A fascination with enzymes: the journey not the arrival matters (Q38575125)

4 September 2017

title

A fascination with enzymes: the journey not the arrival matters (English)

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4 September 2017

Paul Talalay

1

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4 September 2017

language of work or name

English

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publication date

7 June 2005

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Journal of Biological Chemistry

4 September 2017

published in

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4 September 2017

volume

280

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4 September 2017

issue

32

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4 September 2017

page(s)

28829-28847

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STUDIES ON PROSTATIC CANCER

4 September 2017

cites work

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ACTIVATION OF HYDROGEN TRANSFER BETWEEN PYRIDINE NUCLEOTIDES BY STEROID HORMONES.

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ON A COENZYMATIC FUNCTION OF ESTRADIOL-17beta

21 January 2018

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Enzymatic formation of testololactone

21 January 2018

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Enzymatic oxidation of steroids by cell-free extracts of Pseudomonas testosteroni: isolation of cleavage products of ring A

21 January 2018

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Formation, functions and regulatory importance of S-adenosyl-L-methionine

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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

21 January 2018

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Isolation and sequencing of the gene encoding delta 5-3-ketosteroid isomerase of Pseudomonas testosteroni: overexpression of the protein

21 January 2018

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Catalytic mechanism of an active-site mutant (D38N) of delta 5-3-ketosteroid isomerase. Direct spectroscopic evidence for dienol intermediates

21 January 2018

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NMR evidence for the participation of a low-barrier hydrogen bond in the mechanism of delta 5-3-ketosteroid isomerase

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Solution structure of 3-oxo-delta5-steroid isomerase

21 January 2018

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Crystal structure of delta(5)-3-ketosteroid isomerase from Pseudomonas testosteroni in complex with equilenin settles the correct hydrogen bonding scheme for transition state stabilization

21 January 2018

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The Δ5-3-ketosteroid isomerase reaction: catalytic mechanism, specificity and inhibition

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Inactivation of Δ5-3-oxo steroid isomerase with active-site-directed acetylenic steroids

21 January 2018

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Relationship between the soluble glutathione-dependent delta 5-3-ketosteroid isomerase and the glutathione S-transferases of the liver

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Active-site residues governing high steroid isomerase activity in human glutathione transferase A3-3

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Chemoprotection against cancer by induction of phase 2 enzymes

21 January 2018

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Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis

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Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers.

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21 January 2018

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Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity

21 January 2018

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Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen

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Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: A screening assay for anticarcinogenic enzyme inducers

21 January 2018

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Induction of NAD(P)H:quinone reductase in murine hepatoma cells by phenolic antioxidants, azo dyes, and other chemoprotectors: a model system for the study of anticarcinogens

21 January 2018

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Rapid detection of inducers of enzymes that protect against carcinogens

21 January 2018

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Purification and crystallization of rat liver NAD(P)H:(quinone-acceptor) oxidoreductase by cibacron blue affinity chromatography: identification of a new and potent inhibitor

21 January 2018

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The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction

21 January 2018

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Crystal structure of human quinone reductase type 2, a metalloflavoprotein

21 January 2018

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Structure and mechanism of NAD[P]H:quinone acceptor oxidoreductases (NQO).

21 January 2018

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A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure

21 January 2018

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Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates

21 January 2018

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Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes

21 January 2018

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Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens

21 January 2018

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Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors

21 January 2018

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On the mechanisms of induction of cancer-protective enzymes: a unifying proposal

21 January 2018

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Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis

21 January 2018

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The "Prochaska" microtiter plate bioassay for inducers of NQO1.

21 January 2018

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Induction of quinone reductase as a primary screen for natural product anticarcinogens

21 January 2018

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Chemical structures of inducers of nicotinamide quinone oxidoreductase 1 (NQO1).

21 January 2018

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Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

21 January 2018

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Chemical and molecular regulation of enzymes that detoxify carcinogens

21 January 2018

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The electrophile counterattack response: protection against neoplasia and toxicity.

21 January 2018

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

21 January 2018

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

21 January 2018

1 reference

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Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

21 January 2018

1 reference

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Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein.

21 January 2018

1 reference

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Enzymatic Formation of 3α-Hydroxysteroids

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.X500004200

1 reference

release_zxhetn7f6jcznfqb4du5gprbtu

4 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/zxhetn7f6jcznfqb4du5gprbtu

mapped directly with Wikidata item

24 November 2022

based on heuristic

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