Tau-imaging in neurodegeneration (Q38633337)

5 September 2017

title

Tau-imaging in neurodegeneration (English)

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5 September 2017

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Alexander Drzezga

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author name string

Gérard N Bischof

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1

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5 September 2017

Heike Endepols

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2

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5 September 2017

Thilo van Eimeren

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3

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5 September 2017

publication date

5 August 2017

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5 September 2017

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Frequency of stages of Alzheimer-related lesions in different age categories

5 September 2017

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Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.

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Atomic structures of amyloid cross-beta spines reveal varied steric zippers

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Research towards tau imaging

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The repeat region of microtubule-associated protein tau forms part of the core of the paired helical filament of Alzheimer's disease

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QSAR studies for prediction of cross-β sheet aggregate binding affinity and selectivity

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Ligand polarizability contributes to tau fibril binding affinity.

7 January 2021

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Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807.

7 January 2021

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Tau imaging in neurodegenerative diseases

7 January 2021

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Tau positron emission tomographic imaging in aging and early Alzheimer disease

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[18F]AV-1451 tau-PET uptake does correlate with quantitatively measured 4R-tau burden in autopsy-confirmed corticobasal degeneration.

7 January 2021

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[(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease

7 January 2021

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Development of [11C]/[3H]THK-5351 - A potential novel carbon-11 tau imaging PET radioligand

7 January 2021

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Structure-Activity Relationship of 2-Arylquinolines as PET Imaging Tracers for Tau Pathology in Alzheimer Disease.

7 January 2021

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Radiosynthesis, photoisomerization, biodistribution, and metabolite analysis of 11C-PBB3 as a clinically useful PET probe for imaging of tau pathology.

7 January 2021

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Synthesis of a PET tau tracer [(11)C]PBB3 for imaging of Alzheimer's disease.

7 January 2021

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Preclinical Characterization of 18F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles.

7 January 2021

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7 January 2021

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Preclinical Evaluation of 18F-JNJ64349311, a Novel PET Tracer for Tau Imaging

7 January 2021

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Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue

7 January 2021

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An autoradiographic evaluation of AV-1451 Tau PET in dementia

7 January 2021

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Characterization of tau positron emission tomography tracer [18F]AV-1451 binding to postmortem tissue in Alzheimer's disease, primary tauopathies, and other dementias

7 January 2021

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Tau imaging with [18 F]THK-5351 in progressive supranuclear palsy

7 January 2021

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In vivo visualization of tau deposits in corticobasal syndrome by 18F-THK5351 PET.

7 January 2021

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Characteristics of Tau and Its Ligands in PET Imaging

7 January 2021

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Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls

7 January 2021

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PET Quantification of Tau Pathology in Human Brain with 11C-PBB3.

7 January 2021

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Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

7 January 2021

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7 January 2021

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Tau suppression in a neurodegenerative mouse model improves memory function

7 January 2021

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Small-Animal PET Imaging of Tau Pathology with 18F-THK5117 in 2 Transgenic Mouse Models

7 January 2021

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In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum.

7 January 2021

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PET Imaging of Tau Deposition in the Aging Human Brain.

7 January 2021

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Regional profiles of the candidate tau PET ligand 18F-AV-1451 recapitulate key features of Braak histopathological stages.

7 January 2021

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Imaging in-vivo tau pathology in Alzheimer's disease with THK5317 PET in a multimodal paradigm

7 January 2021

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In vivo Patterns of Tau Pathology, Amyloid-β Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer's Disease.

7 January 2021

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Tau, amyloid, and hypometabolism in a patient with posterior cortical atrophy

7 January 2021

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Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease.

7 January 2021

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In vivo imaging of neuromelanin in Parkinson's disease using 18F-AV-1451 PET.

7 January 2021

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[F-18]AV-1451 positron emission tomography retention in choroid plexus: More than "off-target" binding

7 January 2021

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Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

7 January 2021

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7 January 2021

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PART is part of Alzheimer disease

7 January 2021

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Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease

7 January 2021

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TAU-PET PATTERNS OVERLAP AND EXCEED HYPOMETABOLISM IN ALZHEIMER'S DISEASE

7 January 2021

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Posterior Accumulation of Tau and Concordant Hypometabolism in an Early-Onset Alzheimer's Disease Patient with Presenilin-1 Mutation.

7 January 2021

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Elevated in vivo [18F]-AV-1451 uptake in a patient with progressive supranuclear palsy.

7 January 2021

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[18 F]AV-1451 tau positron emission tomography in progressive supranuclear palsy

7 January 2021

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Multimodal evaluation demonstrates in vivo 18F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration

7 January 2021

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Tau neuropathology correlates with FDG-PET, but not AV-1451-PET, in progressive supranuclear palsy

7 January 2021

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Dementia with Lewy bodies from the perspective of tauopathy

7 January 2021

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Convergence of Lewy bodies and neurofibrillary tangles in amygdala neurons of Alzheimer's disease and Lewy body disorders

7 January 2021

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Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study.

7 January 2021

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Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and a severe head injury.

7 January 2021

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Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature

7 January 2021

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Pharmacokinetic Evaluation of the Tau PET Radiotracer 18F-T807 (18F-AV-1451) in Human Subjects.

7 January 2021

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Neurofibrillary Tangle Stage and the Rate of Progression of Alzheimer Symptoms: Modeling Using an Autopsy Cohort and Application to Clinical Trial Design

7 January 2021

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Human Radiation Dosimetry of [(18)F]AV-1451(T807) to Detect Tau Pathology.

7 January 2021

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Biodistribution and Radiation Dosimetry for the Tau Tracer 18F-THK-5351 in Healthy Human Subjects.

7 January 2021

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Reference Tissue-Based Kinetic Evaluation of 18F-AV-1451 for Tau Imaging.

7 January 2021

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Modeling Strategies for Quantification of In Vivo 18F-AV-1451 Binding in Patients with Tau Pathology.

7 January 2021

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Identification of a major radiometabolite of [11C]PBB3.

7 January 2021

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Tracer Kinetic Analysis of (S)-¹⁸F-THK5117 as a PET Tracer for Assessing Tau Pathology.

7 January 2021

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A new method to quantify tau pathologies with (11)C-PBB3 PET using reference tissue voxels extracted from brain cortical gray matter.

7 January 2021

1 reference

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Kinetics of the Tau PET Tracer 18F-AV-1451 (T807) in Subjects with Normal Cognitive Function, Mild Cognitive Impairment, and Alzheimer Disease

7 January 2021

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18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology in MAPT mutation carriers

7 January 2021

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[18F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation.

7 January 2021

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Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies.

7 January 2021

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10.1016/J.YMETH.2017.08.003

7 January 2021

Identifiers

DOI

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5 September 2017

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