IL-11 signaling as a therapeutic target for cancer (Q38445355)

3 September 2017

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title

IL-11 signaling as a therapeutic target for cancer (English)

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3 September 2017

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25917632%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

author name string

Tracy L Putoczki

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25917632%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

publication date

1 January 2015

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3 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25917632%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

volume

7

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25917632%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

issue

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25917632%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

page(s)

441-453

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25917632%20AND%20SRC:MED&resulttype=core&format=json

More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancer.

10 June 2020

cites work

1 reference

Targeting IL-11 signaling in colon cancer

21 January 2018

1 reference

Molecular pathways: IL11 as a tumor-promoting cytokine-translational implications for cancers

21 January 2018

1 reference

Interleukin-6 and interleukin-11: same same but different

21 January 2018

1 reference

Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine

21 January 2018

1 reference

The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6

21 January 2018

1 reference

Expression of murine interleukin 11 and its receptor alpha-chain in adult and embryonic tissues

21 January 2018

1 reference

Murine interleukin-11 (IL-11) is expressed at high levels in the hippocampus and expression is developmentally regulated in the testis

21 January 2018

1 reference

Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically

21 January 2018

1 reference

Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

21 January 2018

1 reference

COX-2 induces IL-11 production in human breast cancer cells

21 January 2018

1 reference

Transcriptional regulation of inflammatory mediators secreted by human colonic circular smooth muscle cells.

21 January 2018

1 reference

Regulation of osteoblast differentiation by interleukin-11 via AP-1 and Smad signaling

21 January 2018

1 reference

Interleukin-11 (IL-11) in human endometrium: expression throughout the menstrual cycle and the effects of cytokines on endometrial IL-11 production in vitro

21 January 2018

1 reference

Interleukin-11 links oxidative stress and compensatory proliferation.

21 January 2018

1 reference

IL-11: insights in asthma from overexpression transgenic modeling

21 January 2018

1 reference

IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling.

21 January 2018

1 reference

Interleukin-11 drives early lung inflammation during Mycobacterium tuberculosis infection in genetically susceptible mice

21 January 2018

1 reference

IL-6 type cytokine receptor complexes: hexamer, tetramer or both?

21 January 2018

1 reference

The dynamics of signal triggering in a gp130-receptor complex

21 January 2018

1 reference

Molecular cloning and characterization of the human interleukin-11 receptor alpha-chain gene, IL11RA, located on chromosome 9p13

21 January 2018

1 reference

Functional expression of soluble human interleukin-11 (IL-11) receptor alpha and stoichiometry of in vitro IL-11 receptor complexes with gp130

21 January 2018

1 reference

Structural analysis of the gene encoding the murine interleukin-11 receptor alpha-chain and a related locus.

21 January 2018

1 reference

The role of gp130-mediated signals in osteoclast development: regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures.

21 January 2018

1 reference

Identification of a second murine interleukin-11 receptor alpha-chain gene (IL11Ra2) with a restricted pattern of expression

21 January 2018

1 reference

Interleukin-11 potentiates oligodendrocyte survival and maturation, and myelin formation.

21 January 2018

1 reference

Local overexpression of interleukin-11 in the central nervous system limits demyelination and enhances remyelination.

21 January 2018

1 reference

Expression of interleukin (IL)-11 receptor by the human endometrium in vivo and effects of IL-11, IL-6 and LIF on the production of MMP and cytokines by human endometrial cells in vitro

21 January 2018

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Interleukin 11 is upregulated in uterine lavage and endometrial cancer cells in women with endometrial carcinoma

21 January 2018

1 reference

Interleukin-11 protects against renal ischemia and reperfusion injury

21 January 2018

1 reference

Interleukin‐11 protects the clonogenic stem cells in murine small‐intestinal crypts from impairment of their reproductive capacity by radiation

21 January 2018

1 reference

Interleukin-11 promotes T cell polarization and prevents acute graft-versus-host disease after allogeneic bone marrow transplantation.

21 January 2018

1 reference

Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation

21 January 2018

1 reference

Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.

21 January 2018

1 reference

SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

21 January 2018

1 reference

IL-11 activates human endothelial cells to resist immune-mediated injury

21 January 2018

1 reference

Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation

21 January 2018

1 reference

Protection by recombinant human interleukin-11 against experimental TNB-induced colitis in rats

21 January 2018

1 reference

Thrombopoietic activity of recombinant human interleukin 11 (rHuIL-11) in normal and myelosuppressed nonhuman primates

21 January 2018

1 reference

A multicenter randomized, double-blind, placebo-controlled late-phase II/III study of recombinant human interleukin 11 in acute myelogenous leukemia.

21 January 2018

1 reference

The effect of interleukin 11 on thrombocytopenia associated with tyrosine kinase inhibitor therapy in patients with chronic myeloid leukemia

21 January 2018

1 reference

Phase II study of low-dose interleukin-11 in patients with myelodysplastic syndrome

21 January 2018

1 reference

Low-dose interleukin-11 in patients with bone marrow failure: update of the M. D. Anderson Cancer Center experience

21 January 2018

1 reference

Multicenter, randomized study of genetically modified recombinant human interleukin-11 to prevent chemotherapy-induced thrombocytopenia in cancer patients receiving chemotherapy

21 January 2018

1 reference

Management of chemotherapy-induced thrombocytopenia: current status of thrombopoietic agents

21 January 2018

1 reference

Interleukin-11 signaling is required for the differentiation of natural killer cells at the maternal-fetal interface

21 January 2018

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Recombinant human interleukin-11 does not affect functions of purified human neutrophils in vitro

21 January 2018

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Interleukin-11 reduces TLR4-induced colitis in TLR2-deficient mice and restores intestinal STAT3 signaling.

21 January 2018

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Oral interleukin 11 as a countermeasure to lethal total-body irradiation in a murine model

21 January 2018

1 reference

The protective role of interleukin-11 against neutron radiation injury in mouse intestines via MEK/ERK and PI3K/Akt dependent pathways.

21 January 2018

1 reference

Endogenous interleukin-11 (IL-11) expression is increased and prophylactic use of exogenous IL-11 enhances platelet recovery and improves survival during thrombocytopenia associated with experimental group B streptococcal sepsis in neonatal rats

21 January 2018

1 reference

Interleukin-11-induced heat shock protein 25 confers intestinal epithelial-specific cytoprotection from oxidant stress

21 January 2018

1 reference

A phase I/II double-blind, placebo-controlled study of recombinant human interleukin-11 for mucositis and acute GVHD prevention in allogeneic stem cell transplantation.

21 January 2018

1 reference

Randomized, controlled trial of recombinant human interleukin-11 in patients with active Crohn's disease

21 January 2018

1 reference

Randomized, double blind controlled trial of subcutaneous recombinant human interleukin-11 versus prednisolone in active Crohn's disease.

21 January 2018

1 reference

A protective role of interleukin 11 on hepatic injury in acute endotoxemia

21 January 2018

1 reference

A pilot study of interleukin-11 in subjects with chronic hepatitis C and advanced liver disease nonresponsive to antiviral therapy

21 January 2018

1 reference

A promotor polymorphism in the Interleukin 11 gene is associated with chronic obstructive pulmonary disease

21 January 2018

1 reference

Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation

21 January 2018

1 reference

Erlotinib inhibits osteolytic bone invasion of human non-small-cell lung cancer cell line NCI-H292.

21 January 2018

1 reference

A gene signature of bone metastatic colonization sensitizes for tumor-induced osteolysis and predicts survival in lung cancer.

21 January 2018

1 reference

Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation

21 January 2018

1 reference

Interleukin-11 in endometrial adenocarcinoma is regulated by prostaglandin F2alpha-F-prostanoid receptor interaction via the calcium-calcineurin-nuclear factor of activated T cells pathway and negatively regulated by the regulator of calcineurin-1.

21 January 2018

1 reference

Interleukins-6 and -11 expression in primary breast cancer and subsequent development of bone metastases

21 January 2018

1 reference

Bone metastasis from breast cancer involves elevated IL-11 expression and the gp130/STAT3 pathway.

21 January 2018

1 reference

Cytokine and hormonal stimulation of human osteosarcoma interleukin-11 production.

21 January 2018

1 reference

The interleukin-11 receptor alpha as a candidate ligand-directed target in osteosarcoma: consistent data from cell lines, orthotopic models, and human tumor samples

21 January 2018

1 reference

Expression of interleukin-11 and its encoding mRNA by glioblastoma cells

21 January 2018

1 reference

Enhanced production of CTGF and IL-11 from highly metastatic hepatoma cells under hypoxic conditions: an implication of hepatocellular carcinoma metastasis to bone.

21 January 2018

1 reference

Potential prognostic biomarkers for bone metastasis from hepatocellular carcinoma

21 January 2018

1 reference

Gene expression profile of cytokines and chemokines in microdissected primary Hodgkin and Reed-Sternberg (HRS) cells: high expression of interleukin-11 receptor alpha

21 January 2018

1 reference

Interleukin-11 receptor expression in primary ovarian carcinomas

21 January 2018

1 reference

Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.

21 January 2018

1 reference

Cytokine expression profile in human pancreatic carcinoma cells and in surgical specimens: implications for survival.

21 January 2018

1 reference

Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells

21 January 2018

1 reference

Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate carcinoma

21 January 2018

1 reference

Combinatorial screenings in patients: the interleukin-11 receptor alpha as a candidate target in the progression of human prostate cancer

21 January 2018

1 reference

Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity

21 January 2018

1 reference

Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors

21 January 2018

1 reference

Dietary iron enhances colonic inflammation and IL-6/IL-11-Stat3 signaling promoting colonic tumor development in mice

21 January 2018

1 reference

MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18

21 January 2018

1 reference

IL-11 and IL-11Ralpha immunolocalisation at primate implantation sites supports a role for IL-11 in placentation and fetal development

21 January 2018

1 reference

Lung cancer secreted microvesicles: underappreciated modulators of microenvironment in expanding tumors

21 January 2018

1 reference

Interleukin-11 and leukemia inhibitory factor regulate the adhesion of endometrial epithelial cells: implications in fertility regulation.

21 January 2018

1 reference

Stimulation of interleukin-11 production from osteoblast-like cells by transforming growth factor-beta and tumor cell factors

21 January 2018

1 reference

Production of interleukin-11 in bone-derived endothelial cells and its role in the formation of osteolytic bone metastasis

21 January 2018

1 reference

GP130 cytokines and bone remodelling in health and disease

21 January 2018

1 reference

Interleukin-11: a new cytokine critical for osteoclast development

21 January 2018

1 reference

The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells

21 January 2018

1 reference

Stable Overexpression of Smad7 in Human Melanoma Cells Impairs Bone Metastasis

21 January 2018

1 reference

MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11.

21 January 2018

1 reference

Identification of microRNAs inhibiting TGF-β-induced IL-11 production in bone metastatic breast cancer cells

21 January 2018

1 reference

gp130: a promising drug target for cancer therapy

21 January 2018

1 reference

Genetically modified T cells targeting interleukin-11 receptor α-chain kill human osteosarcoma cells and induce the regression of established osteosarcoma lung metastases

21 January 2018

1 reference

The role of IL-II in hematopoiesis as revealed by a targeted mutation of its receptor

21 January 2018

1 reference

JAK inhibitors for myeloproliferative neoplasms: clarifying facts from myths

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/IMT.15.17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25917632%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference