The tumor suppressor hamartin enhances Dbl protein transforming activity through interaction with ezrin. (Q38676485)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21712385%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

The tumor suppressor hamartin enhances Dbl protein transforming activity through interaction with ezrin (English)

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6 February 2020

3

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6 February 2020

Patrizia Mancini

4

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6 February 2020

Maria Carla Bosco

7

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6 February 2020

Alessandra Eva

9

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6 February 2020

author name string

Marzia Ognibene

1

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6 February 2020

Cristina Vanni

2

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6 February 2020

Elisa Merello

5

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6 February 2020

Maria Rosaria Torrisi

6

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6 February 2020

Luigi Varesio

8

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6 February 2020

language of work or name

English

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publication date

28 June 2011

1 reference

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Journal of Biological Chemistry

6 February 2020

published in

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6 February 2020

volume

286

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6 February 2020

issue

34

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6 February 2020

page(s)

29973-29983

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Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.

6 February 2020

cites work

1 reference

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Organizing the cell cortex: the role of ERM proteins

6 September 2017

1 reference

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Spatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scattering

6 September 2017

1 reference

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Immune synapse formation requires ZAP-70 recruitment by ezrin and CD43 removal by moesin

6 September 2017

1 reference

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Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin

6 September 2017

1 reference

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Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells

6 September 2017

1 reference

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ERM proteins in epithelial cell organization and functions

6 September 2017

1 reference

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Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine

6 September 2017

1 reference

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Ezrin regulates E-cadherin-dependent adherens junction assembly through Rac1 activation

6 September 2017

1 reference

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ERM proteins and merlin: integrators at the cell cortex

6 September 2017

1 reference

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Regulation of proto-Dbl by intracellular membrane targeting and protein stability

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Mutagenesis of the phosphatidylinositol 4,5-bisphosphate (PIP(2)) binding site in the NH(2)-terminal domain of ezrin correlates with its altered cellular distribution

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Regulatory and signaling properties of the Vav family

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Regulation of F-actin binding to platelet moesin in vitro by both phosphorylation of threonine 558 and polyphosphatidylinositides

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Recruitment of Dbl by ezrin and dystroglycan drives membrane proximal Cdc42 activation and filopodia formation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Ezrin directly interacts with the alpha1b-adrenergic receptor and plays a role in receptor recycling

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation.

14 September 2017

1 reference

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Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes

14 September 2017

1 reference

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Parallel signal processing among mammalian MAPKs

14 September 2017

1 reference

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Stimulation of phosphatidylinositol-4-phosphate 5-kinase by Rho-kinase.

14 September 2017

1 reference

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Involvement of NH(2)-terminal sequences in the negative regulation of Vav signaling and transforming activity

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Specific involvement of G proteins in regulation of serum response factor-mediated gene transcription by different receptors

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Phosphorylation of 558T of moesin detected by site-specific antibodies in RAW264.7 macrophages

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Inhibition of PI3K induces Rac activation and membrane ruffling in proto-Dbl expressing cells

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Phosphorylation-independent membrane relocalization of ezrin following association with Dbl in vivo

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Activation of the PKB/AKT pathway by ICAM-2.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Modulation of oncogenic DBL activity by phosphoinositol phosphate binding to pleckstrin homology domain.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinases

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Galpha13 regulation of proto-Dbl signaling

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Activation of p38 has opposing effects on the proliferation and migration of endothelial cells

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Ezrin interacts with focal adhesion kinase and induces its activation independently of cell-matrix adhesion

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Immunofluorescence detection of ezrin/radixin/moesin (ERM) proteins with their carboxyl-terminal threonine phosphorylated in cultured cells and tissues

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191038

Phosphorylation of moesin by rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structures

31 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21712385

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identification of a phosphatidylinositol-4,5-bisphosphate-binding domain in the N-terminal region of ezrin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21712385

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M111.270785

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21712385%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21712385%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

21712385

1 reference