Cation-selective transporters are critical to the AMPK-mediated antiproliferative effects of metformin in human breast cancer cells. (Q38811683)

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2 March 2020

title

Cation-selective transporters are critical to the AMPK-mediated antiproliferative effects of metformin in human breast cancer cells (English)

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2 March 2020

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4

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2 March 2020

author name string

Hao Cai

1

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2 March 2020

Yunhui Zhang

2

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2 March 2020

Tianxiang Kevin Han

3

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2 March 2020

Dhiren R Thakker

5

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2 March 2020

language of work or name

English

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publication date

8 January 2016

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International Journal of Cancer

2 March 2020

published in

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volume

138

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2 March 2020

issue

9

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2 March 2020

page(s)

2281-2292

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Diabetes and cancer: is diabetes causally related to cancer?

2 March 2020

cites work

1 reference

Diabetes increases the risk of breast cancer: a meta-analysis

21 January 2018

1 reference

Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types

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Metformin enhances the antiproliferative and apoptotic effect of bicalutamide in prostate cancer.

21 January 2018

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The antidiabetic drug metformin inhibits gastric cancer cell proliferation in vitro and in vivo

21 January 2018

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Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK.

21 January 2018

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Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro

21 January 2018

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Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial.

21 January 2018

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Long-term metformin use is associated with decreased risk of breast cancer.

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Effect of metformin on survival outcomes in diabetic patients with triple receptor-negative breast cancer

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Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer

21 January 2018

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Mortality after incident cancer in people with and without type 2 diabetes: impact of metformin on survival

21 January 2018

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Mitogenic properties of insulin and insulin analogues mediated by the insulin receptor

21 January 2018

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Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells

21 January 2018

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Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells

21 January 2018

1 reference

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

21 January 2018

1 reference

Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase-Dependent Regulation of the Orphan Nuclear Receptor SHP

21 January 2018

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Metformin increases insulin sensitivity and basal glucose clearance in Type 2 (non-insulin dependent) diabetes mellitus

21 January 2018

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Obligatory role of membrane events in the regulatory effect of metformin on the respiratory chain function

21 January 2018

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Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines.

21 January 2018

1 reference

Metformin transport by a newly cloned proton-stimulated organic cation transporter (plasma membrane monoamine transporter) expressed in human intestine

21 January 2018

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Four cation-selective transporters contribute to apical uptake and accumulation of metformin in Caco-2 cell monolayers

21 January 2018

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Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver

21 January 2018

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Drug transport proteins in the liver

21 January 2018

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cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2.

21 January 2018

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Hormone receptor status, tumor characteristics, and prognosis: a prospective cohort of breast cancer patients

21 January 2018

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Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype

21 January 2018

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Triple-negative breast cancer: distinguishing between basal and nonbasal subtypes

21 January 2018

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The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy.

21 January 2018

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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

21 January 2018

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Metformin induces both caspase-dependent and poly(ADP-ribose) polymerase-dependent cell death in breast cancer cells

21 January 2018

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Mechanisms underlying saturable intestinal absorption of metformin

21 January 2018

1 reference

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

21 January 2018

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Differential expression of organic cation transporter OCT-3 in oral premalignant and malignant lesions: potential implications in the antineoplastic effects of metformin

21 January 2018

1 reference

Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics

21 January 2018

1 reference

Relevance of the OCT1 transporter to the antineoplastic effect of biguanides

21 January 2018

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21 January 2018

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The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin.

21 January 2018

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Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin.

21 January 2018

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Antihyperglycaemic efficacy, response prediction and dose-response relations of treatment with metformin and sulphonylurea, alone and in primary combination.

21 January 2018

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Therapeutic comparison of metformin and sulfonylurea, alone and in various combinations. A double-blind controlled study.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/IJC.29965

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2 March 2020

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