Dysregulated Chemokine Signaling in Cystic Fibrosis Lung Disease: A Potential Therapeutic Target. (Q38663113)

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2 March 2020

title

Dysregulated Chemokine Signaling in Cystic Fibrosis Lung Disease: A Potential Therapeutic Target (English)

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2 March 2020

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Xiaoqing Guan

1

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2 March 2020

Yuning Hou

2

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2 March 2020

Fei Sun

3

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2 March 2020

Zhe Yang

4

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2 March 2020

Chunying Li

5

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2 March 2020

publication date

1 January 2016

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2 March 2020

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2 March 2020

volume

17

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2 March 2020

page(s)

1535-1544

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2 March 2020

issue

13

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Abnormal glutathione transport in cystic fibrosis airway epithelia

2 March 2020

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Cytokines and inflammatory mediators in cystic fibrosis.

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Chronic airway infection/inflammation induces a Ca2+i-dependent hyperinflammatory response in human cystic fibrosis airway epithelia

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Calcium-dependent regulation of NF-(kappa)B activation in cystic fibrosis airway epithelial cells

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Lysophosphatidic acid inhibits cholera toxin-induced secretory diarrhea through CFTR-dependent protein interactions

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Lower airway inflammation in infants with cystic fibrosis detected by newborn screening.

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CFTR inhibition mimics the cystic fibrosis inflammatory profile

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A morphometric study of mucins and small airway plugging in cystic fibrosis.

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IL-1 beta stimulates divergent upper and lower airway epithelial cell CCL5 secretion.

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MPB-07 Reduces the Inflammatory Response toPseudomonas aeruginosain Cystic Fibrosis Bronchial Cells

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Enhanced IL-1beta-induced IL-8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen-activated protein kinases and NF-kappaB signaling

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Calcium homeostasis is abnormal in cystic fibrosis airway epithelial cells but is normalized after rescue of F508del-CFTR.

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Loss of cystic fibrosis transmembrane conductance regulator function enhances activation of p38 and ERK MAPKs, increasing interleukin-6 synthesis in airway epithelial cells exposed to Pseudomonas aeruginosa

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Use of bioluminescence imaging to track neutrophil migration and its inhibition in experimental colitis.

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P. aeruginosa drives CXCL8 synthesis via redundant toll-like receptors and NADPH oxidase in CFTR∆F508 airway epithelial cells.

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The airway epithelium: soldier in the fight against respiratory viruses

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Elevated miR-155 promotes inflammation in cystic fibrosis by driving hyperexpression of interleukin-8

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12 December 2020

Cystic fibrosis and the innate immune system: therapeutic implications

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Infection, inflammation, and lung function decline in infants with cystic fibrosis.

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Enhanced Ca2+ entry due to Orai1 plasma membrane insertion increases IL-8 secretion by cystic fibrosis airways

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12 December 2020

F508del-CFTR increases intracellular Ca(2+) signaling that causes enhanced calcium-dependent Cl(-) conductance in cystic fibrosis

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12 December 2020

Neutrophil extracellular trap (NET)-mediated killing of Pseudomonas aeruginosa: evidence of acquired resistance within the CF airway, independent of CFTR.

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12 December 2020

CFTR negatively regulates cyclooxygenase-2-PGE(2) positive feedback loop in inflammation

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12 December 2020

Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in cystic fibrosis cells

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12 December 2020

Ultrastructural characterization of cystic fibrosis sputum using atomic force and scanning electron microscopy

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12 December 2020

Mapping the transcriptional machinery of the IL-8 gene in human bronchial epithelial cells.

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Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines

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Effect of azithromycin on systemic markers of inflammation in patients with cystic fibrosis uninfected with Pseudomonas aeruginosa.

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Innate immunity in cystic fibrosis lung disease

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Safety and early treatment effects of the CXCR2 antagonist SB-656933 in patients with cystic fibrosis

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Expression of the nuclear factor-κB inhibitor A20 is altered in the cystic fibrosis epithelium

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12 December 2020

Cystic fibrosis transmembrane conductance regulator recruitment to phagosomes in neutrophils

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12 December 2020

Epithelial uptake of flagella initiates proinflammatory signaling.

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12 December 2020

Effect of VX-770 (ivacaftor) and OAG on Ca2+ influx and CFTR activity in G551D and F508del-CFTR expressing cells.

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12 December 2020

High expression of midkine in the airways of patients with cystic fibrosis

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12 December 2020

Adult-specific functions of animal microRNAs

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A novel Pseudomonas aeruginosa-derived effector cooperates with flagella to mediate the upregulation of interleukin 8 in human epithelial cells.

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The protein kinases TPL2 and EGFR contribute to ERK1/ERK2 hyper-activation in CFTRΔF508-expressing airway epithelial cells exposed to Pseudomonas aeruginosa

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The low PLC-δ1 expression in cystic fibrosis bronchial epithelial cells induces upregulation of TRPV6 channel activity.

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Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils

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The behaviour of the keratinizing epithelium in tympanoplasty

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12 December 2020

Molecular mechanism of interleukin-8 gene expression

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12 December 2020

Cytokines in neutrophil-dominated airway inflammation in patients with cystic fibrosis

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12 December 2020

Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is downregulated in cystic fibrosis

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12 December 2020

Up-regulation of monocytic IL-10 by tumor necrosis factor-alpha and cAMP elevating drugs

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12 December 2020

Diverse Pseudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8

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12 December 2020

IL-8 induces neutrophil chemotaxis predominantly via type I IL-8 receptors

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12 December 2020

Cystic fibrosis gene and protein expression during fetal lung development.

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12 December 2020

Early pulmonary inflammation in infants with cystic fibrosis

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12 December 2020

Cleavage of lymphocyte surface antigens CD2, CD4, and CD8 by polymorphonuclear leukocyte elastase and cathepsin G in patients with cystic fibrosis

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12 December 2020

Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression.

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12 December 2020

Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8

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12 December 2020

Regulation of interleukin 8 gene expression by oxidant stress

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12 December 2020

Predominant role of tumor necrosis factor-alpha in human monocyte IL-10 synthesis

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12 December 2020

Inflammatory cytokines in cystic fibrosis lungs

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12 December 2020

The relationship between infection and inflammation in the early stages of lung disease from cystic fibrosis

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12 December 2020

Osmotic regulation of cytokine synthesis in vitro

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12 December 2020

A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism

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12 December 2020

The NF-kappa B and I kappa B proteins: new discoveries and insights

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12 December 2020

Disturbed myeloperoxidase-dependent activity of neutrophils in cystic fibrosis homozygotes and heterozygotes, and its correction by amiloride

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12 December 2020

Role of unphosphorylated, newly synthesized I kappa B beta in persistent activation of NF-kappa B

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12 December 2020

Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade

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12 December 2020

Oct-1 and CCAAT/enhancer-binding protein (C/EBP) bind to overlapping elements within the interleukin-8 promoter. The role of Oct-1 as a transcriptional repressor

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12 December 2020

The role of nuclear factor-kappa B in cytokine gene regulation

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12 December 2020

Mechanisms involved in Helicobacter pylori-induced interleukin-8 production by a gastric cancer cell line, MKN45.

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Identification of tumor-specific paclitaxel (Taxol)-responsive regulatory elements in the interleukin-8 promoter

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Lower airway inflammation in infants and young children with cystic fibrosis.

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A promoter recruitment mechanism for tumor necrosis factor-alpha-induced interleukin-8 transcription in type II pulmonary epithelial cells. Dependence on nuclear abundance of Rel A, NF-kappaB1, and c-Rel transcription factors

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12 December 2020

Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration

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12 December 2020

Activator protein-1 is the preferred transcription factor for cooperative interaction with nuclear factor-kappaB in respiratory syncytial virus-induced interleukin-8 gene expression in airway epithelium

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12 December 2020

Rapid secretion of prestored interleukin 8 from Weibel-Palade bodies of microvascular endothelial cells

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12 December 2020

Endothelial cell "memory" of inflammatory stimulation: human venular endothelial cells store interleukin 8 in Weibel-Palade bodies

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12 December 2020

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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12 December 2020

Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins

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12 December 2020

10.2174/1389450117666151209120516

Identifiers

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