Biosynthetically engineered lipopolysaccharide as vaccine adjuvant (Q38386726)

2 September 2017

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title

Biosynthetically engineered lipopolysaccharide as vaccine adjuvant (English)

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2 September 2017

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2

Peter van der Ley

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author name string

Afshin Zariri

series ordinal

1

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PubMed ID

25797360

2 September 2017

Peter van der Ley

series ordinal

2

1 reference

2 September 2017

22 March 2015

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Expert Review of Vaccines

2 September 2017

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2 September 2017

14

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2 September 2017

6

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2 September 2017

861-876

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Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants

2 September 2017

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Innate immune recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Understanding how lipopolysaccharide impacts CD4 T-cell immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Lipopolysaccharide endotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

The chemical structure of bacterial endotoxin in relation to bioactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Structural requirements of lipid A for endotoxicity and other biological activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Lipid A modification systems in gram-negative bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Lipopolysaccharide analogs improve efficacy of acellular pertussis vaccine and reduce type I hypersensitivity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Salmonella synthesizing 1-dephosphorylated [corrected] lipopolysaccharide exhibits low endotoxic activity while retaining its immunogenicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Modulating the innate immune response by combinatorial engineering of endotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Putting endotoxin to work for us: monophosphoryl lipid A as a safe and effective vaccine adjuvant

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Recent clinical experience with vaccines using MPL- and QS-21-containing adjuvant systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Structure of bacterial lipopolysaccharides

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Structural and functional analyses of bacterial lipopolysaccharides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Toll-like receptors and their crosstalk with other innate receptors in infection and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Pathway for lipid A biosynthesis in Arabidopsis thaliana resembling that of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Novel Type of Endotoxin Structure Present in Bordetella pertussis. Isolation of Two Different Polysaccharides Bound to Lipid A

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Modification of lipid A biosynthesis in Neisseria meningitidis lpxL mutants: influence on lipopolysaccharide structure, toxicity, and adjuvant activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Accumulation of the lipid A precursor UDP-2,3-diacylglucosamine in an Escherichia coli mutant lacking the lpxH gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Moraxella catarrhalis bacterium without endotoxin, a potential vaccine candidate

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Meningitis caused by a lipopolysaccharide deficient Neisseria meningitidis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Lipopolysaccharide engineering in Neisseria meningitidis: structural analysis of different pentaacyl lipid A mutants and comparison of their modified agonist properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Recognition of lipid A variants by the TLR4-MD-2 receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Fortifying the barrier: the impact of lipid A remodelling on bacterial pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Salmonella enterica serovar Typhimurium lipopolysaccharide deacylation enhances its intracellular growth within macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

The Pseudomonas aeruginosa lipid A deacylase: selection for expression and loss within the cystic fibrosis airway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Unique lipid a modifications in Pseudomonas aeruginosa isolated from the airways of patients with cystic fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Attenuated virulence of a Francisella mutant lacking the lipid A 4'-phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Naturally occurring lipid A mutants in neisseria meningitidis from patients with invasive meningococcal disease are associated with reduced coagulopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

The structure of Neisseria meningitidis lipid A determines outcome in experimental meningococcal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Hexa-acylated lipid A is required for host inflammatory response to Neisseria gonorrhoeae in experimental gonorrhea

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

The transcriptional repressor FarR is not involved in meningococcal fatty acid resistance mediated by the FarAB efflux pump and dependent on lipopolysaccharide structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Absence of PmrAB-mediated phosphoethanolamine modifications of Citrobacter rodentium lipopolysaccharide affects outer membrane integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Lack of lipid A pyrophosphorylation and functional lptA reduces inflammation by Neisseria commensals

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Modification of lipooligosaccharide with phosphoethanolamine by LptA in Neisseria meningitidis enhances meningococcal adhesion to human endothelial and epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Phosphoethanolamine residues on the lipid A moiety of Neisseria gonorrhoeae lipooligosaccharide modulate binding of complement inhibitors and resistance to complement killing

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Lipid A's structure mediates Neisseria gonorrhoeae fitness during experimental infection of mice and men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Enzymatic modification of lipid A by ArnT protects Bordetella bronchiseptica against cationic peptides and is required for transmission.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Biological cost of different mechanisms of colistin resistance and their impact on virulence in Acinetobacter baumannii.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Live attenuated tularemia vaccines: recent developments and future goals

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Live-attenuated Yersinia pestis vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Temperature-dependent variations and intraspecies diversity of the structure of the lipopolysaccharide of Yersinia pestis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

A live attenuated strain of Yersinia pestis KIM as a vaccine against plague

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

D27-pLpxL, an avirulent strain of Yersinia pestis, primes T cells that protect against pneumonic plague

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

A Yersinia pestis lpxM-mutant live vaccine induces enhanced immunity against bubonic plague in mice and guinea pigs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Pleiotropic effects of the lpxM mutation in Yersinia pestis resulting in modification of the biosynthesis of major immunoreactive antigens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Live, attenuated strains of Listeria and Salmonella as vaccine vectors in cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

New technologies in developing recombinant attenuated Salmonella vaccine vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Effect of deletion of genes involved in lipopolysaccharide core and O-antigen synthesis on virulence and immunogenicity of Salmonella enterica serovar typhimurium

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Regulated delayed expression of rfaH in an attenuated Salmonella enterica serovar typhimurium vaccine enhances immunogenicity of outer membrane proteins and a heterologous antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Lipid A mutant Salmonella with suppressed virulence and TNFalpha induction retain tumor-targeting in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Palmitoylation state impacts induction of innate and acquired immunity by the Salmonella enterica serovar typhimurium msbB mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Expression of the lipopolysaccharide-modifying enzymes PagP and PagL modulates the endotoxic activity of Bordetella pertussis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Identification of a novel lipopolysaccharide core biosynthesis gene cluster in Bordetella pertussis, and influence of core structure and lipid A glucosamine substitution on endotoxic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Substitution of the Bordetella pertussis lipid A phosphate groups with glucosamine is required for robust NF-kappaB activation and release of proinflammatory cytokines in cells expressing human but not murine Toll-like receptor 4-MD-2-CD14

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Outer membrane vesicles reflect environmental cues in Gallibacterium anatis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Biological functions and biogenesis of secreted bacterial outer membrane vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Quantitative proteomics reveals distinct differences in the protein content of outer membrane vesicle vaccines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Improved production process for native outer membrane vesicle vaccine against Neisseria meningitidis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Meningococcal outer membrane vesicle vaccines derived from mutant strains engineered to express factor H binding proteins from antigenic variant groups 1 and 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Bactericidal antibody responses elicited by a meningococcal outer membrane vesicle vaccine with overexpressed factor H-binding protein and genetically attenuated endotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

A phase 1 study of a meningococcal native outer membrane vesicle vaccine made from a group B strain with deleted lpxL1 and synX, over-expressed factor H binding protein, two PorAs and stabilized OpcA expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Lipopolysaccharide modifications of a cholera vaccine candidate based on outer membrane vesicles reduce endotoxicity and reveal the major protective antigen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Modulation of endotoxicity of Shigella generalized modules for membrane antigens (GMMA) by genetic lipid A modifications: relative activation of TLR4 and TLR2 pathways in different mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

LOS oligosaccharide modification enhances dendritic cell responses to meningococcal native outer membrane vesicles expressing a non-toxic lipid A

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Neisseria meningitidis native outer membrane vesicles containing different lipopolysaccharide glycoforms as adjuvants for meningococcal and nonmeningococcal antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Adjuvant effect of bacterial outer membrane vesicles with penta-acylated lipopolysaccharide on antigen-specific T cell priming

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Delivery of foreign antigens by engineered outer membrane vesicle vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Structural modifications of outer membrane vesicles to refine them as vaccine delivery vehicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Immunization with Salmonella enterica serovar Typhimurium-derived outer membrane vesicles delivering the pneumococcal protein PspA confers protection against challenge with Streptococcus pneumoniae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Innate immune responses of synthetic lipid A derivatives of Neisseria meningitidis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

The structurally similar, penta-acylated lipopolysaccharides of Porphyromonas gingivalis and Bacteroides elicit strikingly different innate immune responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Expression of a Porphyromonas gingivalis lipid A palmitylacyltransferase in Escherichia coli yields a chimeric lipid A with altered ability to stimulate interleukin-8 secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Expression of foreign LpxA acyltransferases in Neisseria meningitidis results in modified lipid A with reduced toxicity and retained adjuvant activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Differential induction of the toll-like receptor 4-MyD88-dependent and -independent signaling pathways by endotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

TRIF is required for TLR4 mediated adjuvant effects on T cell clonal expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Adjuvant activity of naturally occurring monophosphoryl lipopolysaccharide preparations from mucosa-associated bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Differential activation of human and mouse Toll-like receptor 4 by the adjuvant candidate LpxL1 of Neisseria meningitidis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

MsbA transporter-dependent lipid A 1-dephosphorylation on the periplasmic surface of the inner membrane: topography of francisella novicida LpxE expressed in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Construction of an Escherichia coli mutant producing monophosphoryl lipid A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Construction of monophosphoryl lipid A producing Escherichia coli mutants and comparison of immuno-stimulatory activities of their lipopolysaccharides

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

The polysaccharide portion plays an indispensable role in Salmonella lipopolysaccharide-induced activation of NF-kappaB through human toll-like receptor 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Neisseria meningitidis lipooligosaccharide structure-dependent activation of the macrophage CD14/Toll-like receptor 4 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

The lipopolysaccharide from Capnocytophaga canimorsus reveals an unexpected role of the core-oligosaccharide in MD-2 binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Helicobacter pylori modulates the T helper cell 1/T helper cell 2 balance through phase-variable interaction between lipopolysaccharide and DC-SIGN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Variation of Neisseria gonorrhoeae lipooligosaccharide directs dendritic cell-induced T helper responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Role of N-acetylglucosamine within core lipopolysaccharide of several species of gram-negative bacteria in targeting the DC-SIGN (CD209).

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Coincorporation of LpxL1 and PagL mutant lipopolysaccharides into liposomes with Neisseria meningitidis opacity protein: influence on endotoxic and adjuvant activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Intracellular delivery of lipopolysaccharide induces effective Th1-immune responses independent of IL-12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Humanized TLR4/MD-2 mice reveal LPS recognition differentially impacts susceptibility to Yersinia pestis and Salmonella enterica

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Noncanonical inflammasome activation by intracellular LPS independent of TLR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

Meningitis bacterium is viable without endotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.1026808

10.1586/14760584.2015.1026808

21 January 2018

Identifiers

DOI

1 reference

2 September 2017

1 reference

PubMed ID

25797360