Correlating conformational shift induction with altered inhibitor potency in a multidrug resistant HIV-1 protease variant. (Q38647981)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23009326%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

title

Correlating conformational shift induction with altered inhibitor potency in a multidrug resistant HIV-1 protease variant (English)

1 reference

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9 March 2020

main subject

multiple drug resistance

1 reference

inferred from title

author

Ian Mitchelle S De Vera

series ordinal

1

1 reference

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9 March 2020

author name string

Mandy E Blackburn

series ordinal

2

1 reference

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9 March 2020

Gail E Fanucci

series ordinal

3

1 reference

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9 March 2020

language of work or name

English

0 references

publication date

28 September 2012

1 reference

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9 March 2020

number of pages

3

1 reference

inferred from page(s)

published in

Biochemistry

1 reference

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9 March 2020

volume

51

1 reference

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9 March 2020

issue

40

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9 March 2020

page(s)

7813-7815

1 reference

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HIV-1 Protease: Structural Perspectives on Drug Resistance

9 March 2020

cites work

1 reference

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6 September 2017

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Nine crystal structures determine the substrate envelope of the MDR HIV-1 protease

6 September 2017

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6 September 2017

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The Effect of Clade-Specific Sequence Polymorphisms on HIV-1 Protease Activity and Inhibitor Resistance Pathways

6 September 2017

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Solution structure of HIV-1 protease flaps probed by comparison of molecular dynamics simulation ensembles and EPR experiments

6 September 2017

1 reference

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Effect of the Active Site D25N Mutation on the Structure, Stability, and Ligand Binding of the Mature HIV-1 Protease

6 September 2017

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HIV-1 protease: structure, dynamics, and inhibition

6 September 2017

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Recent advances and applications of site-directed spin labeling.

6 September 2017

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HIV-1 protease flaps spontaneously open and reclose in molecular dynamics simulations

6 September 2017

1 reference

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Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity

6 September 2017

1 reference

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Drug resistance in HIV-1 protease: Flexibility-assisted mechanism of compensatory mutations

6 September 2017

1 reference

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Curling of flap tips in HIV-1 protease as a mechanism for substrate entry and tolerance of drug resistance

6 September 2017

1 reference

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Sequence requirements of the HIV-1 protease flap region determined by saturation mutagenesis and kinetic analysis of flap mutants

6 September 2017

1 reference

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HIV protease: a novel chemotherapeutic target for AIDS.

6 September 2017

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The three-dimensional structure of the aspartyl protease from the HIV-1 isolate BRU

6 September 2017

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HIV-1 protease mutations and protease inhibitor cross-resistance

6 September 2017

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Subtype polymorphisms among HIV-1 protease variants confer altered flap conformations and flexibility

23 June 2018

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"Wide-open" 1.3 A structure of a multidrug-resistant HIV-1 protease as a drug target

23 June 2018

1 reference

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Highly drug-resistant HIV-1 clinical isolates are cross-resistant to many antiretroviral compounds in current clinical development

23 June 2018

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Reaction path and free energy calculations of the transition between alternate conformations of HIV-1 protease

23 June 2018

1 reference

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Drug pressure selected mutations in HIV-1 protease alter flap conformations

23 June 2018

1 reference

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Secondary mutations M36I and A71V in the human immunodeficiency virus type 1 protease can provide an advantage for the emergence of the primary mutation D30N.

31 August 2018

1 reference

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Dynamics of "flap" structures in three HIV-1 protease/inhibitor complexes probed by total chemical synthesis and pulse-EPR spectroscopy

31 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23009326

12 December 2020

inferred from PubMed ID database lookup

Monitoring inhibitor-induced conformational population shifts in HIV-1 protease by pulsed EPR spectroscopy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23009326

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1021/BI301010Z

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23009326%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23009326%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

PubMed publication ID

23009326

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23009326%20AND%20SRC:MED&resulttype=core&format=json