p38 Mitogen activated protein kinase (MAPK): a new therapeutic target for reducing the risk of adverse pregnancy outcomes (Q38908783)

24 December 2017

review article

1 reference

title

p38 Mitogen activated protein kinase (MAPK): a new therapeutic target for reducing the risk of adverse pregnancy outcomes (English)

1 reference

24 December 2017

author name string

Ramkumar Menon

series ordinal

1

1 reference

24 December 2017

John Papaconstantinou

series ordinal

2

1 reference

24 December 2017

language of work or name

English

0 references

publication date

26 July 2016

1 reference

24 December 2017

Expert Opinion on Therapeutic Targets

published in

1 reference

24 December 2017

volume

20

1 reference

24 December 2017

page(s)

1397-1412

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24 December 2017

issue

12

1 reference

24 December 2017

Placental membrane aging and HMGB1 signaling associated with human parturition

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Oxidative stress damage as a detrimental factor in preterm birth pathology

17 June 2018

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Design and synthesis of 5-[(2-chloro-6-fluorophenyl)acetylamino]-3-(4-fluorophenyl)-4-(4-pyrimidinyl)isoxazole (AKP-001), a novel inhibitor of p38 MAP kinase with reduced side effects based on the antedrug concept

17 June 2018

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Calcium channel blockers for inhibiting preterm labour and birth

17 June 2018

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Senescence of primary amniotic cells via oxidative DNA damage

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Preterm birth-associated neurodevelopmental impairment estimates at regional and global levels for 2010.

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Surfactant protein (SP)-A suppresses preterm delivery and inflammation via TLR2

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17 June 2018

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17 June 2018

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Endothelial MKK3 is a critical mediator of lethal murine endotoxemia and acute lung injury

17 June 2018

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PPAR-γ -- a possible drug target for complicated pregnancies

17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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KR-003048, a potent, orally active inhibitor of p38 mitogen-activated protein kinase

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Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804

17 June 2018

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Should we be prescribing repeated courses of antenatal corticosteroids?

17 June 2018

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Increased p38-MAPK is responsible for chemotherapy resistance in human gastric cancer cells

17 June 2018

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The diagnosis, management, and postnatal prevention of intraventricular hemorrhage in the preterm neonate

17 June 2018

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Spontaneous preterm birth, a clinical dilemma: etiologic, pathophysiologic and genetic heterogeneities and racial disparity

17 June 2018

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17 June 2018

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The fetal inflammatory response syndrome

17 June 2018

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Infection and the role of inflammation in preterm premature rupture of the membranes

17 June 2018

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Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation

17 June 2018

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Effect of experimental genital mycoplasmosis on production of matrix metalloproteinases in membranes and amniotic fluid of Sprague-Dawley rats

17 June 2018

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The preterm parturition syndrome.

17 June 2018

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The role of inflammation and infection in preterm birth

17 June 2018

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Inter- and intracellular signaling in amyotrophic lateral sclerosis: role of p38 mitogen-activated protein kinase

17 June 2018

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Human carboxylesterase isozymes: catalytic properties and rational drug design

17 June 2018

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Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice

17 June 2018

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MAPK signalling pathways as molecular targets for anti-inflammatory therapy--from molecular mechanisms to therapeutic benefits

17 June 2018

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Antedrugs: an approach to safer drugs

17 June 2018

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Cyclo-oxygenase (COX) inhibitors for treating preterm labour

17 June 2018

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Ink4a/Arf expression is a biomarker of aging

17 June 2018

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Fetal membrane inflammatory cytokines: a switching mechanism between the preterm premature rupture of the membranes and preterm labor pathways

17 June 2018

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The role of matrix degrading enzymes and apoptosis in rupture of membranes

17 June 2018

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Oxidative stress in the placenta

17 June 2018

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Involvement of the INK4a/Arf gene locus in senescence

17 June 2018

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Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway

17 June 2018

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Prodrug and antedrug: two diametrical approaches in designing safer drugs

17 June 2018

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Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Apoptosis signal-regulating kinase 1 (ASK1) induces neuronal differentiation and survival of PC12 cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Selective plasma hydrolysis of glucocorticoid gamma-lactones and cyclic carbonates by the enzyme paraoxonase: an ideal plasma inactivation mechanism

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Therapeutic strategies for allergic diseases

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Descriptive epidemiology of asthma.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Preterm labor and preterm premature rupture of the membranes. Diagnosis and management

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Recent advances in elucidating the pathogenesis of preterm delivery, the detection of patients at risk, and preventative therapies

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

The fetal inflammatory response syndrome.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

High bisphenol A (BPA) concentration in the maternal, but not fetal, compartment increases the risk of spontaneous preterm delivery

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Environmental Pollutant Polybrominated Diphenyl Ether, a Flame Retardant, Induces Primary Amnion Cell Senescence

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Analysis of the disposition of a novel p38 MAPK inhibitor, AKP-001, and its metabolites in rats with a simple physiologically based pharmacokinetic model.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Histological evidence of oxidative stress and premature senescence in preterm premature rupture of the human fetal membranes recapitulated in vitro.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Association between preterm birth and intrauterine growth retardation and child asthma

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Increased oxidative stress in human fetal membranes overlying the cervix from term non-labouring and post labour deliveries.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

p38 MAPK inhibitors attenuate pro-inflammatory cytokine production and the invasiveness of human U251 glioblastoma cells.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Cigarette smoke induces oxidative stress and apoptosis in normal term fetal membranes.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Diversity in cytokine response to bacteria associated with preterm birth by fetal membranes.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

The adaptor protein MyD88 is essential for E coli-induced preterm delivery in mice

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Antibiotics for spontaneous preterm birth

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Oxidative stress early in pregnancy and pregnancy outcome

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J(2) delays lipopolysaccharide-induced preterm delivery and reduces mortality in the newborn mouse

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Efficient adult skeletal muscle regeneration in mice deficient in p38beta, p38gamma and p38delta MAP kinases

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Patterns of cytokine profiles differ with pregnancy outcome and ethnicity.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Histone deacetylase inhibitors exert time-dependent effects on nuclear factor-kappaB but consistently suppress the expression of proinflammatory genes in human myometrial cells

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Long-term but not short-term p38 mitogen-activated protein kinase inhibition improves cardiac function and reduces cardiac remodeling post-myocardial infarction

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Synthesis and biological evaluation of 1,2,4-triazinylphenylalkylthiazolecarboxylic acid esters as cytokine-inhibiting antedrugs with strong bronchodilating effects in an animal model of asthma

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-kappa B and I kappa B kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Single-dose pharmacokinetics and pharmacodynamics of RWJ 67657, a specific p38 mitogen-activated protein kinase inhibitor: a first-in-human study.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

N-Acetyl-cysteine inhibits phospholipid metabolism, proinflammatory cytokine release, protease activity, and nuclear factor-kappaB deoxyribonucleic acid-binding activity in human fetal membranes in vitro.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Protective effect of N-acetylcysteine against fetal death and preterm labor induced by maternal inflammation

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

The effect of aging on p38 signaling pathway activity in the mouse liver and in response to ROS generated by 3-nitropropionic acid

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Neurologic and developmental disability after extremely preterm birth. EPICure Study Group.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

The mammalian carboxylesterases: from molecules to functions.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5182513

Synthesis and pharmacology of anti-inflammatory steroidal antedrugs

22 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1080%2F14728222.2016.1216980

p38MAPK Controls Expression of Multiple Cell Cycle Inhibitors and Islet Proliferation with Advancing Age

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1080%2F14728222.2016.1216980

Oral p38 mitogen-activated protein kinase inhibition with BIRB 796 for active Crohn's disease: a randomized, double-blind, placebo-controlled trial

21 January 2018

1 reference

12 December 2020

Effect of corticosteroids for fetal maturation on perinatal outcomes. NIH Consensus Development Panel on the Effect of Corticosteroids for Fetal Maturation on Perinatal Outcomes

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12 December 2020

Plasma levels of thrombin-antithrombin complexes predict preterm premature rupture of the fetal membranes

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12 December 2020

Nutritional and antimicrobial interventions to prevent preterm birth: an overview of randomized controlled trials

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12 December 2020

Expression of inflammatory cytokines (interleukin-1 beta and interleukin-6) in amniochorionic membranes

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12 December 2020

Interleukin-10 inhibition of interleukin-6 in human amniochorionic membrane: transcriptional regulation

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12 December 2020

Glucocorticoid specific binding: structure-activity relationships

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Placental lesions caused by experimental infection of Sprague-Dawley rats with Mycoplasma pulmonis

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12 December 2020

Interleukin-10 and transforming growth factor-beta inhibit amniochorion tumor necrosis factor-alpha production by contrasting mechanisms of action: therapeutic implications in prematurity

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The effect of transforming growth factor and interleukin-10 on interleukin-8 release by human amniochorion may regulate histologic chorioamnionitis

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10.1080/14728222.2016.1216980

Identifiers

DOI

1 reference

24 December 2017

PMCID

5182513

1 reference

24 December 2017

PubMed ID

27459026

1 reference

24 December 2017