Zidovudine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy (Q38649719)

5 September 2017

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title

Zidovudine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy (English)

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5 September 2017

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Langtry HD

1

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PubMed ID

2661194

5 September 2017

Campoli-Richards DM

series ordinal

2

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5 September 2017

1 April 1989

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5 September 2017

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5 September 2017

37

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5 September 2017

408-450

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5 September 2017

4

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https://scigraph.springernature.com/pub.10.2165/00003495-198937040-00003

5 September 2017

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Azidothymidine in the treatment of AIDS

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Necrotising myopathy and zidovudine

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Suppression of human immunodeficiency virus replication by 3'-azido-3'-deoxythymidine in various human hematopoietic cell lines in vitro: augmentation of the effect by lentinan.

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Treatment of HIV-induced retinoid-resistant psoriasis with zidovudine

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Severe polymyositis-like syndrome associated with zidovudine therapy of AIDS and ARC.

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Possible zidovudine-induced hepatotoxicity

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12 December 2020

Site-specific mutagenesis of AIDS virus reverse transcriptase

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12 December 2020

Possible drug interaction during therapy with azidothymidine and acyclovir for AIDS.

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12 December 2020

Acute meningo-encephalitis on dose reduction of zidovudine

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12 December 2020

Uridine reverses the toxicity of 3'-azido-3'-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity

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12 December 2020

Significant changes in HIV antigen level in the serum of patients treated with azidothymidine.

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12 December 2020

Toxicity of 3'-azido-3'-deoxythymidine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine for normal human hematopoietic progenitor cells in vitro

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12 December 2020

Manic syndrome associated with zidovudine treatment

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12 December 2020

3'-Azido-3'-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase

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12 December 2020

"Cure" of chronic cryptosporidiosis during treatment with azidothymidine in a patient with the acquired immune deficiency syndrome

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12 December 2020

Antiviral activity of 2',3'-dideoxycytidin-2'-ene (2',3'-dideoxy-2',3'-didehydrocytidine) against human immunodeficiency virus in vitro

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12 December 2020

Acquired immunodeficiency syndrome-associated psoriasis and Reiter's syndrome

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12 December 2020

Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDS

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12 December 2020

Sensitive and rapid assay on MT-4 cells for detection of antiviral compounds against the AIDS virus

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12 December 2020

Overdose of zidovudine

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12 December 2020

Transmission of HIV by antigen presenting cells during T-cell activation: prevention by 3'-azido-3'-deoxythymidine.

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12 December 2020

Inhibitory effect of glycyrrhizin on the in vitro infectivity and cytopathic activity of the human immunodeficiency virus [HIV (HTLV-III/LAV)].

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12 December 2020

The effect of azidothymidine on HIV-related thrombocytopenia

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12 December 2020

3'-Azido-3'-deoxythymidine in feline leukemia virus-infected cats: a model for therapy and prophylaxis of AIDS.

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12 December 2020

Zidovudine-associated myopathy

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12 December 2020

Cryptosporidial diarrhoea in AIDS and its treatment

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12 December 2020

Survival experience among patients with AIDS receiving zidovudine. Follow-up of patients in a compassionate plea program

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12 December 2020

Effect of lithium carbonate on zidovudine-associated neutropenia in the acquired immunodeficiency syndrome

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12 December 2020

Tritiated thymidine incorporation does not measure DNA synthesis in ribavirin-treated human cells.

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12 December 2020

Plasma and cerebrospinal fluid pharmacokinetics of 3'-azido-3'-deoxythymidine: a novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases

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Pyrimidine dideoxyribonucleosides: selectivity of penetration into cerebrospinal fluid

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12 December 2020

Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase

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12 December 2020

Prolonged pancytopenia due to combined ganciclovir and zidovudine therapy

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12 December 2020

Combinations of 3'-azido-3'-deoxythymidine (zidovudine) and phosphonoformate (foscarnet) against human immunodeficiency virus type 1 and cytomegalovirus replication in vitro

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12 December 2020

Isolation of HIV from mononuclear cells of patients receiving zidovudine

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12 December 2020

Nail pigmentation and azidothymidine

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12 December 2020

Broad spectrum antiretroviral activity of 2',3'-dideoxynucleosides

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12 December 2020

The course of the epidemic of acquired immunodeficiency syndrome in the United States hemophilia population

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12 December 2020

Inhibition of the reverse transcriptase from HIV by 3'-azido-3'-deoxythymidine triphosphate and its threo analogue

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12 December 2020

Human immunodeficiency virus (HIV) antigenemia (p24) in the acquired immunodeficiency syndrome (AIDS) and the effect of treatment with zidovudine (AZT).

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12 December 2020

3'-Azido-3'-deoxythymidine inhibits the replication of avian leukosis virus

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12 December 2020

Intravitreous ganciclovir for patients receiving zidovudine

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12 December 2020

Inhibitory effect of 2',3'-didehydro-2',3'-dideoxynucleosides on infectivity, cytopathic effects, and replication of human immunodeficiency virus

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12 December 2020

Zidovudine for lymphocytic interstitial pneumonia associated with AIDS

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12 December 2020

The AIDS dementia complex: I. Clinical features

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12 December 2020

The blood transfusion service and zidovudine treatment for AIDS.

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12 December 2020

Wernicke's encephalopathy in AIDS patient treated with zidovudine

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12 December 2020

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12 December 2020

Administration of 3'-azido-3'-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex

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12 December 2020

Zidovudine-induced hepatotoxicity

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12 December 2020

Effects of zidovudine in 365 consecutive patients with AIDS or AIDS-related complex

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12 December 2020

AIDS encephalopathy with response to treatment

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12 December 2020

Potent and selective activity of 3'-azido-2,6-diaminopurine-2',3'-dideoxyriboside, 3'-fluoro-2,6-diaminopurine-2',3'-dideoxyriboside, and 3'-fluoro-2',3'-dideoxyguanosine against human immunodeficiency virus

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12 December 2020

Clostridium difficile colitis following antiviral therapy in the acquired immunodeficiency syndrome

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12 December 2020

Concurrent zidovudine levels in semen and serum determined by radioimmunoassay in patients with AIDS or AIDS-related complex

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12 December 2020

Profound cytopenia secondary to azidothymidine

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12 December 2020

Synergistic activity of granulocyte-macrophage colony-stimulating factor and 3'-azido-3'-deoxythymidine against human immunodeficiency virus in vitro

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12 December 2020

Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency

1 reference

12 December 2020

Suramin in the treatment of AIDS: mechanism of action

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12 December 2020

Phase I studies of 2',3'-dideoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine (AZT).

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12 December 2020

Zidovudine for the treatment of thrombocytopenia associated with human immunodeficiency virus (HIV). A prospective study. The Swiss Group for Clinical Studies on the Acquired Immunodeficiency Syndrome (AIDS)

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12 December 2020

Results of continued monitoring of participants in the placebo-controlled trial of zidovudine for serious human immunodeficiency virus infection

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12 December 2020

Effect of 3'-azido-2',3'-dideoxythymidine (AZT) and neutralizing antibody on human immunodeficiency virus (HIV)-induced cytopathic effects: implication of giant cell formation for the spread of virus in vivo

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12 December 2020

Thrombocytopenia, the acquired immunodeficiency syndrome (AIDS), and zidovudine

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12 December 2020

Retroviruses and mouse embryos: a rapid model for neurovirulence and transplacental antiviral therapy

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12 December 2020

Increase in intracisternal A-type particles in Friend cells during inhibition of Friend virus (SFFV) release by interferon or azidothymidine

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12 December 2020

Expression of human immunodeficiency virus antigen (HIV-Ag) in serum and cerebrospinal fluid during acute and chronic infection

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12 December 2020

Anti-human immunodeficiency virus agent 3'-azido-3'-deoxythymidine inhibits replication of Epstein-Barr virus

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12 December 2020

The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial

1 reference

12 December 2020

Resumption of HIV antigen production during continuous zidovudine treatment

1 reference

12 December 2020

AIDS-associated psoriasis responds to azidothymidine

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12 December 2020

Effect of zidovudine on serum human immunodeficiency virus antigen levels in symptom-free subjects

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12 December 2020

Effect of continuous intravenous infusion of zidovudine (AZT) in children with symptomatic HIV infection

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12 December 2020

Synergistic inhibition of human immunodeficiency virus in vitro by azidothymidine and recombinant alpha A interferon.

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12 December 2020

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12 December 2020

Can AZT treatment in AIDS patients aggravate pre-existing CMV retinitis?

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12 December 2020

Remission of AIDS-associated psoriasis with zidovudine

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12 December 2020

The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial

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12 December 2020

Antibacterial activity and mechanism of action of 3'-azido-3'-deoxythymidine (BW A509U)

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12 December 2020

Inhibition of hepatitis B virus DNA polymerase by 3'-azido-3'-deoxythymidine triphosphate but not by its threo analog

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12 December 2020

Dextran sulphate, a potent anti-HIV agent in vitro having synergism with zidovudine

1 reference

12 December 2020

Antiviral, antimetabolic and antineoplastic activities of 2'- or 3'-amino or -azido-substituted deoxyribonucleosides

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12 December 2020

Suppression of mouse viraemia and retroviral disease by 3'-azido-3'-deoxythymidine

1 reference

12 December 2020

Inhibition of replication and cytopathic effect of human T cell lymphotropic virus type III/lymphadenopathy-associated virus by 3'-azido-3'-deoxythymidine in vitro

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12 December 2020

Ribavirin antagonizes the effect of azidothymidine on HIV replication

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12 December 2020

Treatment of the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex with a regimen of 3'-azido-2',3'-dideoxythymidine (azidothymidine or zidovudine) and acyclovir. A pilot study

1 reference

12 December 2020

Response of human-immunodeficiency-virus-associated neurological disease to 3'-azido-3'-deoxythymidine

1 reference

12 December 2020

Prophylaxis against Pneumocystis carinii pneumonia in patients receiving azidothymidine

1 reference

12 December 2020

Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate

1 reference

12 December 2020

Zidovudine for lymphocytic interstitial pneumonitis in AIDS

1 reference

12 December 2020

3'-azido-3'-deoxythymidine. An unusual nucleoside analogue that permeates the membrane of human erythrocytes and lymphocytes by nonfacilitated diffusion

1 reference

12 December 2020

Comparative efficacy of broad-spectrum antiviral agents as inhibitors of African swine fever virus replication in vitro

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12 December 2020

Effects of 3'-azido-3'-deoxythymidine on the deoxynucleotide triphosphate pools of cultured human cells

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12 December 2020

In vitro modification of human immunodeficiency virus infection by granulocyte-macrophage colony-stimulating factor and gamma interferon

1 reference

12 December 2020

Azidothymidine neurotoxicity

1 reference

12 December 2020

Different patterns of inhibition of avian myeloblastosis virus reverse transcriptase activity by 3'-azido-3'-deoxythymidine 5'-triphosphate and its threo isomer

1 reference

12 December 2020

Suppression of in vitro haematopoiesis following human immunodeficiency virus infection

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12 December 2020

Survival with the acquired immunodeficiency syndrome. Experience with 5833 cases in New York City

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12 December 2020

Resumption of virus production after human immunodeficiency virus infection of T lymphocytes in the presence of azidothymidine

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12 December 2020

Azidothymidine associated with bone marrow failure in the acquired immunodeficiency syndrome (AIDS)

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12 December 2020

Long-term administration of 3'-azido-2',3'-dideoxythymidine to patients with AIDS-related neurological disease

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12 December 2020

Strategies for antiviral therapy in AIDS.

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12 December 2020

Preclinical toxicology of zidovudine. An overview.

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12 December 2020

The biology of the immune response

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12 December 2020

Resolution of resistant chronic herpetic lesions with zidovudine in a patient with the acquired immunodeficiency syndrome.

1 reference

12 December 2020

3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro

1 reference

12 December 2020

Zidovudine overdosage

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12 December 2020

Nail pigmentation changes associated with azidothymidine (zidovudine)

1 reference

12 December 2020

Detection, Isolation, and Continuous Production of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and Pre-AIDS

1 reference

12 December 2020

10.2165/00003495-198937040-00003

Identifiers

DOI

1 reference

PubMed ID

2661194

Dimensions Publication ID

5 September 2017

0 references

1 reference

PubMed ID

2661194