The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14. (Q38780596)

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31 March 2020

title

The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14 (English)

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31 March 2020

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Ji-Man Park

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Chang Hwa Jung

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describes a project that uses

31 March 2020

ImageJ

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11 June 2022

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based on heuristic

inferred from PubMed Central ID database lookup

cites work

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ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase.

6 September 2017

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FIP200 regulates targeting of Atg16L1 to the isolation membrane

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Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy

6 September 2017

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6 September 2017

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Atg9 vesicles are an important membrane source during early steps of autophagosome formation

6 September 2017

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SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling

6 September 2017

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Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy.

6 September 2017

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Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation

6 September 2017

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Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy.

6 September 2017

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Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy

6 September 2017

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Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

6 September 2017

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

6 September 2017

1 reference

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Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

6 September 2017

1 reference

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The association of AMPK with ULK1 regulates autophagy

6 September 2017

1 reference

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An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis

6 September 2017

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Autophagy in mammalian development and differentiation

6 September 2017

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Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L.

6 September 2017

1 reference

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Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

6 September 2017

1 reference

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Negative regulation of Vps34 by Cdk mediated phosphorylation

6 September 2017

1 reference

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6 September 2017

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Atg101, a novel mammalian autophagy protein interacting with Atg13

6 September 2017

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A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy

6 September 2017

1 reference

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Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

6 September 2017

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Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex

6 September 2017

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ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

6 September 2017

1 reference

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ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

6 September 2017

1 reference

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An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation

6 September 2017

1 reference

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Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

6 September 2017

1 reference

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Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase

6 September 2017

1 reference

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Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835982

Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835982

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835982

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835982

Autophagy in the Pathogenesis of Disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835982

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835982

Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835982

A statistical model for identifying proteins by tandem mass spectrometry

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835982

Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835982

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835982

Tor-mediated induction of autophagy via an Apg1 protein kinase complex

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835982

GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835982

Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835982

Signal transduction pathways in macroautophagy.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835982

Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835982

Glucose-starved cells do not engage in prosurvival autophagy

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835982

Glucose induces autophagy under starvation conditions by a p38 MAPK-dependent pathway.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835982

Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835982

Dynamic association of the ULK1 complex with omegasomes during autophagy induction.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835982

PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835982

10.1080/15548627.2016.1140293

31 August 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27046250%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27046250%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

PubMed publication ID

27046250

1 reference