HIV-1 Eradication: Early Trials (and Tribulations). (Q38675631)

15 June 2018

title

HIV-1 Eradication: Early Trials (and Tribulations). (English)

1 reference

15 June 2018

Adam M Spivak

1

0 references

author name string

Vicente Planelles

series ordinal

2

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15 June 2018

publication date

12 December 2015

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15 June 2018

Trends in Molecular Medicine

published in

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15 June 2018

volume

22

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15 June 2018

issue

1

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15 June 2018

page(s)

10-27

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15 June 2018

A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals

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The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo

23 June 2018

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Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation

23 June 2018

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An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression

23 June 2018

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Ex Vivo Bioactivity and HIV-1 Latency Reversal by Ingenol Dibenzoate and Panobinostat in Resting CD4(+) T Cells from Aviremic Patients

23 June 2018

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The Tat Inhibitor Didehydro-Cortistatin A Prevents HIV-1 Reactivation from Latency

23 June 2018

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Panobinostat: a novel pan-deacetylase inhibitor for the treatment of relapsed or relapsed and refractory multiple myeloma

23 June 2018

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HIV Excision Utilizing CRISPR/Cas9 Technology: Attacking the Proviral Quasispecies in Reservoirs to Achieve a Cure

23 June 2018

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Precise Quantitation of the Latent HIV-1 Reservoir: Implications for Eradication Strategies

23 June 2018

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The need for treatment interruption studies and biomarker identification in the search for an HIV cure.

23 June 2018

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Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations.

23 June 2018

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Evidence of long-term disease control with panobinostat maintenance in patients with relapsed multiple myeloma.

23 June 2018

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Towards an HIV-1 cure: measuring the latent reservoir

23 June 2018

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Viremic relapse after HIV-1 remission in a perinatally infected child

23 June 2018

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Studies of retroviral infection in humanized mice

23 June 2018

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Bioinformatics and HIV latency

23 June 2018

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Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy

23 June 2018

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Persistence of virus reservoirs in ART-treated SHIV-infected rhesus macaques after autologous hematopoietic stem cell transplant

23 June 2018

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Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1

23 June 2018

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Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation: report of 2 cases

23 June 2018

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Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing

23 June 2018

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New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo.

23 June 2018

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HIV-1 expression within resting CD4+ T cells after multiple doses of vorinostat

23 June 2018

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Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV

23 June 2018

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Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure

23 June 2018

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An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients

23 June 2018

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A pilot study assessing the safety and latency-reversing activity of disulfiram in HIV-1-infected adults on antiretroviral therapy

23 June 2018

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The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time

23 June 2018

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An integrated overview of HIV-1 latency

23 June 2018

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HIV-1 infection, response to treatment and establishment of viral latency in a novel humanized T cell-only mouse (TOM) model

23 June 2018

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Absence of detectable HIV-1 viremia after treatment cessation in an infant

23 June 2018

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HIV-1 transcription and latency: an update

23 June 2018

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Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay

23 June 2018

1 reference

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Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study

23 June 2018

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Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation

23 June 2018

1 reference

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Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889129

Comparison of HDAC inhibitors in clinical development: effect on HIV production in latently infected cells and T-cell activation

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889129

Targeting HIV latency: pharmacologic strategies toward eradication

23 June 2018

1 reference

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Redefining the viral reservoirs that prevent HIV-1 eradication

23 June 2018

1 reference

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Developing strategies for HIV-1 eradication

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889129

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889129

An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889129

Towards an HIV cure: a global scientific strategy

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889129

Disulfiram reactivates latent HIV-1 expression through depletion of the phosphatase and tensin homolog

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889129

Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889129

No effect of raltegravir intensification on viral replication markers in the blood of HIV-1-infected patients receiving antiretroviral therapy

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889129

HIV latency in the humanized BLT mouse

23 June 2018

1 reference

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Generation of HIV latency in humanized BLT mice

23 June 2018

1 reference

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Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation

23 June 2018

1 reference

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Chemokine receptor 5 knockout strategies

23 June 2018

1 reference

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Curing HIV: Pharmacologic approaches to target HIV-1 latency

23 June 2018

1 reference

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Patients on HAART often have an excess of unintegrated HIV DNA: implications for monitoring reservoirs

23 June 2018

1 reference

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Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication

23 June 2018

1 reference

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Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy

23 June 2018

1 reference

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Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction

23 June 2018

1 reference

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Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4+ cell infection

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889129

Short-course raltegravir intensification does not reduce persistent low-level viremia in patients with HIV-1 suppression during receipt of combination antiretroviral therapy

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889129

Stochastic gene expression as a molecular switch for viral latency

23 June 2018

1 reference

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A simian immunodeficiency virus-infected macaque model to study viral reservoirs that persist during highly active antiretroviral therapy

23 June 2018

1 reference

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Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889129

The challenge of finding a cure for HIV infection

23 June 2018

1 reference

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Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation

23 June 2018

1 reference

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HIV-1 viral rebound dynamics after a single treatment interruption depends on time of initiation of highly active antiretroviral therapy

23 June 2018

1 reference

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Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells

23 June 2018

1 reference

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CD4+ count-guided interruption of antiretroviral treatment

23 June 2018

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Depletion of latent HIV-1 infection in vivo: a proof-of-concept study

23 June 2018

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Limited durability of viral control following treated acute HIV infection

23 June 2018

1 reference

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Predictors of Plasma Human Immunodeficiency Virus Type 1 RNA Control after Discontinuation of Highly Active Antiretroviral Therapy Initiated at Acute Infection Combined with Structured Treatment Interruptions and Immune‐Based Therapies

23 June 2018

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New real-time reverse transcriptase-initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma

23 June 2018

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Analysis of human immunodeficiency virus type 1 gene expression in latently infected resting CD4+ T lymphocytes in vivo

23 June 2018

1 reference

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A sensitive, quantitative assay for human immunodeficiency virus type 1 integration

23 June 2018

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Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies

23 June 2018

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Pilot study of a combination of highly active antiretroviral therapy and cytokines to induce HIV-1 remission

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889129

HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression

23 June 2018

1 reference

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Immuno-activation with anti-CD3 and recombinant human IL-2 in HIV-1-infected patients on potent antiretroviral therapy

23 June 2018

1 reference

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Changing patterns of mortality across Europe in patients infected with HIV-1. EuroSIDA Study Group.

23 June 2018

1 reference

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Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators

23 June 2018

1 reference

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Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy

23 June 2018

1 reference

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Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy

23 June 2018

1 reference

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Recovery of replication-competent HIV despite prolonged suppression of plasma viremia

23 June 2018

1 reference

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A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team

23 June 2018

1 reference

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Decay characteristics of HIV-1-infected compartments during combination therapy

23 June 2018

1 reference

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Accumulation of defective viral genomes in peripheral blood mononuclear cells of human immunodeficiency virus type 1-infected individuals.

23 June 2018

1 reference

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Prognosis in HIV-1 infection predicted by the quantity of virus in plasma

23 June 2018

1 reference

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Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

23 June 2018

1 reference

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HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure

23 June 2018

1 reference

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The Remarkable Stability of the Latent Reservoir for HIV-1 in Resting Memory CD4+ T Cells.

23 June 2018

1 reference

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Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure.

31 August 2018

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31 August 2018

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Prolonged valproic acid treatment does not reduce the size of latent HIV reservoir

31 August 2018

1 reference

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Stability of the latent reservoir for HIV-1 in patients receiving valproic acid

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889129

Valproic acid: a potential role in treating latent HIV infection

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889129

Intermittent HIV-1 viremia (Blips) and drug resistance in patients receiving HAART.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889129

Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889129

Intensification and stimulation therapy for human immunodeficiency virus type 1 reservoirs in infected persons receiving virally suppressive highly active antiretroviral therapy

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889129

Effects of interleukin-2 plus highly active antiretroviral therapy on HIV-1 replication and proviral DNA (COSMIC trial).

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889129

Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5889129

Can we avoid treatment interruption studies in the search for an HIV cure?

31 August 2018

1 reference

12 December 2020

Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy

1 reference

12 December 2020

No cure yet for HIV-1, but therapeutic research presses on

1 reference

12 December 2020

Quantitation of HIV-1 RNA in plasma predicts outcome after seroconversion

1 reference

12 December 2020

Reversible neurotoxicity during interleukin-2 therapy for metastatic renal cell carcinoma

1 reference

12 December 2020

Proviral HIV-DNA predicts viral rebound and viral setpoint after structured treatment interruptions

1 reference

12 December 2020

Phase IB clinical trial of anti-CD3 followed by high-dose bolus interleukin-2 in patients with metastatic melanoma and advanced renal cell carcinoma: clinical and immunologic effects

1 reference

12 December 2020

10.1016/J.MOLMED.2015.11.004

Identifiers

DOI

1 reference

15 June 2018

PMCID

5889129

1 reference

15 June 2018

PubMed ID

26691297

1 reference

15 June 2018