Updates on artemisinin: an insight to mode of actions and strategies for enhanced global production (Q38392573)

2 September 2017

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title

Updates on artemisinin: an insight to mode of actions and strategies for enhanced global production (English)

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2 September 2017

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Neha Pandey

1

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2 September 2017

Shashi Pandey-Rai

series ordinal

2

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2 September 2017

language of work or name

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27 March 2015

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2 September 2017

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2 September 2017

volume

253

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2 September 2017

issue

1

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2 September 2017

page(s)

15-30

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Targeting the TGFβ signalling pathway in disease

2 September 2017

cites work

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https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Over-expression of HMG-CoA reductase and amorpha-4,11-diene synthase genes in Artemisia annua L. and its influence on artemisinin content

21 January 2018

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Overexpression of the HMG-CoA reductase gene leads to enhanced artemisinin biosynthesis in transgenic Artemisia annua plants.

21 January 2018

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A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

21 January 2018

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Effect of sugars on artemisinin production in Artemisia annua L.: transcription and metabolite measurements.

21 January 2018

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Reproductive Development Modulates Gene Expression and Metabolite Levels with Possible Feedback Inhibition of Artemisinin in Artemisia annua

21 January 2018

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Effects of antimalarials and protease inhibitors on plasmodial hemozoin production

21 January 2018

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Dihydroartemisinin exerts its anticancer activity through depleting cellular iron via transferrin receptor-1.

21 January 2018

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The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin

21 January 2018

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The translationally controlled tumour protein (TCTP)

21 January 2018

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Calcium pumps in health and disease

21 January 2018

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The biosynthesis of artemisinin (Qinghaosu) and the phytochemistry of Artemisia annua L. (Qinghao).

21 January 2018

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Methyl jasmonate and miconazole differently affect arteminisin production and gene expression in Artemisia annua suspension cultures.

21 January 2018

1 reference

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Artemisinin biosynthesis enhancement in transgenic Artemisia annua plants by downregulation of the β-caryophyllene synthase gene

21 January 2018

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Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum

21 January 2018

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The PI3K pathway as drug target in human cancer

21 January 2018

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21 January 2018

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Stability of peroxide antimalarials in the presence of human hemoglobin

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Stress-Induced Phenylpropanoid Metabolism

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Artemisinins target the SERCA of Plasmodium falciparum

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum

21 January 2018

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Artemisia annua L.: evidence of sesquiterpene lactones' fraction antinociceptive activity

21 January 2018

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Nutrient deficiency in the production of artemisinin, dihydroartemisinic acid, and artemisinic acid in Artemisia annua L.

21 January 2018

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State of the art of the production of the antimalarial compound artemisinin in plants

21 January 2018

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The genetic map of Artemisia annua L. identifies loci affecting yield of the antimalarial drug artemisinin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Hairy root research: recent scenario and exciting prospects

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Effects of overexpression of AaWRKY1 on artemisinin biosynthesis in transgenic Artemisia annua plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

The Fe2+-mediated decomposition, PfATP6 binding, and antimalarial activities of artemisone and other artemisinins: the unlikelihood of C-centered radicals as bioactive intermediates

21 January 2018

1 reference

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Dihydroartemisinin upregulates death receptor 5 expression and cooperates with TRAIL to induce apoptosis in human prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Artemisinins: pharmacological actions beyond anti-malarial

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Artesunate abolishes germinal center B cells and inhibits autoimmune arthritis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Reflections on the 'discovery' of the antimalarial qinghao

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Terpenoids: natural products for cancer therapy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Cloning and characterization of AabHLH1, a bHLH transcription factor that positively regulates artemisinin biosynthesis in Artemisia annua

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Reaction of artemisinin with haemoglobin: implications for antimalarial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Effects of arbuscular mycorrhiza and phosphorus application on artemisinin concentration in Artemisia annua L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug

21 January 2018

1 reference

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Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

AaORA, a trichome-specific AP2/ERF transcription factor of Artemisia annua, is a positive regulator in the artemisinin biosynthetic pathway and in disease resistance to Botrytis cinerea

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Dihydroartemisinin induces apoptosis in colorectal cancer cells through the mitochondria-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Isolation and characterization of AaWRKY1, an Artemisia annua transcription factor that regulates the amorpha-4,11-diene synthase gene, a key gene of artemisinin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Dissection of the phytohormonal regulation of trichome formation and biosynthesis of the antimalarial compound artemisinin in Artemisia annua plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

The reaction of artemisinins with hemoglobin: a unified picture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Sustained synaptic-vesicle recycling by bulk endocytosis contributes to the maintenance of high-rate neurotransmitter release stimulated by glycerotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Toll-like receptors as novel therapeutic targets for ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

The molecular mechanism of action of artemisinin--the debate continues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Relative expression of genes of terpene metabolism in different tissues of Artemisia annua L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

High-level semi-synthetic production of the potent antimalarial artemisinin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Arsenic, chromium and NaCl induced artemisinin biosynthesis in Artemisia annua L.: a valuable antimalarial plant

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

The transferrin receptor: role in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

UV-B and UV-C pre-treatments induce physiological changes and artemisinin biosynthesis in Artemisia annua L. - an antimalarial plant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Production of the antimalarial drug precursor artemisinic acid in engineered yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Alkylation of human hemoglobin A0 by the antimalarial drug artemisinin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

A plausible mechanism for the antimalarial activity of artemisinin: A computational approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Two distinct and competitive pathways confer the cellcidal actions of artemisinins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

The molecular programme of tumour reversion: the steps beyond malignant transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

The use of combining ability analysis to identify elite parents for Artemisia annua F1 hybrid production

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Amplification of Plasmodium falciparum multidrug resistance gene 1 in isolates from Gabon

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Stimulation of artemisinin synthesis by combined cerebroside and nitric oxide elicitation in Artemisia annua hairy roots.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Downmodulation of tumor suppressor p53 by T cell receptor signaling is critical for antigen-specific CD4(+) T cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Pharmacokinetics of artemisinin delivered by oral consumption of Artemisia annua dried leaves in healthy vs. Plasmodium chabaudi-infected mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Qinghaosu (Artemisinin): The Price of Success

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Senescent leaves of Artemisia annua are one of the most active organs for overexpression of artemisinin biosynthesis responsible genes upon burst of singlet oxygen

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Azole fungicides affect mammalian steroidogenesis by inhibiting sterol 14 alpha-demethylase and aromatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Heme activates artemisinin more efficiently than hemin, inorganic iron, or hemoglobin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Development of transgenic Artemisia annua (Chinese wormwood) plants with an enhanced content of artemisinin, an effective anti-malarial drug, by hairpin-RNA-mediated gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Nitric oxide potentiates oligosaccharide-induced artemisinin production in Artemisia annua hairy roots

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00709-015-0805-6

Anti-malarial agent artesunate inhibits TNF-alpha-induced production of proinflammatory cytokines via inhibition of NF-kappaB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes

21 January 2018

1 reference

12 December 2020

Seasonal variation of artemisinin and its biosynthetic precursors in plants of Artemisia annua of different geographical origin: proof for the existence of chemotypes

1 reference

12 December 2020

Dihydroartemisinin suppresses glioma proliferation and invasion via inhibition of the ADAM17 pathway

1 reference

12 December 2020

Modulations of physiological responses and possible involvement of defense-related secondary metabolites in acclimation of Artemisia annua L. against short-term UV-B radiation

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12 December 2020

Overexpression of artemisinic aldehyde Δ11 (13) reductase gene-enhanced artemisinin and its relative metabolite biosynthesis in transgenic Artemisia annua L.

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12 December 2020

Improvement of artemisinin production by chitosan in hairy root cultures of Artemisia annua L

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12 December 2020

Dried whole-plant Artemisia annua slows evolution of malaria drug resistance and overcomes resistance to artemisinin

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12 December 2020

Effect of cadmium on photosynthetic pigments, lipid peroxidation, antioxidants, and artemisinin in hydroponically grown Artemisia annua

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12 December 2020

Dihydroartemisinin inhibits vascular endothelial growth factor-induced endothelial cell migration by a p38 mitogen-activated protein kinase-independent pathway

1 reference

12 December 2020

Expression of a chimeric farnesyl diphosphate synthase gene in Artemisia annua L. transgenic plants via Agrobacterium tumefaciens-mediated transformation

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12 December 2020

Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways

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12 December 2020

Sugars proportionately affect artemisinin production

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12 December 2020

[The preparation of an elicitor from a fungal endophyte to enhance artemisinin production in hairy root cultures of Artemisia annua L]

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12 December 2020

Arsenic-induced changes in morphological, physiological, and biochemical attributes and artemisinin biosynthesis in Artemisia annua, an antimalarial plant

1 reference

12 December 2020

The antimalarial action on Plasmodium falciparum of qinghaosu and artesunate in combination with agents which modulate oxidant stress

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12 December 2020

Yeast model uncovers dual roles of mitochondria in action of artemisinin

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12 December 2020

Artesunate inhibits proliferation of naïve CD4(+) T cells but enhances function of effector T cells

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12 December 2020

Salicylic acid activates artemisinin biosynthesis in Artemisia annua L.

1 reference

12 December 2020

Antimalarial action of artesunate involves DNA damage mediated by reactive oxygen species

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12 December 2020

10.1007/S00709-015-0805-6

Identifiers

DOI

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2 September 2017

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