Mystery of the brain metastatic disease in breast cancer patients: improved patient stratification, disease prediction and targeted prevention on the horizon? (Q38616628)

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English	Mystery of the brain metastatic disease in breast cancer patients: improved patient stratification, disease prediction and targeted prevention on the horizon?	scientific article

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27 March 2020

Mystery of the brain metastatic disease in breast cancer patients: improved patient stratification, disease prediction and targeted prevention on the horizon? (English)

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27 March 2020

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Jiri Polivka

1

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27 March 2020

Jiri Polivka

3

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27 March 2020

Christina Kaiser

4

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27 March 2020

Walther Kuhn

5

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27 March 2020

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13 March 2017

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27 March 2020

The EPMA journal

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27 March 2020

8

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27 March 2020

2

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27 March 2020

119-127

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27 March 2020

https://scigraph.springernature.com/pub.10.1007/s13167-017-0087-5

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αB-crystallin Expression in Breast Cancer is Associated with Brain Metastasis

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23 June 2018

Targeted Therapies for Brain Metastases from Breast Cancer

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23 June 2018

Breast cancer epidemic in the early twenty-first century: evaluation of risk factors, cumulative questionnaires and recommendations for preventive measures

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23 June 2018

Blood-brain barrier remodeling during brain metastasis formation

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23 June 2018

Risk factors for brain metastasis as a first site of disease recurrence in patients with HER2 positive early stage breast cancer treated with adjuvant trastuzumab.

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23 June 2018

Breast cancer brain metastases: biology and new clinical perspectives

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23 June 2018

Diversity of Breast Carcinoma: Histological Subtypes and Clinical Relevance

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23 June 2018

EGFR and HER2 signaling in breast cancer brain metastasis

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23 June 2018

Breast cancer brain metastases: the last frontier

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23 June 2018

Testing for oncogenic molecular aberrations in cell-free DNA-based liquid biopsies in the clinic: are we there yet?

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23 June 2018

Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets

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23 June 2018

CXCR4 in breast cancer: oncogenic role and therapeutic targeting

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23 June 2018

A hypoxic ticket to the bone metastatic niche

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase.

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23 June 2018

Validation and Development of a Modified Breast Graded Prognostic Assessment As a Tool for Survival in Patients With Breast Cancer and Brain Metastases

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Breast cancer brain metastases: evidence for neuronal-like adaptation in a 'breast-to-brain' transition?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Pathogenesis of Breast Cancer Metastasis to Brain: a Comprehensive Approach to the Signaling Network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Role of the neural niche in brain metastatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

New treatment paradigm for patients with anaplastic oligodendroglial tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Incidence of central nervous system metastases in patients with HER2-positive metastatic breast cancer treated with pertuzumab, trastuzumab, and docetaxel: results from the randomized phase III study CLEOPATRA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Effect of age and biological subtype on the risk and timing of brain metastasis in breast cancer patients

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Integrated genomic and epigenomic analysis of breast cancer brain metastasis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Human breast cancer metastases to the brain display GABAergic properties in the neural niche

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

αB-crystallin: a novel regulator of breast cancer metastasis to the brain

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Incidence and risk of central nervous system metastases as site of first recurrence in patients with HER2-positive breast cancer treated with adjuvant trastuzumab

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Co-evolution of breast-to-brain metastasis and neural progenitor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Comprehensive molecular portraits of human breast tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

A nomogram for individualized estimation of survival among patients with brain metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Phosphatidylinositol 3-kinase pathway activation in breast cancer brain metastases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Genomic analysis identifies unique signatures predictive of brain, lung, and liver relapse.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Notch1 inhibition alters the CD44hi/CD24lo population and reduces the formation of brain metastases from breast cancer.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Metastatic behavior of breast cancer subtypes

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Nomogram to predict subsequent brain metastasis in patients with metastatic breast cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Genes that mediate breast cancer metastasis to the brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Reactive glia are recruited by highly proliferative brain metastases of breast cancer and promote tumor cell colonization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Activation of notch signaling in a xenograft model of brain metastasis

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23 June 2018

Trastuzumab in the adjuvant treatment of early-stage breast cancer: a systematic review and meta-analysis of randomized controlled trials

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Subtypes of breast cancer show preferential site of relapse

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23 June 2018

Adjuvant trastuzumab in the treatment of her-2-positive early breast cancer: a meta-analysis of published randomized trials

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23 June 2018

Cardiotoxicity and incidence of brain metastases after adjuvant trastuzumab for early breast cancer: the dark side of the moon? A meta-analysis of the randomized trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Breast cancers with brain metastases are more likely to be estrogen receptor negative, express the basal cytokeratin CK5/6, and overexpress HER2 or EGFR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Identifying breast cancer patients at risk for Central Nervous System (CNS) metastases in trials of the International Breast Cancer Study Group (IBCSG).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Genes that mediate breast cancer metastasis to lung

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

CNS metastases in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Involvement of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1alpha in breast cancer cell migration through human brain microvascular endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Vascular endothelial growth factor expression promotes the growth of breast cancer brain metastases in nude mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Diagnosis and Management of Central Nervous System Metastases from Breast Cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Vascular endothelial growth factor modulates the transendothelial migration of MDA-MB-231 breast cancer cells through regulation of brain microvascular endothelial cell permeability

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Molecular portraits of human breast tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

23 June 2018

Identifying risk factors for brain metastasis in breast cancer patients: Implication for a vigorous surveillance program

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

31 August 2018

Breast cancer subtypes predispose the site of distant metastases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

31 August 2018

CEREBEL (EGF111438): A Phase III, Randomized, Open-Label Study of Lapatinib Plus Capecitabine Versus Trastuzumab Plus Capecitabine in Patients With Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

31 August 2018

Co-overexpression of HER2/HER3 is a predictor of impaired survival in breast cancer patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

31 August 2018

Angiopoietin-2 mediates blood-brain barrier impairment and colonization of triple-negative breast cancer cells in brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

31 August 2018

Immunohistochemical prediction of brain metastases in patients with advanced breast cancer: the role of Rad51.

1 reference

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31 August 2018

CNS relapses in patients with HER2-positive early breast cancer who have and have not received adjuvant trastuzumab: a retrospective substudy of the HERA trial (BIG 1-01).

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31 August 2018

Retrospective analysis of risk factors for central nervous system metastases in operable breast cancer: effects of biologic subtype and Ki67 overexpression on survival

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31 August 2018

Predicting survival in women with breast cancer and brain metastasis: a nomogram outperforms current survival prediction models

1 reference

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31 August 2018

Cerebral metastases in metastatic breast cancer: disease-specific risk factors and survival.

1 reference

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31 August 2018

Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way.

1 reference

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31 August 2018

Triple-negative and HER2-overexpressing breast cancers exhibit an elevated risk and an earlier occurrence of cerebral metastases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

31 August 2018

Primary breast cancer phenotypes associated with propensity for central nervous system metastases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5545987

31 August 2018

Medicine in the early twenty-first century: paradigm and anticipation - EPMA position paper 2016

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https://api.crossref.org/works/10.1007%2FS13167-017-0087-5

21 January 2018

Erratum: Integrated genomic analyses of ovarian carcinoma

1 reference

https://api.crossref.org/works/10.1007%2FS13167-017-0087-5

21 January 2018

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10.1007/S13167-017-0087-5

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Europe PubMed Central

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27 March 2020

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27 March 2020

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Europe PubMed Central

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27 March 2020

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