A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer (Q38867604)

7 September 2017

title

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer (English)

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7 September 2017

9

Zora Modrusan

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7 September 2017

Jeffrey Eastham-Anderson

7

object named as

Jeffrey Eastham Anderson

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7 September 2017

author name string

Felipe de Sousa e Melo

1

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7 September 2017

Antonina V Kurtova

2

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7 September 2017

Jonathan M Harnoss

3

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7 September 2017

Noelyn Kljavin

4

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7 September 2017

Joerg D Hoeck

5

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7 September 2017

Jeffrey Hung

6

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7 September 2017

Elaine E Storm

8

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7 September 2017

Hartmut Koeppen

10

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7 September 2017

Gerrit J P Dijkgraaf

11

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7 September 2017

Robert Piskol

12

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7 September 2017

Frederic J de Sauvage

13

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7 September 2017

language of work or name

English

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publication date

1 March 2017

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7 September 2017

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7 September 2017

volume

543

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7 September 2017

issue

7647

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7 September 2017

page(s)

676-680

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Colorectal cancer statistics, 2014.

7 September 2017

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Crypt stem cells as the cells-of-origin of intestinal cancer

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Targeting LGR5+ cells with an antibody-drug conjugate for the treatment of colon cancer

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Monoclonal antibodies against Lgr5 identify human colorectal cancer stem cells

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7 January 2021

Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas

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The developing cancer stem-cell model: clinical challenges and opportunities

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Prospective identification of tumorigenic breast cancer cells

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Identification of human brain tumour initiating cells

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A restricted cell population propagates glioblastoma growth after chemotherapy

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SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma.

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Lymph node-independent liver metastasis in a model of metastatic colorectal cancer

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A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

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In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.

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Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids.

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Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients

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Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis

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The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers

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Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells

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Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

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Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging.

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7 January 2021

Krt19(+)/Lgr5(-) Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine

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7 January 2021

Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters

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7 January 2021

Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function.

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7 January 2021

Regulation and plasticity of intestinal stem cells during homeostasis and regeneration

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7 January 2021

Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration

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7 January 2021

Targeting metastasis-initiating cells through the fatty acid receptor CD36

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Identifiers

DOI

10.1038/NATURE21713

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Dimensions Publication ID

7 September 2017

1084128603

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