DNA damage-induced S and G2/M cell cycle arrest requires mTORC2-dependent regulation of Chk1. (Q38933652)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25460505%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

title

DNA damage-induced S and G2/M cell cycle arrest requires mTORC2-dependent regulation of Chk1 (English)

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24 February 2020

0 references

3

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24 February 2020

author name string

Jogitha Selvarajah

series ordinal

1

1 reference

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24 February 2020

Androulla Elia

series ordinal

2

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24 February 2020

Abdeladim Moumen

series ordinal

4

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24 February 2020

language of work or name

English

0 references

publication date

1 January 2015

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24 February 2020

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24 February 2020

volume

6

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24 February 2020

issue

1

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24 February 2020

page(s)

427-440

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Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathways

24 February 2020

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Regulation of FANCD2 by the mTOR pathway contributes to the resistance of cancer cells to DNA double-strand breaks

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9 September 2017

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Inhibition of mTOR kinase by AZD8055 can antagonize chemotherapy-induced cell death through autophagy induction and down-regulation of p62/sequestosome 1

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Feedback control of p53 translation by REDD1 and mTORC1 limits the p53-dependent DNA damage response

9 September 2017

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A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation

9 September 2017

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mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion

9 September 2017

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Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress

9 September 2017

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S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response

9 September 2017

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The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress

9 September 2017

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Regulation of protein synthesis by ionizing radiation.

9 September 2017

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ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress

9 September 2017

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

9 September 2017

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Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

9 September 2017

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p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

9 September 2017

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Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial

9 September 2017

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Regulation of the cellular DNA double-strand break response

9 September 2017

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Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?

9 September 2017

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Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit

9 September 2017

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The coordinate regulation of the p53 and mTOR pathways in cells

9 September 2017

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

9 September 2017

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DNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint

9 September 2017

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9 September 2017

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

9 September 2017

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mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

9 September 2017

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

9 September 2017

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Human immunodeficiency virus 1 envelope glycoprotein complex-induced apoptosis involves mammalian target of rapamycin/FKBP12-rapamycin-associated protein-mediated p53 phosphorylation

9 September 2017

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ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

9 September 2017

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Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

9 September 2017

1 reference

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Activation of p70 ribosomal protein S6 kinase is an essential step in the DNA damage-dependent signaling pathway responsible for the ultraviolet B-mediated increase in interstitial collagenase (MMP-1) and stromelysin-1 (MMP-3) protein levels in huma

9 September 2017

1 reference

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381605

Mechanism of activation of protein kinase B by insulin and IGF-1

9 September 2017

1 reference

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DNA damage-induced CHK1 autophosphorylation at Ser296 is regulated by an intramolecular mechanism

9 September 2017

1 reference

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Targeting of mTORC2 prevents cell migration and promotes apoptosis in breast cancer.

9 September 2017

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Oncogenic EGFR signaling activates an mTORC2-NF-κB pathway that promotes chemotherapy resistance

9 September 2017

1 reference

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Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381605

Chk1 instability is coupled to mitotic cell death of p53-deficient cells in response to virus-induced DNA damage signaling

14 September 2017

1 reference

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Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway

14 September 2017

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Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.

14 September 2017

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Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity.

14 September 2017

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Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53.

14 September 2017

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Antisense inhibition of Chk2/hCds1 expression attenuates DNA damage-induced S and G2 checkpoints and enhances apoptotic activity in HEK-293 cells

25 September 2017

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mTOR regulates DNA damage response through NF-κB-mediated FANCD2 pathway in hematopoietic cells

25 September 2017

1 reference

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The PCPH oncoprotein antagonizes the proapoptotic role of the mammalian target of rapamycin in the response of normal fibroblasts to ionizing radiation

17 June 2018

1 reference

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TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks.

17 June 2018

1 reference

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CRL4(CDT2) targets CHK1 for PCNA-independent destruction

21 August 2018

1 reference

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Targeting the Akt/mammalian target of rapamycin pathway for radiosensitization of breast cancer.

21 August 2018

1 reference

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Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer

21 August 2018

1 reference

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The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.

21 August 2018

1 reference

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21 August 2018

Identifiers

DOI

10.18632/ONCOTARGET.2813

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25460505%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25460505%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

PubMed publication ID

25460505

1 reference