Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer (Q38705362)

3 November 2017

Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer (English)

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3 November 2017

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13

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PubMed publication ID

5 September 2017

Kevin P O'Rourke

1

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3 November 2017

Evangelia Loizou

2

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3 November 2017

Geulah Livshits

3

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3 November 2017

Emma M Schatoff

4

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3 November 2017

Timour Baslan

5

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3 November 2017

Eusebio Manchado

6

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3 November 2017

Janelle Simon

7

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3 November 2017

Paul B Romesser

8

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3 November 2017

Benjamin Leach

9

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3 November 2017

Teng Han

10

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3 November 2017

Chantal Pauli

11

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3 November 2017

Himisha Beltran

12

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3 November 2017

Lukas E Dow

14

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3 November 2017

Scott W Lowe

15

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3 November 2017

1 May 2017

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3 November 2017

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3 November 2017

35

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3 November 2017

6

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3 November 2017

577-582

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Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research

3 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462850

Animal models of colorectal cancer with liver metastasis

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462850

Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462850

Prospective derivation of a living organoid biobank of colorectal cancer patients.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462850

Optimizing sparse sequencing of single cells for highly multiplex copy number profiling

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462850

Inducible in vivo genome editing with CRISPR-Cas9

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462850

Comparative sequencing analysis reveals high genomic concordance between matched primary and metastatic colorectal cancer lesions

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462850

Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462850

Genome-scale CRISPR-Cas9 knockout screening in human cells

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462850

Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462850

Genetic reconstitution of tumorigenesis in primary intestinal cells

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462850

Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462850

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462850

Controlled gene expression in primary Lgr5 organoid cultures

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462850

Generation of a transgenic mouse for colorectal cancer research with intestinal cre expression limited to the large intestine

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462850

Molecular origins of cancer: Molecular basis of colorectal cancer

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462850

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462850

Mouse models of colon cancer

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462850

Suppression of non-small cell lung tumor development by the let-7 microRNA family

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462850

Mouse models of colorectal cancer and liver metastases

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462850

Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462850

A genetic model for colorectal tumorigenesis

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462850

Sequential cancer mutations in cultured human intestinal stem cells.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462850

Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462850

Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation

31 August 2018

1 reference

7 January 2021

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

1 reference

7 January 2021

SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion

1 reference

7 January 2021

In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

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7 January 2021

Identifiers

DOI

10.1038/NBT.3837

1 reference

3 November 2017

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3 November 2017

PubMed publication ID

28459450

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