Concise Review: Heteroplasmic Mitochondrial DNA Mutations and Mitochondrial Diseases: Toward iPSC-Based Disease Modeling, Drug Discovery, and Regenerative Therapeutics (Q38724510)

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scientific article published on 6 February 2016

Language	Label	Description	Also known as
English	Concise Review: Heteroplasmic Mitochondrial DNA Mutations and Mitochondrial Diseases: Toward iPSC-Based Disease Modeling, Drug Discovery, and Regenerative Therapeutics	scientific article published on 6 February 2016

Statements

scholarly article

1 reference

Europe PubMed Central

5 September 2017

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Europe PubMed Central

Concise Review: Heteroplasmic Mitochondrial DNA Mutations and Mitochondrial Diseases: Toward iPSC-Based Disease Modeling, Drug Discovery, and Regenerative Therapeutics (English)

1 reference

Europe PubMed Central

5 September 2017

mitochondrial DNA

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based on heuristic

inferred from title

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based on heuristic

inferred from title

author name string

Hideyuki Hatakeyama

1

1 reference

Europe PubMed Central

5 September 2017

Yu-Ichi Goto

2

1 reference

Europe PubMed Central

5 September 2017

publication date

6 February 2016

1 reference

Europe PubMed Central

5 September 2017

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Europe PubMed Central

5 September 2017

34

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Europe PubMed Central

5 September 2017

801-808

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Europe PubMed Central

5 September 2017

4

1 reference

Europe PubMed Central

5 September 2017

Mitochondrial DNA mutations in human disease

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Human mitochondrial DNA: roles of inherited and somatic mutations

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Mutations causing mitochondrial disease: What is new and what challenges remain?

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Human mitochondrial tRNAs: biogenesis, function, structural aspects, and diseases

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

MtDNA mutation in MERRF syndrome causes defective aminoacylation of tRNA(Lys) and premature translation termination

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

A disease-associated G5703A mutation in human mitochondrial DNA causes a conformational change and a marked decrease in steady-state levels of mitochondrial tRNA(Asn).

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Mitochondrial DNA and RNA processing in MELAS.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Specific correlation between the wobble modification deficiency in mutant tRNAs and the clinical features of a human mitochondrial disease

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Effects of dichloroacetate in three patients with MELAS.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

L-arginine improves the symptoms of strokelike episodes in MELAS.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Endothelial dysfunction in MELAS improved by l-arginine supplementation.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Mitochondrial rejuvenation after induced pluripotency

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https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Energy metabolism in human pluripotent stem cells and their differentiated counterparts

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Metabolic plasticity in stem cell homeostasis and differentiation

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Mitochondrial DNA haplotypes define gene expression patterns in pluripotent and differentiating embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Mitochondrial respiratory dysfunction caused by a heteroplasmic mitochondrial DNA mutation blocks cellular reprogramming.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Induced pluripotent stem cells generated from diabetic patients with mitochondrial DNA A3243G mutation

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Induced pluripotent stem cells with a mitochondrial DNA deletion

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Disease-causing mitochondrial heteroplasmy segregated within induced pluripotent stem cell clones derived from a patient with MELAS.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Tissue- and cell-type-specific manifestations of heteroplasmic mtDNA 3243A>G mutation in human induced pluripotent stem cell-derived disease model.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Impaired respiratory function in MELAS-induced pluripotent stem cells with high heteroplasmy levels.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Molecular pathomechanisms and cell-type-specific disease phenotypes of MELAS caused by mutant mitochondrial tRNA(Trp).

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Metabolic rescue in pluripotent cells from patients with mtDNA disease

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Mitochondrial diabetes mellitus: prevalence and clinical characterization of diabetes due to mitochondrial tRNA(Leu(UUR)) gene mutation in Japanese patients.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

A new syndrome of refractory sideroblastic anemia with vacuolization of marrow precursors and exocrine pancreatic dysfunction

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

MITOCHONDRIAL DNA DELETION IN PEARSON'S MARROW/PANCREAS SYNDROME

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

A Balbiani body and the fusome mediate mitochondrial inheritance during Drosophila oogenesis.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Pathogenic mitochondrial tRNA point mutations: nine novel mutations affirm their importance as a cause of mitochondrial disease

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Human embryonic stem cells derived by somatic cell nuclear transfer.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick Type C patient-specific iPS cells.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Synaptic dysregulation in a human iPS cell model of mental disorders

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

New Protocol to Optimize iPS Cells for Genome Analysis of Fibrodysplasia Ossificans Progressiva.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Deficits in human trisomy 21 iPSCs and neurons

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Brief report: isogenic induced pluripotent stem cell lines from an adult with mosaic down syndrome model accelerated neuronal ageing and neurodegeneration

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Transmission of mitochondrial DNA diseases and ways to prevent them.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Concise reviews: Assisted reproductive technologies to prevent transmission of mitochondrial DNA disease

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Paternal inheritance of mitochondrial DNA

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Maternal inheritance of mitochondrial DNA by diverse mechanisms to eliminate paternal mitochondrial DNA

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Autophagy is essential for preimplantation development of mouse embryos.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

The role of autophagy during the oocyte-to-embryo transition.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

New evidence confirms that the mitochondrial bottleneck is generated without reduction of mitochondrial DNA content in early primordial germ cells of mice

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Evidence from human oocytes for a genetic bottleneck in an mtDNA disease

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Random genetic drift determines the level of mutant mtDNA in human primary oocytes

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Offspring from Oocytes Derived from in Vitro Primordial Germ Cell-like Cells in Mice

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Generation of eggs from mouse embryonic stem cells and induced pluripotent stem cells.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Induction of mouse germ-cell fate by transcription factors in vitro.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

A mesodermal factor, T, specifies mouse germ cell fate by directly activating germline determinants

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

SOX17 is a critical specifier of human primordial germ cell fate

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Human primordial germ cell commitment in vitro associates with a unique PRDM14 expression profile.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Towards germline gene therapy of inherited mitochondrial diseases

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Polar body genome transfer for preventing the transmission of inherited mitochondrial diseases.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Regulators weigh benefits of 'three-parent' fertilization.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Medicine. Mitochondrial replacement, evolution, and the clinic.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Potential impact of human mitochondrial replacement on global policy regarding germline gene modification.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Mitochondrial donation--how many women could benefit?

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Selective elimination of mitochondrial mutations in the germline by genome editing

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.2292

21 January 2018

Identifiers

10.1002/STEM.2292

1 reference

Europe PubMed Central

5 September 2017

1 reference

Europe PubMed Central

5 September 2017

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