles with penta-acylated lipopolysaccharide on antigen-specific T cell priming

21 January 2018

1 reference

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Delivery of foreign antigens by engineered outer membrane vesicle vaccines

21 January 2018

1 reference

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Structural modifications of outer membrane vesicles to refine them as vaccine delivery vehicles

21 January 2018

1 reference

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Immunization with Salmonella enterica serovar Typhimurium-derived outer membrane vesicles delivering the pneumococcal protein PspA confers protection against challenge with Streptococcus pneumoniae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Innate immune responses of synthetic lipid A derivatives of Neisseria meningitidis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

The structurally similar, penta-acylated lipopolysaccharides of Porphyromonas gingivalis and Bacteroides elicit strikingly different innate immune responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Expression of a Porphyromonas gingivalis lipid A palmitylacyltransferase in Escherichia coli yields a chimeric lipid A with altered ability to stimulate interleukin-8 secretion

21 January 2018

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Expression of foreign LpxA acyltransferases in Neisseria meningitidis results in modified lipid A with reduced toxicity and retained adjuvant activity

21 January 2018

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Differential induction of the toll-like receptor 4-MyD88-dependent and -independent signaling pathways by endotoxins

21 January 2018

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The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4.

21 January 2018

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TRIF is required for TLR4 mediated adjuvant effects on T cell clonal expansion

21 January 2018

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Adjuvant activity of naturally occurring monophosphoryl lipopolysaccharide preparations from mucosa-associated bacteria

21 January 2018

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Differential activation of human and mouse Toll-like receptor 4 by the adjuvant candidate LpxL1 of Neisseria meningitidis

21 January 2018

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MsbA transporter-dependent lipid A 1-dephosphorylation on the periplasmic surface of the inner membrane: topography of francisella novicida LpxE expressed in Escherichia coli

21 January 2018

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Construction of an Escherichia coli mutant producing monophosphoryl lipid A.

21 January 2018

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Construction of monophosphoryl lipid A producing Escherichia coli mutants and comparison of immuno-stimulatory activities of their lipopolysaccharides

21 January 2018

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https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

The polysaccharide portion plays an indispensable role in Salmonella lipopolysaccharide-induced activation of NF-kappaB through human toll-like receptor 4.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Neisseria meningitidis lipooligosaccharide structure-dependent activation of the macrophage CD14/Toll-like receptor 4 pathway

21 January 2018

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The lipopolysaccharide from Capnocytophaga canimorsus reveals an unexpected role of the core-oligosaccharide in MD-2 binding

21 January 2018

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Helicobacter pylori modulates the T helper cell 1/T helper cell 2 balance through phase-variable interaction between lipopolysaccharide and DC-SIGN.

21 January 2018

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Variation of Neisseria gonorrhoeae lipooligosaccharide directs dendritic cell-induced T helper responses

21 January 2018

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Role of N-acetylglucosamine within core lipopolysaccharide of several species of gram-negative bacteria in targeting the DC-SIGN (CD209).

21 January 2018

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Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR.

21 January 2018

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BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module

21 January 2018

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https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria

21 January 2018

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Coincorporation of LpxL1 and PagL mutant lipopolysaccharides into liposomes with Neisseria meningitidis opacity protein: influence on endotoxic and adjuvant activity

21 January 2018

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https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Intracellular delivery of lipopolysaccharide induces effective Th1-immune responses independent of IL-12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Humanized TLR4/MD-2 mice reveal LPS recognition differentially impacts susceptibility to Yersinia pestis and Salmonella enterica

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Noncanonical inflammasome activation by intracellular LPS independent of TLR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Meningitis bacterium is viable without endotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

10.1586/14760584.2015.1026808

21 January 2018

Identifiers

DOI

1 reference

2 September 2017

1 reference