Cynomolgus Monkey as a Clinically Relevant Model to Study Transport Involving Renal Organic Cation Transporters: In Vitro and In Vivo Evaluation. (Q38816622)

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scientific article published on 25 November 2015

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English	Cynomolgus Monkey as a Clinically Relevant Model to Study Transport Involving Renal Organic Cation Transporters: In Vitro and In Vivo Evaluation.	scientific article published on 25 November 2015

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1 March 2020

Cynomolgus Monkey as a Clinically Relevant Model to Study Transport Involving Renal Organic Cation Transporters: In Vitro and In Vivo Evaluation (English)

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Hong Shen

1

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Tongtong Liu

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Hao Jiang

3

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Craig Titsch

4

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Kristin Taylor

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Hamza Kandoussi

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Xi Qiu

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Cliff Chen

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Sunil Sukrutharaj

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Kathy Kuit

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Gabe Mintier

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Prasad Krishnamurthy

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R Marcus Fancher

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Jianing Zeng

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A David Rodrigues

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Punit Marathe

16

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publication date

25 November 2015

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Drug Metabolism and Disposition

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2

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238-249

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1 March 2020

Tissue distribution and ontogeny of organic cation transporters in mice

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Effects of tetraalkylammonium compounds with different affinities for organic cation transporters on the pharmacokinetics of metformin

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Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1.

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Double-transfected MDCK cells expressing human OCT1/MATE1 or OCT2/MATE1: determinants of uptake and transcellular translocation of organic cations.

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Molecular mechanism of renal tubular secretion of the antimalarial drug chloroquine

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Drug specificity and intestinal membrane localization of human organic cation transporters (OCT).

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Involvement of carnitine/organic cation transporter OCTN1/SLC22A4 in gastrointestinal absorption of metformin.

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Molecular mechanisms of organic cation transport in OCT2-expressing Xenopus oocytes

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A human transporter protein that mediates the final excretion step for toxic organic cations

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21 January 2018

Cynomolgus monkey as a potential model to assess drug interactions involving hepatic organic anion transporting polypeptides: in vitro, in vivo, and in vitro-to-in vivo extrapolation

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A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters

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