Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy. (Q38547464)

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scientific article published on 12 February 2016

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English	Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy.	scientific article published on 12 February 2016

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scholarly article

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9 March 2020

Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy (English)

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9 March 2020

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extracellular matrix

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Fucus vesiculosus

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Fucus vesiculosus

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9 March 2020

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Yingqun Zhou

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9 March 2020

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Kan Chen

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9 March 2020

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Yujing Xia

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9 March 2020

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Shunfeng Zhou

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9 March 2020

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Tong Liu

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9 March 2020

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Jingjing Li

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9 March 2020

Sainan Li

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9 March 2020

Jiao Feng

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9 March 2020

Fan Wang

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9 March 2020

Rong Zhang

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9 March 2020

Shizan Xu

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9 March 2020

Yuqing Zhou

9

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9 March 2020

Jie Lu

12

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9 March 2020

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12 February 2016

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9 March 2020

Drug Design, Development and Therapy

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9 March 2020

10

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9 March 2020

619-630

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9 March 2020

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Creative Commons Attribution-NonCommercial 3.0 Unported

1 February 2016

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April 2022 Public Data File from Crossref

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Strategies to prevent and reverse liver fibrosis in humans and laboratory animals

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Endoglin Regulation of Smad2 Function Mediates Beclin1 Expression and Endothelial Autophagy

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Autophagy is a regulator of TGF-β1-induced fibrogenesis in primary human atrial myofibroblasts

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Protective effects of astaxanthin on ConA-induced autoimmune hepatitis by the JNK/p-JNK pathway-mediated inhibition of autophagy and apoptosis.

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Bile duct ligation in mice: induction of inflammatory liver injury and fibrosis by obstructive cholestasis

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6 September 2017

Fucoidan from Fucus vesiculosus protects against alcohol-induced liver damage by modulating inflammatory mediators in mice and HepG2 cells

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Combination therapy of ursodeoxycholic acid and budesonide for PBC-AIH overlap syndrome: a meta-analysis

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Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis

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N-acetylcysteine attenuates ischemia-reperfusion-induced apoptosis and autophagy in mouse liver via regulation of the ROS/JNK/Bcl-2 pathway.

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Hydrogen sulfide, a potential novel drug, attenuates concanavalin A-induced hepatitis.

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Autophagy: a housekeeper in cardiorenal metabolic health and disease

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Role of autophagy in the pathophysiology of nonalcoholic fatty liver disease: a controversial issue

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Hydrogen sulfide ameliorates ischemia/reperfusion-induced hepatitis by inhibiting apoptosis and autophagy pathways

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6 September 2017

Protective effect of astaxanthin on liver fibrosis through modulation of TGF-β1 expression and autophagy.

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6 September 2017

Fucoidan as a marine anticancer agent in preclinical development

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6 September 2017

Ethyl pyruvate ameliorates hepatic ischemia-reperfusion injury by inhibiting intrinsic pathway of apoptosis and autophagy

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6 September 2017

High expression of IGFBP7 in fibroblasts induced by colorectal cancer cells is co-regulated by TGF-β and Wnt signaling in a Smad2/3-Dvl2/3-dependent manner

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Hepatic stellate cells and liver fibrosis

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Brown seaweed fucoidan: biological activity and apoptosis, growth signaling mechanism in cancer

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Crosstalk between apoptosis, necrosis and autophagy

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Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease

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Losartan alleviates renal fibrosis by down-regulating HIF-1α and up-regulating MMP-9/TIMP-1 in rats with 5/6 nephrectomy

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The crosstalk between autophagy and apoptosis: where does this lead?

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Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues.

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Therapies from fucoidan; multifunctional marine polymers

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Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression

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Involvement of autophagy in alcoholic liver injury and hepatitis C pathogenesis

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Mechanisms of hepatic fibrogenesis

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Human neutrophil elastase-mediated cleavage sites of MMP-9 and TIMP-1: implications to cystic fibrosis proteolytic dysfunction

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Fucoidan inhibits UVB-induced MMP-1 promoter expression and down regulation of type I procollagen synthesis in human skin fibroblasts

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6 September 2017

The global impact of hepatic fibrosis and end-stage liver disease.

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Hepatic fibrosis -- overview

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Liver cirrhosis

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Fucoidan partly prevents CCl4-induced liver fibrosis

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Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets

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6 September 2017

Activation of hepatic stellate cells--a key issue in liver fibrosis

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6 September 2017

Collagenase in experimental carbon tetrachloride cirrhosis of the liver

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6 September 2017

Advanced glycation end product (AGE)-induced hepatic stellate cell activation via autophagy contributes to hepatitis C-related fibrosis

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27 September 2017

Ghrelin reduces liver impairment in a model of concanavalin A-induced acute hepatitis in mice

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27 September 2017

Chloroquine improved carbon tetrachloride-induced liver fibrosis through its inhibition of the activation of hepatic stellate cells: role of autophagy

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23 June 2018

Hepatitis C virus core protein activates autophagy through EIF2AK3 and ATF6 UPR pathway-mediated MAP1LC3B and ATG12 expression

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23 June 2018

The role of Smad3 in mediating mouse hepatic stellate cell activation

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Low-molecular-weight fibroblast growth factor 2 attenuates hepatic fibrosis by epigenetic down-regulation of Delta-like1.

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[Effect of autophagy inhibitor 3-methyladenine on proliferation and activation of hepatic stellate cells].

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Hepatic fibrosis: role of matrix metalloproteases and TGFbeta

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31 August 2018

Fucoidan, a sulfated polysaccharide from brown algae, against myocardial ischemia-reperfusion injury in rats via regulating the inflammation response

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver fibrosis. Foreword

1 reference

https://pubmed.ncbi.nlm.nih.gov/26929597

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression by fucoidan of liver fibrogenesis via the TGF-β/Smad pathway in protecting against oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/26929597

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy: a new player in hepatic stellate cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26929597

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2147/DDDT.S98740

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26929597%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26929597%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26929597%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

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