Specific roles for the PI3K and the MEK-ERK pathway in IGF-1-stimulated chemotaxis, VEGF secretion and proliferation of multiple myeloma cells: study in the 5T33MM model. (Q38797390)

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scientific article published on March 2004

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English	Specific roles for the PI3K and the MEK-ERK pathway in IGF-1-stimulated chemotaxis, VEGF secretion and proliferation of multiple myeloma cells: study in the 5T33MM model.	scientific article published on March 2004

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scholarly article

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24 November 2019

Specific roles for the PI3K and the MEK-ERK pathway in IGF-1-stimulated chemotaxis, VEGF secretion and proliferation of multiple myeloma cells: study in the 5T33MM model (English)

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24 November 2019

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multiple myeloma

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1

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24 November 2019

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K Asosingh

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24 November 2019

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R Kooijman

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24 November 2019

E Van Valckenborgh

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24 November 2019

M Bakkus

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24 November 2019

B Van Camp

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24 November 2019

K Vanderkerken

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24 November 2019

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1 March 2004

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24 November 2019

British Journal of Cancer

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24 November 2019

90

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24 November 2019

5

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24 November 2019

1076-1083

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24 November 2019

The F-actin content of multiple myeloma cells as a measure of their migration.

1 reference

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6 September 2017

PI 3-kinases and PTEN: how opposites chemoattract

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6 September 2017

The 5TMM series: a useful in vivo mouse model of human multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409634

6 September 2017

Roles of PI3Ks in leukocyte chemotaxis and phagocytosis

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6 September 2017

Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass

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6 September 2017

Murine 5T multiple myeloma cells induce angiogenesis in vitro and in vivo

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Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases

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The somatomedin hypothesis: 2001.

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6 September 2017

Selective initial in vivo homing pattern of 5T2 multiple myeloma cells in the C57BL/KalwRij mouse

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Phosphorylation and regulation of Raf by Akt (protein kinase B)

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6 September 2017

Organ involvement and phenotypic adhesion profile of 5T2 and 5T33 myeloma cells in the C57BL/KaLwRij mouse

1 reference

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6 September 2017

Lymphocyte homing and homeostasis

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6 September 2017

Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation

1 reference

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6 September 2017

Primary tumor cells of myeloma patients induce interleukin-6 secretion in long-term bone marrow cultures

1 reference

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6 September 2017

Insulin-like growth factors and their binding proteins: biological actions

1 reference

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6 September 2017

Bone marrow angiogenesis and progression in multiple myeloma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409634

6 September 2017

Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis

1 reference

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6 September 2017

Secretion of insulinlike growth factor I and insulinlike growth factor-binding proteins by murine bone marrow stromal cells

1 reference

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6 September 2017

Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor

1 reference

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14 September 2017

Prolonged nuclear retention of activated extracellular signal-regulated kinase 1/2 is required for hepatocyte growth factor-induced cell motility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409634

25 September 2017

The SDF-1-CXCR4 axis stimulates VEGF secretion and activates integrins but does not affect proliferation and survival in lymphohematopoietic cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409634

25 September 2017

Role of phosphoinositide 3-kinase in monocyte recruitment under flow conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409634

25 September 2017

Insulin-like growth factor induces the survival and proliferation of myeloma cells through an interleukin-6-independent transduction pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409634

25 September 2017

In vivo induction of insulin-like growth factor-I receptor and CD44v6 confers homing and adhesion to murine multiple myeloma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409634

25 September 2017

The involvement of adhesion molecules in the biology of multiple myeloma

1 reference

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25 September 2017

Idiopathic paraproteinemia. II. Transplantation of the paraprotein-producing clone from old to young C57BL/KaLwRij mice

1 reference

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25 September 2017

'Role of bone marrow stromal cells in the growth of human multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409634

25 September 2017

Insulin-like growth factor I is a growth and survival factor in human multiple myeloma cell lines.

1 reference

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25 September 2017

MIP-1alpha induces activation of phosphatidylinositol-3 kinase that associates with Pyk-2 and is necessary for B-cell migration

1 reference

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22 June 2018

Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409634

22 June 2018

Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409634

22 June 2018

Functional insulin and insulin-like growth factor-1 receptors are preferentially expressed in multiple myeloma cell lines as compared to B-lymphoblastoid cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409634

22 June 2018

Insulinlike growth factor-I signaling in multiple myeloma: downstream elements, functional correlates, and pathway cross-talk

1 reference

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31 August 2018

Different effects of glucose starvation on expression and stability of VEGF mRNA isoforms in murine ovarian cancer cells.

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31 August 2018

Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin- and phosphatidylinositol 3-kinase-dependent PKC alpha activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409634

31 August 2018

Hepatocyte growth factor/scatter factor stimulates migration of rat mammary fibroblasts through both mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt pathways.

1 reference

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31 August 2018

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1 reference

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1 reference

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor-1 acts as a chemoattractant factor for 5T2 multiple myeloma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/14997210

12 December 2020

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inferred from PubMed ID database lookup

Insulin-like growth factor I-triggered cell migration and invasion are mediated by matrix metalloproteinase-9

1 reference

https://pubmed.ncbi.nlm.nih.gov/14997210

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TGF-beta1 enhances SDF-1alpha-induced chemotaxis and homing of naive T cells by up-regulating CXCR4 expression and downstream cytoskeletal effector molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/14997210

12 December 2020

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inferred from PubMed ID database lookup

United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition)

1 reference

https://pubmed.ncbi.nlm.nih.gov/14997210

12 December 2020

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IGF-I stimulates chemotaxis of human neuroblasts. Involvement of type 1 IGF receptor, IGF binding proteins, phosphatidylinositol-3 kinase pathway and plasmin system

1 reference

https://pubmed.ncbi.nlm.nih.gov/14997210

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/14997210

12 December 2020

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inferred from PubMed ID database lookup

Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation

1 reference

https://pubmed.ncbi.nlm.nih.gov/14997210

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1038/SJ.BJC.6601613

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24 November 2019

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24 November 2019

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24 November 2019

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