Free-fatty acid receptor-4 (GPR120): Cellular and molecular function and its role in metabolic disorders. (Q38717207)

5 September 2017

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title

Free-fatty acid receptor-4 (GPR120): Cellular and molecular function and its role in metabolic disorders (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6415295&resulttype=core&format=json

13 May 2020

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Nader H Moniri

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6415295&resulttype=core&format=json

13 May 2020

language of work or name

English

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publication date

28 January 2016

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5 September 2017

Biochemical Pharmacology

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6415295&resulttype=core&format=json

13 May 2020

volume

110-111

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6415295&resulttype=core&format=json

13 May 2020

page(s)

1-15

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6415295&resulttype=core&format=json

Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization

13 May 2020

cites work

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12 December 2020

Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives

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12 December 2020

Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120

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12 December 2020

Transduction of receptor signals by beta-arrestins

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12 December 2020

beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor

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12 December 2020

Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules

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12 December 2020

Protein kinase Czeta is required for oleic acid-induced secretion of glucagon-like peptide-1 by intestinal endocrine L cells

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12 December 2020

The regulation of adipogenesis through GPR120.

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12 December 2020

GPR expression in the rat taste bud relating to fatty acid sensing.

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12 December 2020

Free fatty acids induce cholecystokinin secretion through GPR120.

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12 December 2020

Modulation of osteoclastogenesis by fatty acids

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12 December 2020

Identification of G protein-coupled receptor 120-selective agonists derived from PPARgamma agonists.

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12 December 2020

Colocalization of GPR120 with phospholipase-Cbeta2 and alpha-gustducin in the taste bud cells in mice.

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12 December 2020

Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells

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12 December 2020

Distribution and regulation of protein expression of the free fatty acid receptor GPR120.

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12 December 2020

Novel selective ligands for free fatty acid receptors GPR120 and GPR40.

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12 December 2020

Cloning, expression, and pharmacological characterization of the GPR120 free fatty acid receptor from cynomolgus monkey: comparison with human GPR120 splice variants

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12 December 2020

Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor

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12 December 2020

Taste Preference for Fatty Acids Is Mediated by GPR40 and GPR120

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12 December 2020

GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects

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12 December 2020

Processing of proglucagon to GLP-1 in pancreatic α-cells: is this a paracrine mechanism enabling GLP-1 to act on β-cells?

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12 December 2020

Unsaturated fatty acids stimulate LH secretion via novel PKCepsilon and -theta in gonadotrope cells and inhibit GnRH-induced LH release

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12 December 2020

G protein-coupled receptors in human fat taste perception

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12 December 2020

The lipid-sensor candidates CD36 and GPR120 are differentially regulated by dietary lipids in mouse taste buds: impact on spontaneous fat preference

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12 December 2020

Altered expression of gustatory-signaling elements in gastric tissue of morbidly obese patients

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12 December 2020

Diet-induced obesity up-regulates the abundance of GPR43 and GPR120 in a tissue specific manner

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12 December 2020

Differential signaling by splice variants of the human free fatty acid receptor GPR120.

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12 December 2020

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

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12 December 2020

Discovery of a potent and selective GPR120 agonist.

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12 December 2020

Decreased intestinal nutrient response in diet-induced obese rats: role of gut peptides and nutrient receptors

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12 December 2020

Postprandial inhibition of gastric ghrelin secretion by long-chain fatty acid through GPR120 in isolated gastric ghrelin cells and mice

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12 December 2020

Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein

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12 December 2020

A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets

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12 December 2020

Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity

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12 December 2020

G protein-coupled receptor deorphanizations

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12 December 2020

G-protein coupled receptor 120 is involved in glucose metabolism in fat cells

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12 December 2020

Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets

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12 December 2020

Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1.

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12 December 2020

International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands

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12 December 2020

Identification of G-protein-coupled receptor 120 as a tumor-promoting receptor that induces angiogenesis and migration in human colorectal carcinoma

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12 December 2020

The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism

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12 December 2020

Cyclooxygenase-2 induction in macrophages is modulated by docosahexaenoic acid via interactions with free fatty acid receptor 4 (FFA4).

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12 December 2020

The therapeutic potential of GPR120: a patent review

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12 December 2020

G protein-coupled receptor 120 signaling regulates ghrelin secretion in vivo and in vitro

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12 December 2020

GPR120 on Kupffer cells mediates hepatoprotective effects of ω3-fatty acids

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12 December 2020

Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells

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12 December 2020

Mechanisms of homologous and heterologous phosphorylation of FFA receptor 4 (GPR120): GRK6 and PKC mediate phosphorylation of Thr³⁴⁷, Ser³⁵⁰, and Ser³⁵⁷ in the C-terminal tail

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12 December 2020

Role of docosahexaenoic acid treatment in improving liver histology in pediatric nonalcoholic fatty liver disease

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12 December 2020

Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion

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12 December 2020

GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans

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12 December 2020

The fish oil ingredient, docosahexaenoic acid, activates cytosolic phospholipase A₂ via GPR120 receptor to produce prostaglandin E₂ and plays an anti-inflammatory role in macrophages.

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12 December 2020

Activation of the omega-3 fatty acid receptor GPR120 mediates anti-inflammatory actions in immortalized hypothalamic neurons

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12 December 2020

Alteration of the glucagon axis in GPR120 (FFAR4) knockout mice: a role for GPR120 in glucagon secretion

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12 December 2020

Exposure to omega-3 fatty acids at early age accelerate bone growth and improve bone quality

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12 December 2020

Concomitant action of structural elements and receptor phosphorylation determines arrestin-3 interaction with the free fatty acid receptor FFA4

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12 December 2020

The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120).

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12 December 2020

Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).

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12 December 2020

Omega-3 free fatty acids suppress macrophage inflammasome activation by inhibiting NF-κB activation and enhancing autophagy

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12 December 2020

A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice

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12 December 2020

CD36, but not GPR120, is required for efficient fatty acid utilization during endurance exercise

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12 December 2020

Expression of the long-chain fatty acid receptor GPR120 in the gonadotropes of the mouse anterior pituitary gland.

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12 December 2020

Mining microarray datasets in nutrition: expression of the GPR120 (n-3 fatty acid receptor/sensor) gene is down-regulated in human adipocytes by macrophage secretions.

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12 December 2020

Novel Association Between a Nonsynonymous Variant (R270H) of the G-Protein–Coupled Receptor 120 and Liver Injury in Children and Adolescents With Obesity

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12 December 2020

Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects.

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12 December 2020

Role of GPR120 in cell motile activity induced by 12-O-tetradecanoylphorbol-13-acetate in liver epithelial WB-F344 cells.

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12 December 2020

Tumor necrosis factor α decreases glucagon-like peptide-2 expression by up-regulating G-protein-coupled receptor 120 in Crohn disease

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12 December 2020

Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion.

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12 December 2020

Eicosapentaenoic acid upregulates VEGF-A through both GPR120 and PPARγ mediated pathways in 3T3-L1 adipocytes.

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12 December 2020

High fat feeding affects the number of GPR120 cells and enteroendocrine cells in the mouse stomach

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12 December 2020

Omega-3 fatty acids induce Ca(2+) mobilization responses in human colon epithelial cell lines endogenously expressing FFA4.

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12 December 2020

Understanding the pathophysiological mechanisms in the pediatric non-alcoholic fatty liver disease: The role of genetics

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12 December 2020

Endogenous Ligand for GPR120, Docosahexaenoic Acid, Exerts Benign Metabolic Effects on the Skeletal Muscles via AMP-activated Protein Kinase Pathway

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12 December 2020

Transcriptional and Functional Characterization of the G Protein-Coupled Receptor Repertoire of Gastric Somatostatin Cells.

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12 December 2020

Fish oil and flax seed oil supplemented diets increase FFAR4 expression in the rat colon

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12 December 2020

Diets Containing α-Linolenic (ω3) or Oleic (ω9) Fatty Acids Rescues Obese Mice From Insulin Resistance

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12 December 2020

G Protein-Coupled Receptor 120 Signaling Negatively Regulates Osteoclast Differentiation, Survival, and Function

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12 December 2020

FFA4/GPR120 agonists: a survey of the recent patent literature

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12 December 2020

A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1

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12 December 2020

10.1016/J.BCP.2016.01.021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6415295&resulttype=core&format=json

13 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6415295&resulttype=core&format=json

13 May 2020

1 reference