Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. (Q38810349)

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3 March 2020

title

Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents (English)

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3 March 2020

8

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Katherine A. Hoadley

6

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3 March 2020

author name string

Pu Wang

1

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3 March 2020

Jing Wu

2

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3 March 2020

Shenghong Ma

3

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3 March 2020

Lei Zhang

4

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3 March 2020

Jun Yao

5

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3 March 2020

Matthew D Wilkerson

7

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Kun-Liang Guan

9

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3 March 2020

Dan Ye

10

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3 March 2020

Yue Xiong

11

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publication date

10 December 2015

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3 March 2020

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3 March 2020

volume

13

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issue

11

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page(s)

2353-2361

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D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth

3 March 2020

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IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

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DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation

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IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

9 September 2017

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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

9 September 2017

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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

9 September 2017

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Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

9 September 2017

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Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA

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22 June 2018

Identifiers

DOI

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