Activation of DNA Damage Response Pathways during Lytic Replication of KSHV. (Q38865828)

7 September 2017

Activation of DNA Damage Response Pathways during Lytic Replication of KSHV. (English)

1 reference

7 September 2017

0 references

George L Skalka

2

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Grant S Stewart

object named as

Grant S Stewart

3

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David J. Blackbourn

object named as

David J Blackbourn

5

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Robert Hollingworth

1

object named as

Robert Hollingworth

1 reference

7 September 2017

Andrew D Hislop

4

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PMC publication ID

4488719

7 September 2017

Roger J Grand

6

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7 September 2017

5 June 2015

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7 September 2017

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7 September 2017

7

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7 September 2017

6

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7 September 2017

2908-2927

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Creative Commons Attribution 4.0 International

7 September 2017

start time

5 June 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Kaposi's sarcoma-associated herpesvirus induces the ATM and H2AX DNA damage response early during de novo infection of primary endothelial cells, which play roles in latency establishment

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Conserved herpesvirus kinases target the DNA damage response pathway and TIP60 histone acetyltransferase to promote virus replication.

9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

9 September 2017

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9 September 2017

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A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus

9 September 2017

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Antiviral activity and mechanism of action of ganciclovir

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Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage

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Functional interaction between Epstein-Barr virus replication protein Zta and host DNA damage response protein 53BP1.

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Human cytomegalovirus disrupts both ataxia telangiectasia mutated protein (ATM)- and ATM-Rad3-related kinase-mediated DNA damage responses during lytic infection

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Use of the red fluorescent protein as a marker of Kaposi's sarcoma-associated herpesvirus lytic gene expression

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Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis.

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Cell cycle regulation by Kaposi's sarcoma-associated herpesvirus K-bZIP: direct interaction with cyclin-CDK2 and induction of G1 growth arrest.

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Human cytomegalovirus inhibits cellular DNA synthesis and arrests productively infected cells in late G1.

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1 reference

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1 reference

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Identifiers

DOI

10.3390/V7062752

1 reference

7 September 2017

1 reference

PMC publication ID

4488719

7 September 2017

PubMed publication ID

26057167

1 reference

PMC publication ID

4488719