Novel biochemical pathways in parasitic protozoa (Q38715992)

5 September 2017

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title

Novel biochemical pathways in parasitic protozoa (English)

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5 September 2017

Fairlamb AH

1

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publication date

1 January 1989

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5 September 2017

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5 September 2017

99 Suppl

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5 September 2017

S93-112

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Energy metabolism of protozoa without mitochondria

5 September 2017

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

The phosphoglycerate kinases from Trypanosoma brucei. A comparison of the glycosomal and the cytosolic isoenzymes and their sensitivity towards suramin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

In vitro activities of and mechanisms of resistance to antifol antimalarial drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

The biochemistry and functional morphology of the Entamoeba

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Subcellular localisation of purine-metabolising enzymes in Leishmania mexicana mexicana.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Atomic structure of thymidylate synthase: target for rational drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Purine and pyrimidine metabolism in the Trypanosomatidae

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Inhibition of pyrimidine biosynthesis de novo in Plasmodium falciparum by 2-(4-t-butylcyclohexyl)-3-hydroxy-1,4-naphthoquinone in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Conversion of dihydroorotate to orotate in parasitic protozoa

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania tropica: sequence homology with the corresponding monofunctional proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

p-Alkyloxybenzhydroxamic acids, effective inhibitors of the trypanosome glycerol-3-phosphate oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Esters of 3,4-dihydroxybenzoic acid, highly effective inhibitors of the sn-glycerol-3-phosphate oxidase of Trypanosoma brucei brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Polyamine depletion following exposure to DL-alpha-difluoromethylornithine both in vivo and in vitro initiates morphological alterations and mitochondrial activation in a monomorphic strain of Trypanosoma brucei brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Mitochondrial DNA of the human malarial parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

New approach to screening drugs for activity against African trypanosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Trypanothione is the primary target for arsenical drugs against African trypanosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

The biosynthesis of trypanothione and N1-glutathionylspermidine in Crithidia fasciculata.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Identification of a novel, thiol-containing co-factor essential for glutathione reductase enzyme activity in trypanosomatids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Uptake of the trypanocidal drug suramin by bloodstream forms of Trypanosoma brucei and its effect on respiration and growth rate in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Mouse glucose-6-phosphate isomerase and neuroleukin have identical 3' sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Entamoeba histolytica: a eukaryote without glutathione metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Lens proteins. More molecular opportunism

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Products of Leishmania braziliensis glucose catabolism: release of D-lactate and, under anaerobic conditions, glycerol

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

D-lactate production by Leishmania braziliensis through the glyoxalase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Dihydrolipoamide dehydrogenase from Trypanosoma brucei. Characterization and cellular location

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Trypanosomiasis: an approach to chemotherapy by the inhibition of carbohydrate catabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

The neurotrophic factor neuroleukin is 90% homologous with phosphohexose isomerase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Aldolase activity of a Plasmodium falciparum protein with protective properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

In vivo time course of synthesis and processing of major schizont membrane polypeptides in Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

The metabolism of Plasmodium berghei, the malaria parasite of rodents. I. The preparation of the erythrocytic form of P. berghei separated from the host cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Effects of alpha-difluoromethylornithine on protein synthesis and synthesis of the variant-specific glycoprotein (VSG) in Trypanosoma brucei brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Primary structure of the gene encoding the bifunctional dihydrofolate reductase-thymidylate synthase of Leishmania major

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Insights into enzyme function from studies on mutants of dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Biochemical changes associated with alpha-difluoromethylornithine uptake and resistance in Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Identification of two integral glycosomal membrane proteins in Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Absence of substrate channeling in the glycosome of Trypanosoma brucei.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Pyrimidine metabolism in Tritrichomonas foetus

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Parasite enzymes as potential targets for antiparasitic chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Effects of various metabolic conditions and of the trivalent arsenical melarsen oxide on the intracellular levels of fructose 2,6-bisphosphate and of glycolytic intermediates in Trypanosoma brucei.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Anaerobic pyruvate metabolism of Tritrichomonas foetus and Trichomonas vaginalis hydrogenosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Glycerol, a metabolic end product of Trichomonas vaginalis and Tritrichomonas foetus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Mr 26,000 antigen of Schistosoma japonicum recognized by resistant WEHI 129/J mice is a parasite glutathione S-transferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

DL-alpha-difluoromethyl[3,4-3H]arginine metabolism in tobacco and mammalian cells. Inhibition of ornithine decarboxylase activity after arginase-mediated hydrolysis of DL-alpha-difluoromethylarginine to DL-alpha-difluoromethylornithine

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Trypanothione reductase of Trypanosoma congolense: gene isolation, primary sequence determination, and comparison to glutathione reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Plasmodium berghei: glycolytic intermediate concentrations of the infected mouse erythrocyte.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Enzymes of purine and pyrimidine metabolism from the human malaria parasite, Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Antitrypanosomal Effect of Allopurinol: Conversion in Vivo to Aminopyrazolopyrimidine Nucleotides by Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Pyrazolopyrimidine metabolism in the pathogenic trypanosomatidae

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Antileishmanial action of 4-thiopyrazolo (3.4-d) pyrimidine and its ribonucleoside. Biological effects and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Characterization of the genes for fructose-bisphosphate aldolase in Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Purification and properties of NADPH:flavin oxidoreductase from Entamoeba histolytica

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Metabolism and mechanism of action of formycin B in Leishmania

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Properties and substrate specificity of a purine phosphoribosyltransferase from the human malaria parasite, Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Immunization with a Plasmodium falciparum merozoite surface antigen induces a partial immunity in monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

In vitro activity of sulfonamides and sulfones against Leishmania major promastigotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

The purification and properties of two soluble reduced nicotinamide: acceptor oxidoreductases from Trichomonas vaginalis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

De novo and salvage biosynthesis of pteroylpentaglutamates in the human malaria parasite, Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Plasmodium berghei: glycolytic enzymes of the infected mouse erythrocyte.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Characterisation of cDNA clones for hypoxanthine-guanine phosphoribosyltransferase from the human malarial parasite, Plasmodium falciparum: comparisons to the mammalian gene and protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Polyamine metabolism in Acanthamoeba: polyamine content and synthesis of ornithine, putrescine, and diaminopropane

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Arginine decarboxylase inhibitors reduce the capacity of Trypanosoma cruzi to infect and multiply in mammalian host cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Purification, morphometric analysis, and characterization of the glycosomes (microbodies) of the protozoan hemoflagellate Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Glycosomes may provide clues to the import of peroxisomal proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Compartmentation of carbohydrate metabolism in trypanosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Chemotherapy of trypanosomiasis: the potentiation of melarsoprol by concurrent difluoromethylornithine (DFMO) treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Nucleotide sequence analysis of an Entamoeba histolytica ferredoxin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

A freeze-fracture electron microscope study of Trichomonas vaginalis Donné and Tritrichomonas foetus (Riedmüller).

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

The potential use of inhibitors of glycerol-3-phosphate oxidase for chemotherapy of African trypanosomiasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Localization of nine glycolytic enzymes in a microbody-like organelle in Trypanosoma brucei : The glycosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

"Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Trypanothione metabolism: a chemotherapeutic target in trypanosomatids

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Glycolytic enzymes of Trypanosoma brucei. Simultaneous purification, intraglycosomal concentrations and physical properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Simultaneous purification of hexokinase, class-I fructose-bisphosphate aldolase, triosephosphate isomerase and phosphoglycerate kinase from Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Trypanothione dependent peroxide metabolism in Crithidia fasciculata and Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

A novel location for two enzymes of de novo pyrimidine biosynthesis in trypanosomes and Leishmania

21 January 2018

2 references

https://api.crossref.org/works/10.1017%2FS003118200008344X

21 January 2018

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Subcellular Compartmentation of Glycolytic Intermediates in Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Stimulation of Trypanosoma brucei pyruvate kinase by fructose 2,6-bisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Substrate specificity of the flavoprotein trypanothione disulfide reductase from Crithidia fasciculata

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

Purine and pyrimidine metabolizing activities in Trichomonas vaginalis extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

Studies on the glycosomal orotate phosphoribosyl transferase of Trypanosoma cruzi

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

UMP synthesis in the kinetoplastida

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

Studies on glycerol kinase and its role in ATP synthesis in Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

Inhibition of Growth ofGiardia lambliaby Difluoromethylornithine, a Specific Inhibitor of Polyamine Biosynthesis1

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

The role of threonine in the metabolism of acetyl coenzyme a by Trypanosoma brucei brucei

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

A bifunctional thymidylate synthetase-dihydrofolate reductase in protozoa

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

The action of trypanocidal arsenical drugs on Trypanosoma brucei and Trypanosoma rhodesiense

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

The interaction in vitro between bovine immunoglobulin and juvenile Fasciola hepatica.

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

Mechanisms of sulfadoxine resistance in Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

A comparative study of D-lactate, L-lactate and glycerol formation by four species of Leishmania and by Trypanosoma lewisi and Trypanosoma brucei gambiense

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

13C-NMR reveals glycerol as an unexpected major metabolite of the protozoan parasite Trichomonas vaginalis

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

Phosphorylation and anti-leishmanial activity of formycin B

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

Occurrence and role of phosphoenolpyruvate carboxykinase in procyclic Trypanosoma brucei brucei glycosomes

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

Fine structure and cytochemistry of the hydrogenosome of Tritrichomonas foetus

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

Effect of DL-alpha-difluoromethylornithine on polyamine synthesis and interconversion in Trichomonas vaginalis grown in a semi-defined medium

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

Entamoeba histolytica. I. Aerobic metabolism

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

The glutathione transferase activity and tissue distribution of a cloned Mr28K protective antigen of Schistosoma mansoni.

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

The topogenic signal of the glycosomal (microbody) phosphoglycerate kinase of Crithidia fasciculata resides in a carboxy-terminal extension

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

Folic acid metabolism

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

Entamoeba histolytica: Isolation of ferredoxin

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

The pathway of arginine catabolism in the parasitic flagellate Trichomonas vaginalis

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

Metabolism of Entamoeba histolytica Schaudinn, 1903

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

Polyamines in Acanthamoeba castellanii: presence of an unusually high, osmotically sensitive pool of 1,3-diaminopropane

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

Trypanosomatid hydrogen peroxide [corrected] metabolism

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

Purification and properties of dihydroorotate oxidase from Crithidia fasciculata and Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

Trypanosoma brucei: preparation and some properties of a multienzyme complex catalysing part of the glycolytic pathway

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

Novel anti-malarial hydroxynaphthoquinones with potent broad spectrum anti-protozoal activity

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

Proteins responsible for a punctate fluorescence pattern in Plasmodium falciparum merozoites

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

Purine metabolism in Trichomonas vaginalis

1 reference

https://api.crossref.org/works/10.1017%2FS003118200008344X

7 January 2021

10.1017/S003118200008344X

Identifiers

DOI

1 reference

5 September 2017

1 reference

PubMed ID

2682488