Targeting interferons in systemic lupus erythematosus: current and future prospects (Q38458846)

3 September 2017

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title

Targeting interferons in systemic lupus erythematosus: current and future prospects (English)

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systemic lupus erythematosus

3 September 2017

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4

Zahir Amoura

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3 September 2017

Alexis Mathian

1

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3 September 2017

Miguel Hie

series ordinal

2

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3 September 2017

Fleur Cohen-Aubart

series ordinal

3

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3 September 2017

publication date

1 May 2015

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3 September 2017

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3 September 2017

volume

75

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3 September 2017

issue

8

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3 September 2017

page(s)

835-846

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Morbidity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort of 1,000 patients

3 September 2017

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Modular transcriptional repertoire analyses of adults with systemic lupus erythematosus reveal distinct type I and type II interferon signatures

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Possible involvement of interferon alfa in the pathogenesis of fever in systemic lupus erythematosus

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Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies

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Type I interferon correlates with serological and clinical manifestations of SLE

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Development of Potential Pharmacodynamic and Diagnostic Markers for Anti-IFN-α Monoclonal Antibody Trials in Systemic Lupus Erythematosus

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Use of type I interferon-inducible mRNAs as pharmacodynamic markers and potential diagnostic markers in trials with sifalimumab, an anti-IFNα antibody, in systemic lupus erythematosus.

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Activation of the interferon-alpha pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease.

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Longitudinal expression of type I interferon responsive genes in systemic lupus erythematosus

21 January 2018

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Identification of distinct gene expression profiles in the synovium of patients with systemic lupus erythematosus.

21 January 2018

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Neutralization of interferon-alpha/beta-inducible genes and downstream effect in a phase I trial of an anti-interferon-alpha monoclonal antibody in systemic lupus erythematosus

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Elevated serum levels of interferon-regulated chemokines are biomarkers for active human systemic lupus erythematosus

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Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity: a validation study

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IFNα and its response proteins, IP-10 and SIGLEC-1, are biomarkers of disease activity in systemic lupus erythematosus

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Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice

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Deficiency of the type I interferon receptor protects mice from experimental lupus

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Systemic IFN-alpha drives kidney nephritis in B6.Sle123 mice

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Interferon-α induces unabated production of short-lived plasma cells in pre-autoimmune lupus-prone (NZB×NZW)F1 mice but not in BALB/c mice

21 January 2018

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IFNalpha kinoid vaccine-induced neutralizing antibodies prevent clinical manifestations in a lupus flare murine model

21 January 2018

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Active immunisation of human interferon α transgenic mice with a human interferon α Kinoid induces antibodies that neutralise interferon α in sera from patients with systemic lupus erythematosus.

21 January 2018

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TLR9 independent interferon α production by neutrophils on NETosis in response to circulating chromatin, a key lupus autoantigen

21 January 2018

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The nature of the principal type 1 interferon-producing cells in human blood

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Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha/beta, IFN-gamma, and IFN-lambda in host defense

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Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice

21 January 2018

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Treatment of murine lupus with cDNA encoding IFN-gammaR/Fc

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21 January 2018

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Population pharmacokinetics of sifalimumab, an investigational anti-interferon-α monoclonal antibody, in systemic lupus erythematosus

21 January 2018

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Sifalimumab, a human anti-interferon-α monoclonal antibody, in systemic lupus erythematosus: a phase I randomized, controlled, dose-escalation study

21 January 2018

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The CLASI (Cutaneous Lupus Erythematosus Disease Area and Severity Index): an outcome instrument for cutaneous lupus erythematosus

21 January 2018

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Down-regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon α-kinoid

21 January 2018

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Trichostatin A blocks type I interferon production by activated plasmacytoid dendritic cells

21 January 2018

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Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model

21 January 2018

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Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjögren's syndrome

21 January 2018

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A phase 1b clinical trial evaluating sifalimumab, an anti-IFN-α monoclonal antibody, shows target neutralisation of a type I IFN signature in blood of dermatomyositis and polymyositis patients

21 January 2018

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Dose-escalation of human anti-interferon-α receptor monoclonal antibody MEDI-546 in subjects with systemic sclerosis: a phase 1, multicenter, open label study

21 January 2018

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Interferons, immunity and cancer immunoediting

21 January 2018

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Novel evidence-based systemic lupus erythematosus responder index

21 January 2018

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Combined oral contraceptives in women with systemic lupus erythematosus

21 January 2018

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Pharmacokinetic and pharmacodynamic relationship of AMG 811, an anti-IFN-γ IgG1 monoclonal antibody, in patients with systemic lupus erythematosus

21 January 2018

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Type I Interferon controls the onset and severity of autoimmune manifestations in lpr mice

21 January 2018

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12 December 2020

A randomized, double-blind, placebo-controlled, phase I study of MEDI-545, an anti-interferon-alfa monoclonal antibody, in subjects with chronic psoriasis

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JAK2 inhibition in murine systemic lupus erythematosus

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Experimental therapy of systemic lupus erythematosus: the treatment of NZB/W mice with mouse soluble interferon-gamma receptor inhibits the onset of glomerulonephritis

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Interferon expression in the pancreases of patients with type I diabetes

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Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway

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12 December 2020

Anti-double-stranded DNA antibodies and immunostimulatory plasmid DNA in combination mimic the endogenous IFN-alpha inducer in systemic lupus erythematosus

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The BILAG index: a reliable and valid instrument for measuring clinical disease activity in systemic lupus erythematosus.

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Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms

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Autoimmunity after alpha-interferon therapy for malignant carcinoid tumors

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Patients with systemic lupus erythematosus (SLE) have a circulating inducer of interferon-alpha (IFN-alpha) production acting on leucocytes resembling immature dendritic cells

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12 December 2020

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12 December 2020

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12 December 2020

Expression of the markers BDCA-2 and BDCA-4 and production of interferon-alpha by plasmacytoid dendritic cells in systemic lupus erythematosus

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12 December 2020

Activation of natural interferon-alpha producing cells by apoptotic U937 cells combined with lupus IgG and its regulation by cytokines

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12 December 2020

IFN-gamma is essential for the development of autoimmune glomerulonephritis in MRL/Ipr mice

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12 December 2020

Bcl-2 Antagonists Kill Plasmacytoid Dendritic Cells From Lupus-Prone Mice and Dampen Interferon-α Production

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12 December 2020

Serum interferon levels in patients with systemic lupus erythematosus

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12 December 2020

Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus

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12 December 2020

IFN-alpha induces early lethal lupus in preautoimmune (New Zealand Black x New Zealand White) F1 but not in BALB/c mice

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12 December 2020

10.1007/S40265-015-0394-X

Identifiers

DOI

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Dimensions Publication ID

3 September 2017

1046594614

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